140 results about "Cell sensitivity" patented technology

An implantable biosensor assembly and system includes an enzymatic sensor probe from which subcutaneous and interstitial glucose levels may be inferred. The assembly may be associated by direct percutaneous connection with electronics, such as for signal amplification, sensor polarization, and data download, manipulation, display, and storage. The biosensor comprises a miniature probe characterized by lateral flexibility and tensile strength and has large electrode surface area for increased sensitivity. Irritation of tissues surrounding the probe is minimized due to ease of flexibility and small cross section of the sensor. Foreign body reaction is diminished due to a microscopically rough porous probe surface.

A capacitive proximity switch for detecting the change in the capacitance relative to a setpoint capacitance by the approach or retreat of an object in the sensitive area of a proximity switch, especially for use in the door handle of a motor vehicle, provides reliable error detection and error suppression at a fundamentally high sensitivity of the capacitive proximity switch by utilizing an evaluation unit that evaluates a measured value of the change in capacitance over time and depending on the time behavior of the measured value activates changes the operating threshold from a first threshold (which can be caused by a false object coming into or out of the sensitive area of the proximity switch) to a higher second threshold which can be reached only at a relatively greater change in capacitance caused by a target object coming into or out of the sensitive area of the proximity switch.

A powered dispenser for dispensing individual sheet segments from a continuous roll of sheet material provided with spaced tear lines comprises a powered feed mechanism, a releasable, powered drive mechanism, a powered transfer mechanism, a pair of web sensing sensors, a capacitive sensing system providing automatic sensitivity adjustment, and control circuitry. A dual power supply system provides a mechanical lock-out functionality, and the control system is protected from electrostatic build-up on the surface of the feed roller. The web sensor, and an antenna plate of the capacitive sensing system, are provided on respective printed circuit boards mounted in overlying relation. Utilizing signals received from the pair of web sensors and the capacitive sensing system, the control circuitry senses the presence of a user to activate the powered drive mechanism, and prevents further dispensing of the sheet material until a previously dispensed segment is separated from the roll. The web sensors detection of a leading edge of the sheet material initiates a predetermined interval of sheet material advancement providing a proper placement of successive tear lines. Various approaches may be utilized to accommodate inadvertent sheet “tabbing” scenarios. The web sensors, together with the control circuitry, are also used to detect the depletion, or absence, of a working roll of sheet material, whereupon the control circuitry controls the powered transfer mechanism to automatically transfer the web feed supply from a depleted working roll to a reserve roll. The powered transfer mechanism may include a motor driven transfer bar, or provide motor driven release of a spring biased transfer bar. Another arrangement allows for ready release of a roll core, and drop of the same into an open dispenser cover for removal.

The invention provides devices that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient detection of individual microscopic targets at low magnification for highly sensitive testing. The invention does not require washing steps and thus allows sensitive and specific detection while simplifying manual operation and lowering costs and complexity in automated operation. In short, the invention provides devices that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests.

A sensor for monitoring the lambda of a component of a reactant feed stream flowing through a fuel cell stack. The sensor comprises one or more fuel cells that are sensitive to a change in lambda of a specific component of a reactant feed stream flowing through the fuel cell. The sensitivity of the fuel cell causes a voltage produced by the lambda sensing fuel cell to vary in response to variation in the lambda of the specific component. The variation of the voltage output can be modeled and / or compared to empirical data to correlate the voltage output to the lambda of the specific component. Based on the lambda of the specific component, the operation of the fuel cell stack can be optimized.

The present invention provides a method for detecting and differentiating disease states with high sensitivity and specificity. The method allows for a determination of whether a cell-based sample contains abnormal cells and, for certain diseases, is capable of determining the histologic type of disease present. The method detects changes in the level and pattern of expression of the molecular markers in the cell-based sample. Panel selection and validation procedures are also provided.

The invention discloses a MOS-pipe-based double-grid-regulation ultra-high-sensitivity biosensor, which is suitable for a series of early-stage tumour detection. The sensor is made from an SOI sheet,and a unique double-grid control structure is formed through ion implantation. The sensor is made via ultraviolet lithography combined with an NLD etching method and can detect a trace amount of a tumour marker immediately without labeling. Compared with a common sensor used for detecting current or conductance, the sensor can detect change of capacitance in a channel in an antigen-antibody combination process. A detection method related in the invention is stable and good in interference immunity, and can meet the requirements of detection range and sensitivity, has extremely outstanding performance particularly with respect to detection sensitivity, and can detect a sample with the lowest concentration in a range of 1 fg / ml-1 ng / ml.

The present invention relates provides methods of predicting cell sensitivity to a test agent. In some embodiments, the cells are cultured in a culture medium having serum.

The present invention relates to a Y-type nucleotide probe having two probe portions on a single body such that it can be widely used for genotype testing and analysis with improved sensitivity, specificity, and accuracy, as well as to a DNA microarray, kit, and gene analysis method using the y-probe. The Y-probe of the invention is configured with five portions, comprising: a left probe portion, a left stem portion, a linker, a right stem portion, and a right probe portion. The DNA microarray of the present invention may have improved testing accuracy as it can perform a simultaneously overlapping test on the same gene or a simultaneous test on two different target genes. In particular, by simultaneously testing a target gene and a control gene in one spot, analysis errors can be reduced, quantitative analysis is made possible, and standardization is facilitated. The Y-probe of the present invention can be used for genotype analysis and gene expression analysis, as well as for mutation and SNP analysis, and can thus be broadly used for the diagnosis and prognosis of diseases and for genetic diagnosis for determining a course of treatment, etc.