4-methylpyrazole formulations for inhibiting ethanol intolerance
a technology of ethanol intolerance and formulation, applied in the direction of antinoxious agents, drug compositions, biocides, etc., can solve the problems of ineffective treatment of another the dose of 4-mp found to be helpful in treating one genetic subpopulation of alcohol intolerance persons may not be equally helpful, and the effect of reducing the likelihood or risk of a subj
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[0062]Provided herein are methods, compositions and formulations useful for reducing or ameliorating the severity of, or preventing, an adverse physiological symptom associated with acetaldehyde accumulation accompanying ethanol consumption in a subject with reduced or absent aldehyde dehydrogenase subtype 2 activity. The subject may express specific polymorphisms of the aldehyde dehydrogenase subtype 2 (ALDH2) gene and the alcohol dehydrogenase subtype 2 (ADH2) gene. For example, the subject may be a carrier of the variant ALDH2*2 allele of the ALDH2 gene, and may further be a carrier of the variant ADH2*2 allele of the ADH2 gene, as described herein.
[0063]As explained below, the methods provided comprise the administration of 4-MP or a physiologically acceptable salt of 4-MP. Without intending to be bound by any particular theory or mechanism, it is believed that 4-MP acts to inhibit alcohol dehydrogenase (ADH) to reduce the accumulation of acetaldehyde production that results fro...
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