92results about How to "Reduce perfusion" patented technology

A system including an implantable neurostimulator device capable of modulating cerebral blood flow to treat epilepsy and other neurological disorders. In one embodiment, the system is capable of modulating cerebral blood flow (also referred to as cerebral perfusion) in response to measurements and other observed conditions. Perfusion may be increased or decreased by systems and methods according to the invention as clinically required.

A method of providing hypothermia to a patient including the steps of inserting a fluid delivery member into a peritoneal cavity of the patient; delivering hypothermia fluid from a fluid source into the peritoneal cavity through the delivery member; and limiting fluid pressure within the peritoneal cavity without providing feedback control to the fluid source. The invention also provides an apparatus for practicing the method.

Methods for pharyngeal and cerebral cooling by delivering an ice slurry, slush or super-cooled gel to a patient's nasal cavity, oral cavity and / or throat are described. In one method, a cooling assembly is inserted into a nasal cavity through a patient's nostril. The cooling assembly includes a flexible balloon defining a chamber and a first elongate tubular member having a lumen in fluid communication with the chamber. A ice slurry having a temperature between about −5° C. and about 5° C. is delivered through the lumen of the first elongate tubular member into the chamber, wherein the flexible balloon expands to place it in contact with the nasal cavity. In another method, an expandable member is inserted through the patient's oral cavity and positioned such that when expanded it forms a low pressure seal substantially isolating the nasal and oral cavities from the patient's trachea. An ice slurry is delivered directly to the patient's nasal cavity.

A method for providing and adjusting cerebral cooling in response to changes in a physiological parameter. A spray having a boiling point between 38-300° C. is delivered to the surface of a patient's nasal cavities. The spray causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis. A physiological parameter, such as cerebral temperature, changes in cerebral blood flow or brain oxygenation is monitored. The delivery rate of the spray is adjusted in response to the physiological parameter.

A cerebral cooling device that uses a pressurized source to deliver a fluid that evaporates in the nasal cavity to provide cooling and has a balloon on the distal end that inflates from some of the pressure from the pressurized source. The device includes a nasal catheter having delivery ports located in the distal region and a balloon on the distal end. The proximal end of the catheter is in fluid communication with a pressurized source of a low boiling point fluid. A manifold located between the pressurized source and the catheter distributes the fluid and pressure from the pressurized source to a first lumen of the catheter to inflate the balloon and to a second lumen of the catheter through the delivery ports to cool the nasal cavity. A check valve in the manifold ensures that the fluid and pressure are first delivered to the balloon.

Methods are provided for partial aortic obstruction for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially obstruct aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter and a distally mounted expandable member. The expandable member may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide therapeutic intervention.

A method to visualize, display, analyze and quantify angiography, perfusion, and the change in angiography and perfusion in real time, is provided. This method captures image data sequences from indocyanine green near infra-red fluorescence imaging used in a variety of surgical procedure applications, where angiography and perfusion are critical for intraoperative decisions.

The invention provides a color optical filter and a manufacturing method thereof. The color optical filter comprises a first photoresistance unit and a second photoresistance unit, wherein the first photoresistance unit and the second photoresistance unit constitute a pixel layer; and the manufacturing method comprises the following steps: forming the photoresistance unit and then forming a colorresistance convex block for controlling a gap between an array baseplate and a color film baseplate while manufacturing the second photoresistance unit. By adopting the manufacturing method, the manufacturing process can be reduced and the manufacturing cost of a liquid crystal display can be effectively reduced.

Methods for cerebral and systemic cooling via a patient's nasopharyngeal cavity are described. In one method, a cooling assembly is inserted into a nasal cavity through a patient's nostril. A substantially dry gas is delivered through a lumen of the catheter onto the surface of the patient's nasal cavity. Evaporative heat loss cools the patient's nasal cavity. If additional cooling is needed, a liquid coolant is delivered through a separated lumen of the catheter. The liquid coolant is nebulized at a plurality of delivery ports on the distal end of the catheter and is delivered onto the surface of the patient's nasal cavity in combination with the dry gas. The dry gas enhances evaporation of the nebulized coolant and additional cooling is provided from the evaporative heat loss of the liquid coolant.

A method for stimulating perfusion and minimizing postischemic reperfusion injury. A patient is selected having compromised perfusion in a tissue or in the microcirculation of an organ. An ultrasound transducer is applied to a location near the tissue. The transducer is activated to initiate exposure of the tissue to ultrasound at a frequency of 100 KHz to 2.5 MHz for 0.5 to 15 minutes duration, wherein local vasodilatation is stimulated. In certain cases, the methods further include a step of confirming that local vasodilatation is stimulated by measuring enhancement in perfusion. Ultrasound devices are also described for carrying out the methods. The devices and methods can be used to enhance myocardial perfusion, cerebral perfusion, and perfusion of transplanted tissues.

The invention relates to the combined administration of a PDE4 inhibitor and a PDE5 inhibitor for the treatment of a disease in which phosphodiesterase 4 (PDE4) and / or phosphodiesterase 5 (PDE5) is detrimental.

A cerebral cooling device that uses a pressurized source to deliver a fluid that evaporates in the nasal cavity to provide cooling and has a balloon on the distal end that inflates from some of the pressure from the pressurized source. The device includes a nasal catheter having delivery ports located in the distal region and a balloon on the distal end. The proximal end of the catheter is in fluid communication with a pressurized source of a low boiling point fluid. A manifold located between the pressurized source and the catheter distributes the fluid and pressure from the pressurized source to a first lumen of the catheter to inflate the balloon and to a second lumen of the catheter through the delivery ports to cool the nasal cavity. A check valve in the manifold ensures that the fluid and pressure are first delivered to the balloon.

The invention discloses a double-cylinder rotating compressor which comprises a shell body, a motor, an upper flange, an upper air cylinder, a crank shaft, an upper running pulley, a partition plate, a lower running pulley, a lower air cylinder and a lower flange. The radius of a cylinder matched segment of the portion in which the crank shaft is matched with an inner hole of the partition plate is larger than biggest eccentric radiuses of an upper eccentric portion and a lower eccentric portion of the crank shaft, the cylinder matched segment of the crank shaft is matched with the inner hole of the partition plate in a sliding mode to form an auxiliary bearing of the compressor, the bottom end face of the lower eccentric portion of the crank shaft is arranged in an alignment mode corresponding to the bottom end face of the lower air cylinder, and the corresponding lower flange is a plane plate. The lower flange enables the lower running pulley and the lower eccentric portion of the crank shaft to be blocked in the lower air cylinder in an alignment mode, an original short shaft of the crank shaft is removed, the height of the shell body is reduced, frozen oil filling injection amount is reduced, and power consumption of the compressor is reduced. The invention further discloses an eccentric assembling method of the double-cylinder rotating compressor, a combined centering assembling mode from top to bottom is adopted by the method, and the problem that coaxiality difference of the long shaft and the short shaft of the existing crank brings problem for a gap of the lower cylinder is solved.

The invention relates to a process for the production of IL-18 binding protein (IL-18BP), and to a composition comprising IL-18BP characterized by a specific glycosylation pattern.

Ischemia is treated to prevent or manage disease by delivering stem cells derived from cord blood and / or tissue. A patient suffering from disease caused in at least some part by ischemia is selected. At least one dose consisting of an effective amount of stem cells is administrated through intravenous (IV), intra thecal, intra-arterial, via catheter into the organ, via Myostar catheter into the heart, intracoronary, intrapericardial, and / or by direct injection into the organ. Effectiveness of the administration is monitored at selected time periods to determine whether there exists an improved clinical indication. A second dose is administered by a method that is at least invasive as that utilized in the prior dose, and the steps are repeated until the clinical indication shows improvement or until there is contraindication to continued treatment. Diseases include at least one of Ischemia, arteriosclerosis, complications of ischemia, decreased perfusion, aging or diabetes.

The invention provides a heat pump air conditioner and a control method thereof. The heat pump air conditioner comprises a refrigerant circulation loop and an indoor heat exchanger (27); the refrigerant circulation loop consists of a compressor (23), an intermediate condenser (24), an intermediate evaporator (26) and a throttling device (25); the indoor heat exchanger (27) capable of achieving refrigeration or heating in a room can exchange heat with the intermediate evaporator (26) or the intermediate condenser (24) through a water circulation loop in which water flows. The heat pump air conditioner can effectively prevent refrigerant leakage caused by the connection of a refrigerant pipeline into the room and effectively avoid harm caused to people in vehicles or indoors, and the use safety and reliability of the heat pump air conditioner are improved. As the water circulation loop is adopted for heat exchange with air, valve parts, including electromagnetic valves, reversing valvesand the like which are resistant to high pressure, high temperature and corrosion are effectively reduced, the development cost is greatly reduced, the fault probability is effectively decreased, andrunning is safer and more reliable.

The invention provides a transition pipe for refrigeration equipment. The transition pipe comprises an inlet section, a first silencer, a middle section and a second silencer, wherein a capillary pipe is inserted into the transition pipe via the first end of the inlet section; the first end of the first silencer is connected with the second end of the inlet section; the first silencer is used for attenuating the eruption sound generated when the capillary pipe carries out eruption; the first end of the middle section is connected with the second end of the first silencer; the first end of the second silencer is connected with the second end of the middle section; the second silencer is used for attenuating the eruption sound generated when the capillary pipe carries out eruption, which is transmitted by the middle section; and the transition pipe is integrally formed by the inlet section, the first silencer, the middle section and the second silencer. The transition pipe has the following advantages: the eruption sound generated when the capillary pipe carries out eruption can be effectively attenuated, thus being beneficial to reducing the whole noise value of the refrigeration equipment; vortex generated by turbulent flow formed on the walls of the jet pipe of the capillary pipe is avoided, thus reducing vibration of the walls of the refrigerant exciting pipe and reducing flow pulsation; and the production cost is low. The invention also provides the refrigeration equipment.

A method and a corresponding system for assessing a haemodynamic parameter for a vascular region of interest of a patient based on angiographic images are provided. After acquiring multiple angiographic images, a three dimensional (3D) representation of at least a first portion of the respective region of interest is performed, and geometric features are extracted from complete or partial views. Additional geometric features are extracted from partial incomplete views. A complete set of 3D geometric features for an anatomical structure, such as a vessel tree, is then generated by combining the extracted geometric features and estimating any missing geometric features. Using the complete set of 3D geometric features, a feature-based assessment of the haemodynamic parameter, such as a fractional flow reserve, is then performed.

Methods are provided for partial aortic occlusion for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. The descending aorta is accessed. A device is then located downstream from the takeoff of the brachiocephalic artery. The device is operated to at least partially obstruct blood flow in the aorta during systole and diastole. A physiologic parameter can be measured. The device can then be adjusted to modify the degree of obstruction based on the measured physiologic parameter.

The invention relates to a process for the production of IL-18 binding protein (IL-18BP), and to a composition comprising IL-18BP characterized by a specific glycosylation pattern.

The present invention provides methods for cellular seeding onto three-dimensional fibroblast constructs, three-dimensional fibroblast constructs seeded with muscle cells, and uses therefore.

A method for cerebral and systemic cooling by circulating a cold liquid through a nasal catheter looped through the patient's nasal cavities and around the nasal septum. The nasal catheter is inserted into the patient's first nostril, advanced through the nasal cavity, around the nasal septum and out of the patient's second nostril. A cold fluid having a temperature between about −20° C. and about 37° C. is flowed though a lumen in the nasal catheter to cool the nasal cavity. The nasal catheter may have one or more flexible balloons mounted on the catheter such that when the catheter is looped around the nasal septum, the balloon(s) are positioned in a portion of the patient's first and second nasal cavities. When a cold liquid is circulated through the catheter lumen, the flexible balloons expand to a contact the inner walls of the nasal cavities and provide direct cooling of the nasal cavities.

The invention discloses low-density hard polyurethane foam which is prepared by respectively premixing components A and components B, jointly mixing and foaming. The components A include, by weight, 100 parts of composite polyol, 5-15 parts of cyclopentane, 1.5-6 parts of amine catalyst, 1-5 parts of silicon surfactant and 0.8-2.5 parts of water, and the components B include, by weight, 1-10 partsof butane and 120-220 parts of isocyanate, wherein each raw material above is based on 100 parts of composite polyol. The preparation method includes following steps: (1), preparing the components A;(2), preparing the components B; (3), injecting the components A and the components B into a closed mold, allowing sufficient reaction, and demolding to obtain the hard polyurethane foam. The low-density hard polyurethane foam is environment-friendly and excellent in performance.

The invention relates to the novel use of guanylate cyclase activators for the treatment of partial and global respiratory failure.

The invention provides a heat-pump water heater and an adjusting method thereof. The heat-pump water heater comprises a main loop, a liquid storage device, a first branch, a second branch and a third branch. The main loop comprises a compressor, a first heat exchanger, a throttling device, a second heat exchanger and a gas-liquid separator, and the compressor, the first heat exchanger, the throttling device, the second heat exchanger and the gas-liquid separator are connected sequentially in series. The liquid storage device is connected to a first pipeline section through the first branch, the first pipeline section is located between an exhaust outlet of the compressor and the first heat exchanger, and a pressure increasing valve is arranged on the first branch. The liquid storage is connected to a second pipeline section through the second branch, the second pipeline section is located between an inlet of the gas-liquid separator and the second heat exchanger, and a pressure reducing valve is arranged on the second branch. The liquid storage device is connected to a third pipeline section through the third branch, and a flow regulating valve is arranged on the third branch. By means of the eat-pump water heater and the adjusting method thereof, the problem that a heat-pump water heater cannot effectively adjust the refrigerant amount in a system when the operating condition of the system changes in the prior art is solved.