The invention relates to a method for synthesizing a
meropenem intermediate, which comprises the following steps: (1) in an
inert gas
atmosphere, adding an
organic solvent, a compound II, a
noble metal catalyst and auxiliary catalysts into a reactor, heating the materials to perform a reaction, and monitoring the reaction by TLC or HPLC; (2) at the end of the reaction, adding the
organic solvent, cooling the reaction solution, adding an organic alkali or DPC, and monitoring a reaction by the TLC or HPLC; (3) at the end of the reaction, cooling the reaction solution, adding the organic alkali and a compound III, performing a reaction at a controlled temperature, and monitoring the reaction by the TLC or HPLC; and (4) washing, removing a water phase, dehydrating an organic phase, filtering to remove
solid, concentrating the organic phase, adding the
organic solvent for
crystallization, filtering the solution, washing the crystals, and
drying the crystals to obtain the target compound I. Compared with the techniques of the same kind, the method, which is simple and convenient in operation, of the invention has the advantages of adding two auxiliary catalysts at the same time, greatly reducing the consumption of
noble metal catalyst, making raw materials react more completely, producing less impurities and improving product yield.