44results about How to "Not intended to limit the scope of protection" patented technology

The invention discloses a preparation method of 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid. The preparation method includes the following steps of subjecting 3-hydroxyl -4-halogenated benzaldehyde represented as formula (2) to alkylation to obtain a compound represented as formula (3); subjecting the compound represented as the formula (3) to hydroxylation to obtain a compound represented as formula (4); subjecting the compound represented as the formula (4) to alkylation to obtain a compound represented as formula (5); and subjecting the compound represented as the formula (5) to oxidation to obtain the 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid (1). According to the preparation method, the preparation method is easy and convenient to operate, reaction yield of each step is high, intermediates are easy to purify, reported defects of preparation methods of the 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid serving as the key intermediate of roflumilast are overcome, great progressive effects and practical application value are achieved, and besides, the preparation method is mostly beneficial for industrial production. The reaction general formula is shown as follows.

A portable magnetic resonance system includes a permanent magnet, a nuclear magnetic resonance probe, and control electronics. The control electronics are configured to transmit to the probe a magnetic resonance excitation signal having an excitation frequency f, receive from the probe a magnetic resonance measurement signal, detect in the magnetic resonance measurement signal a magnetic resonance frequency f0, and automatically adjust the excitation frequency f until the difference between the excitation frequency and the magnetic resonance frequency is approximately equal to a target offset.

The invention discloses a method for preparing 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid. The method comprises the following steps of: performing alkylation on 3-hydroxy-4-halogenated benzoate shown as a formula (2) to obtain a compound of a formula (3); performing hydroxylation on the compound of the formula (3) to obtain a compound of a formula (4); performing esterification on the compound of the formula (4) to obtain a compound of a formula (5); performing alkylation on the compound of the formula (5) to obtain a compound of a formula (6); and hydrolyzing the compound of the formula (6), and thus obtaining the 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid (1). The method is easy and convenient to operate, the reaction yield in each step is high, and intermediates are easy to purify. The method overcomes the defects of the reported method for preparing Roflumilast key intermediate 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid, and has great positive progress effects and practical application value. Moreover, the invention has the greatest advantage that the method is suitable for industrialized production. The reaction general formula is shown in the specification.

The invention relates to a method for sensing the closing time of an injector by using an artificial neural network and a control method of a fuel injector by using the method. A method for sensing a closing time of an injector using an artificial neural network may include: sensing, by a controller, a voltage generated by an injector; performing, by the controller, a preprocess to derive an input matrix using variation characteristics of the voltage; and performing, by the controller, a closing time prediction to derive a closing time of the injector by an artificial neural network model including an input layer including the input matrix, a hidden layer, and an output layer.

A side-by-side type side beam structure for an electric vehicle includes: a side beam inner portion located on a side surface of a center floor, where the center floor forms an underbody, a side beam outer portion, and a plurality of side-by-side members; the side beam outer part is coupled to the side beam inner part and is configured to form a side beam inner space; a plurality of side-by-side members are provided in the side sill interior space in a longitudinal direction of the vehicle.

The invention discloses a gear inspection device and a gear inspection method using the gear inspection device. The gear inspection device includes: a measuring unit, which has a detection rod, and the detection rod is installed so as to be rotatably mounted on a bracket relative to the The working gear can move forward and backward, and the size of the rotating working gear is measured by the measuring ball provided at the top end of the probe rod; the driving unit is installed on the bracket so as to be connected to the a measuring unit, and moves the probe rod forward and backward; and a controller, which receives a displacement measurement value related to the position of the detection rod measured by the measurement unit, and converts the displacement measurement value into numeric value.

The invention provides a vehicle shift control device and a method thereof. Specifically, the shift control device includes: a transmission including a first clutch and a second clutch; a torque source for generating power for driving a vehicle; a data detector for detecting a state of the vehicle data; and a vehicle controller for connecting the current gear synchronizer to the next gear drive gear, releasing the first clutch connected to the current gear drive gear if the vehicle state data satisfies the shift condition , performing speed control of the torque source while maintaining the second clutch connected to the driving gear of the next gear in a slipping state, and if the vehicle state data satisfies the speed control completion condition, releasing the second clutch and connecting the first clutch, to complete the shift to the target gear.

A system for determining the transfer of driving control authority for an autonomous vehicle is disclosed. The system includes a risk calculation device, a determination reference calculation device, and a determination device, the risk calculation device recognizing the driver's line of sight to calculate the risk when transferring the driving control authority of the autonomous driving vehicle, the determination reference calculation device calculating the determination reference to Whether it is possible to transfer the driving control authority of the accelerator pedal, the deceleration pedal and the steering wheel of the automatic driving vehicle is determined based on the calculated risk, and the determining means determines whether to transfer the driving control authority of the automatic driving vehicle based on the calculated determination reference.

The present disclosure relates to a method for controlling the clutch of a vehicle with an automated manual transmission and a technique for improving durability of the clutch and shifting stability.The present disclosure provides a method of controlling a clutch of an automated manual transmission (AMT) vehicle, which reduces a micro-slip control time in order to improve durability of the clutchby performing a full-lock control of the clutch after slip control for learning a clutch characteristic curve. Additionally, the method shortens time to open the clutch for a subsequent shifting by predicting the time when a shift restarts after the full-lock control and by resuming the micro-slip control.

A rear structure for a vehicle includes a rear floor and a pair of inclined members joined to a lower surface of the rear floor and configured to be symmetrical to each other with respect to a longitudinal center line of the rear floor, each of a pair of tilt members extends from a first side and a second side of the rear floor, respectively, to a rear portion of the rear floor.

The present application provides a vehicle body transmission system using a transmission unit. The system may include: a base configured to move along a base rail, a moving unit including a supporting member configured to support a vehicle body; wherein the moving unit is configured to move the supporting member in a predetermined direction , and the mobile unit is arranged on the base; a tool unit is arranged outside the base track and is selectively coupled to the mobile unit, wherein the tool unit is configured to provide a driving torque, Thus, the moving unit controls the position of the supporting member.

A rear side vehicle body structure of a vehicle includes: a side sill outer panel forming a lower portion of a side surface of a vehicle body, extending in a front-rear longitudinal direction of the vehicle, and including a bonding surface portion on a rear end portion, a rear side wall inner panel, and a first reinforcing member; the rear side wall inner plate is connected to the side beam outer plate and forms a vehicle body rear side face located on the rear portion of a rear vehicle door. And a first reinforcing member joined to the side sill outer panel and the rear side wall inner panel and configured to cover a joining portion between the side sill outer panel and the rear side wall inner panel, in which the joining surface portion protrudes rearward and is joined to a surface of the rear side wall inner panel.

The present application relates to a method for controlling a clutch of a vehicle having an automatic manual transmission, which relates to a technique for improving durability and shift stability of the clutch. The present invention provides a method for controlling a clutch of an automatic manual transmission (AMT) vehicle, which learns the characteristic curve of the clutch by performing a full lock control of the clutch after slip control, thereby reducing the minute slip control time, thereby improving the durability of the clutch. Furthermore, this method can shorten the clutch-on time for the subsequent shift by predicting the time when the shift is started again after the full lock control, and by restarting the micro-slip control.

The invention discloses a method for preparing 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid. The method comprises the following steps of: performing alkylation on 3-hydroxy-4-halogenated benzoate shown as a formula (2) to obtain a compound of a formula (3); performing hydroxylation on the compound of the formula (3) to obtain a compound of a formula (4); performing esterification on the compound of the formula (4) to obtain a compound of a formula (5); performing alkylation on the compound of the formula (5) to obtain a compound of a formula (6); and hydrolyzing the compound of the formula (6), and thus obtaining the 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid (1). The method is easy and convenient to operate, the reaction yield in each step is high, and intermediates are easy to purify. The method overcomes the defects of the reported method for preparing Roflumilast key intermediate 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid, and has great positive progress effects and practical application value. Moreover, the invention has the greatest advantage that the method is suitable for industrialized production. The reaction general formula is shown in the specification.

An anti-virus active compound 9 -[2 - (phosphine carboxylmethoxy) ethyl] bicyclic alcohol ester is manufactured by: reacting 9 - [ 2- (phosphine carboxylmethoxy) ethyl ] adenosine purine with 4, 4'- dimethyl-5, 6, 5' 6'- bis(methylenedioxy) - 2 - hydroxymethyl - 2' - methoxycarbonyl biphenyl. This bicyclic alcohol ester could exist as its salt and are a kind white solid. Experiment shows that the compounds have the characteristics of high melting point, low hygroscopicity, photo-stability and thermal-stability, obvious anti-virus effect, protect and well care liver. It's a preferred pharmaceutical for anti-hepatitis virus.