The invention discloses a thermal conductive polyurethane synthetic leather production method which comprises the following process: selecting base cloth, coating with wet process polyurethane slurry, solidifying, washing with water, expanding and drying, veneering by dry method, and finishing the surface; first of all, the base cloth is coated with the wet process polyurethane slurry with conductive filler; then, the coated substrate is solidified by wet method for adjusting of bubble hole structure and expanding and drying for production of thermal conductive and breathable Base; finally thermal conductive breathable polyurethane synthetic leather is produced by veneering by dry method and finishing the surface of the thermal conductive and breathable Base. The thermal conductive polyurethane synthetic leather prepared by the method is relatively high in thermal conductivity coefficient, the thermal conductivity coefficient reaches 0.06-0.09W .M <-1> .K <-1>, compared with traditional synthetic leather, the thermal conductivity is increased by more than 30%, and the bubble hole is even, delicate, soft in hand feeling, good in drapability, air and moisture permeability, similar to natural leather in apparent and hand feeling, and simple in manufacturing process.