The invention belongs to the technical field of welding materials, and particularly relates to a 550 MPa-grade flux-cored wire with excellent moisture resistance. The flux-cored wire comprises a carbon steel sheath and a flux core. The flux core comprises the following components in percentage by mass: 34-42% of rutile, 2-6% of electrolytic manganese, 10-15% of silicon-manganese alloy, 14-18% of nickel powder, 2-6% of ferrotitanium, 1-5% of aluminum-magnesium alloy, 1-3% of sodium fluoride, 1-4% of zircon sand, 4-8% of ferroboron, 1-3% of potassium titanate, 2-6% of silicon iron, 1-6% of magnesium powder, 2-5% of feldspar, 1-5% of fluorinated ethylene propylene and the balance iron powder. According to the 550 MPa-grade flux-cored wire with the excellent moisture resistance, pure CO2 serves as shielding gas, the 550 MPa-grade flux-cored wire can be used in a maritime work construction working environment, the impact toughness requirement at -40 DEG C is met, the diffusible hydrogen content is lower than 5 ml / 100 g, the yield strength grade of the flux-cored wire is 460 MPa grade, the tensile strength grade reaches 550 MPa grade, and the flux-cored wire is good in cold crack resistance, extremely high in moisture absorption resistance and high in pore resistance.