The invention discloses a guide device, a
landmark layout method and a guide method based on multi-view vision and inertial navigation, belonging to the
automatic control field. The guide device comprises oblique-downward cameras, a vertical-downward camera, an
inertial measurement unit, a barrier sensor, a
radio frequency card reader and a guide controller, wherein the oblique-downward cameras are arranged on two sides of a vehicle body, the vertical-downward camera is arranged at the center of the vehicle body, the
inertial measurement unit is arranged on the top of the vehicle body, the barrier sensor is arranged on the front side of the vehicle body, the
radio frequency card reader is arranged at the bottom of the vehicle body, and the guide controller is electrically connected with the cameras, the
inertial measurement unit, the barrier sensor and the
radio frequency card reader. Color guiding marked lines are distributed on two sides of an operation path of an automatic guide vehicle (AGV), and radio frequency tags and
colored positioning marks which are in positional coincident with each other are distributed on the guiding marked lines. A guide method of the AGV comprises the steps of carrying out region traffic navigation in a middle region between the guiding marked lines on two sides, and carrying out
path tracking guide along with the guiding marked lines on one side. The guide method has cross-regional remote motion flexibility and intra-regional target positioning accuracy.