The invention belongs to the technical field of rubber materials, and particularly relates to a self-adhesive antibacterial silicone rubber patch and a preparation method thereof, and the self-adhesive antibacterial silicone rubber patch comprises the following components by weight: 100 parts of antibacterial silicone rubber, 20-60 parts of a reinforcing agent, 3-8 parts of a structure control agent, 1-3 parts of a vulcanizing agent, 1-3 parts of a flame retardant, and 1-3 parts of an antioxidant. All the components of the composition have a good synergistic effect; the prepared silicone rubber patch has the advantages of wide spectrum, high antibacterial property, good biocompatibility, low toxicity, good weather resistance, excellent mechanical properties, good self-adhesion and good storage stability; in addition, the preparation method is simple, the raw materials are easy to obtain, the energy is saved, the environment is protected, the reproducibility is good, and the productionefficiency is high.