Antibacterial agent and preparation method thereof

A technology of antibacterial agent and monoglyceride, applied in the field of antibacterial agent and its preparation, can solve the problems of skin itching, redness, congestion, etc., and achieve the effect of high-efficiency broad-spectrum antibacterial property and wide application range

Inactive Publication Date: 2013-10-30
BYD CO LTD
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention solves the existing technical problem that dimethyl fumarate easily causes allergic reactions such as skin itching, redness, and congestion, and provides an antibacterial agent that is not easy to cause allergic reactions such as skin itching, redness, and congestion, and a preparation method thereof

Method used

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  • Antibacterial agent and preparation method thereof
  • Antibacterial agent and preparation method thereof
  • Antibacterial agent and preparation method thereof

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preparation example Construction

[0021] The present invention also provides a kind of preparation method of antibacterial agent of the present invention, and this method comprises the following steps:

[0022] Preparation of S1, fumaric acid monoester acid chloride

[0023] Add fumaric acid monoester, thionyl chloride and glass beads in the reaction vessel, heat the reaction until the fumaric acid monoester is completely dissolved, and the solution is transparent; continue to keep the temperature at reflux for 30-90min, and finish the reaction to obtain fumaric acid monoester acyl chloride; Concrete reaction equation is as follows:

[0024] .

[0025] S2, the preparation of antibacterial agent

[0026] Add monoglyceride and pyridine into the reaction vessel, stir to dissolve; heat to 100-110°C, then slowly add fumaric acid monomethyl chloride to it, and continue to react for 10-60min to obtain the antibacterial agent of the present invention; the specific reaction is as follows :

[0027] .

[0028] ...

Embodiment 1

[0039] 1, the preparation of fumaric acid monoester

[0040] Add maleic anhydride and methanol in a molar ratio of 1:1 in the reaction vessel, keep the temperature at 40°C for 60 minutes, then add the catalyst anhydrous aluminum chloride AlCl -3-- (The addition amount is 6% of the raw material), stir evenly, raise the temperature to 80°C and continue the reaction for 60 minutes to obtain the corresponding white granular fumaric acid monoester.

[0041] 2, the preparation of fumaric acid monoester acid chloride

[0042] In the reaction vessel, add fumaric acid monoester and thionyl chloride SOCl at a molar ratio of 0.9:1 -2 and 3 glass beads, install a reflux device and an exhaust gas absorption device, heat until reflux occurs, and continue the reaction until the fumaric acid monoester is completely dissolved and the solution is transparent. Continue to keep the temperature at reflux for 50min, and finish the reaction to obtain fumaric acid monoester acid chloride.

[0043...

Embodiment 2

[0046] 1, the preparation of fumaric acid monoester acid chloride

[0047] Add commercially available fumaric acid monoester and thionyl chloride SOCl- 2 and 10 glass beads, install a reflux device and an exhaust gas absorption device, heat until reflux occurs, and continue the reaction until the fumaric acid monoester is completely dissolved and the solution is transparent. Continue to keep the temperature at reflux for 30min, and finish the reaction to obtain fumaric acid monoester acyl chloride.

[0048] 2. Preparation of antibacterial agent

[0049] Add glyceryl monostearate and pyridine in the reaction vessel at a molar ratio of 1:1.5, and the molar ratio of fumaric acid monoacyl chloride to monoglyceride is 1.2:1, and stir to dissolve. Heat to 110°C, slowly add fumaric acid monomethyl chloride dropwise, and continue the reaction for 10 minutes. The reaction product is processed through a series of processes to obtain the antibacterial agent A2 as a light yellow block...

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Abstract

The invention provides an antibacterial agent and a preparation method thereof. Sensitization test shows that the antibacterial agent is no longer sensitive to skin, so that the application scope of the antibacterial agent is greatly enhanced. For example, the antibacterial agent can be applied to materials directly contacted with human body to prepare corresponding antibacterial materials or further directly added into food as a food antibacterial mildew preventive ( in particular food with much oil).

Description

technical field [0001] The invention belongs to the field of antibacterial agents, in particular to an antibacterial agent and a preparation method thereof. Background technique [0002] Dimethyl fumarate (DMF) is a new type of antibacterial agent developed abroad in the 1980s. It has the advantages of broad spectrum, high efficiency, low toxicity, wide applicable pH range, and good chemical stability. In the human body, it can be quickly hydrolyzed by esterase into fumaric acid (a normal component in the body). It is a low-toxic substance. It has a low accumulation of LD50=2240mg / kg for rats (oral), and has no teratogenic or mutagenic effects. Chronic toxicity is low. Its antibacterial effect is better than parabens. In 1981, the US Food and Drug Administration officially approved fumaric acid and its esters as food additives. Dimethyl fumarate was once listed as a trial food preservative in my country, but it had to stop using it in food because it could easily cause al...

Claims

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Application Information

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IPC IPC(8): A01N37/12A01P1/00C07C67/14C07C69/60C07C69/657
Inventor 李全省秦佑斌李金凤高宽
Owner BYD CO LTD
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