37results about How to "Avoid depolymerization" patented technology

The invention is concerned with a kind of rubber disintegrator. There are two roller canisters set in type of revolving on axis seat and they move inside of the roller. The axis of roller canister is fixed on frame of machine through the bearing seat, and the motor and reducer is droved by the revolving on axis seat and they move inside of the roller. The axis of roller canister is fixed on frame of mach axis of the two roller canisters. The said roller canister is made up of some slice type of drills on the axis with lengthways congruence and the drills of two roller canisters are interleaving. The roller canisters move to different directions and send the top of rubber block between the two roller canisters into the drills for cutting. The structure to exit of stuff is outer screen; with exit of stuff and the main part wrapped by the outer screen is the main body of the two roller canisters. The outer screen is a column and the side of it is the screen, the two bottom of it has circumferential rim and the bottom of each rim on the revolving axis seat is driven by transmission framework.

The invention discloses a diketone derivative, as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The derivative comprises compounds in the general formula I and pharmaceutically-acceptable salt, wherein X is C or N; Y is C or N; R1 is one of hydrogen, chlorine, bromine or thiophene; R2 is one of hydrogen, isopropyl or methoxy. The most of compounds of the diketone derivative not only has an inhibiting effect on tau protein polymerization, but also plays a role in stabilizing microtubulin; the diketone derivative can be effectively used for treating the Alzheimer's disease.

The invention discloses immobilized maleic acid cis-trans isomerase and a preparation method and application thereof, and belongs to the technical fields of enzymology and enzyme engineering and the field of biochemical industries. According to the immobilized maleic acid cis-trans isomerase and the preparation method and application thereof, R5 peptide fragments are connected to the N ends of the maleic acid cis-trans isomerase, R5-MaiA is crosslinked through glutaraldehyde, embedding is conducted on the crosslinked R5-MaiA by utilizing silicon reaction liquid, and immobilization of the maleic acid cis-trans isomerase is completed. The immobilized maleic acid cis-trans isomerase (R5-MI-CLEA-Si) with high stability is obtained through the method which is low in cost and easy to operate, the optimum reaction temperature of the immobilized isomerase is 55 DEG C, and the optimum reaction pH is 7.7; on the condition that the temperature is 55 DEG C, the half-life period of the immobilized isomerase is 4 h, the half-life period of the free isomerase is 0.5 h, the stability of the immobilized isomerase is eight times of that of the free isomerase, and after a catalytic reaction is repeated for eight times, the enzyme activity of the immobilized isomerase can be still retained at 75%.

Methods of identifying subjects at increased risk of cancer, based upon detection of biofilms and / or biofilm-associated microbes within a subject, are disclosed. Therapies designed to prevent formation and / or reduce the size of biofilms in a subject identified to be at increased risk of cancer based upon detection of biofilms and / or biofilm-associated microbes are disclosed. In particular embodiments, the invention provides for identification of a subject at elevated risk of developing or having colorectal cancer and / or a colorectal adenoma, based upon detection of a biofilm and / or biofilm-associated bacteria within the gastrointestinal tract of the subject (optionally, within a biopsy specimen and / or stool sample of such subject). Therapies involving administration of an antibiotic agent and / or a probiotic agent to a subject, to prevent or reduce biofilm formation within the gastrointestinal tract of the subject, optionally provided in combination with additional cancer therapy, are also disclosed.

Disclosed herein is a metal enolate initiator for polymerizing isocyanates and a method for polymerizing isocyanates by anionic polymerization using the same, in which the initiator forms a cluster upon the initiation and protects stability of terminal anions at the end of the chain to cause controlled polymerization, thus preventing depolymerizaton and improving reaction time and efficiency without the use of a separate additive.

The invention provides a preparation method of high-performance polysulfone resin. The preparation method includes adding 45-55 parts of 4,4-dichlorodiphenylsulfone, 35-40 parts of salt-forming agent, 80-100 parts of low boiling point organic solvent and 0.01-0.04 parts of 3-fluoro-4-chlorobenzophenone into the reactor, and then 20-60 parts of 4,4'- -dihydroxydiphenylsulfone or bisphenol, injecting nitrogen gas and heating until the temperature inside the reactor rises to 200-210 DEG C, maintaining reaction at constant temperature for 1 to 2 hours, and after the temperature rises to 240-260 DEG C for 4 to 7 hours, adding 0.09-0.16 parts of 3-fluoro-4-chloro benzophenone, reacting 10-20 minutes, then stopping reactor and treating the reactant to obtain high-performance polysulfone resin. The polysulfone resin prepared by the method has high molecular weight, good transparency and heat resistance.

The invention discloses a method for rapidly preparing high-yield double-electricity chitin nanofiber. The method comprises the steps of firstly utilizing concentrated alkaline for carrying out deacetylation on chitin, endowing the chitin with amidogen, and then utilizing a TEMPO-NaClO2-NaClO system for oxidizing, thus obtaining the chitin nanofiber with amidogen and carboxyl at the same time, so that the prepared chitin nanofiber has double-electricity, not only can be dispersed under an acid condition, but also can be dispersed under an alkaline condition, and is favorable for surface modification and design by rich functional groups on the surface; the preparation yield is higher, and large-scale production is facilitated, so that the application range of the chitin nanofiber is expanded.

The invention discloses a pyrrolo-phenothiazine-1,3-diketone containing derivative as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The derivative disclosed by the invention comprises a compound of formula I as shown in the specification, and pharmaceutically applicable salts, wherein in the formula, R1 is hydrogen or chlorine, R2 is hydrogen or methyl, and R3 is one of hydrogen, isopropyl or methoxyl. Most compounds of the type have inhibition functions on tau protein polymerization, have functions of stabilizing tubulin, and can be adopted to effectively treat the Alzheimer's disease.

Methods of identifying subjects at increased risk of cancer, based upon detection of biofilms and / or biofilm-associated microbes within a subject, are disclosed. Therapies designed to prevent formation and / or reduce the size of biofilms in a subject identified to be at increased risk of cancer based upon detection of biofilms and / or biofilm-associated microbes are disclosed. In particular embodiments, the invention provides for identification of a subject at elevated risk of developing or having colorectal cancer and / or a colorectal adenoma, based upon detection of a biofilm and / or biofilm-associated bacteria within the gastrointestinal tract of the subject (optionally, within a biopsy specimen and / or stool sample of such subject). Therapies involving administration of an antibiotic agent and / or a probiotic agent to a subject, to prevent or reduce biofilm formation within the gastrointestinal tract of the subject, optionally provided in combination with additional cancer therapy, are also disclosed.