The invention relates to a medicine for preventing and curing the fish diseases, in particular to an ichthyosporidiumhoferi removal medicine. The invention is characterized in that the medicine is formed by preparing omphalias, flavescent sophora roots, roor of sessile stemonas, carpeium fruits, arecas, chinaberry fruits, abtipyretic dichroas, belamcandas, capillary artemisias, dyers woad roots, and peppers. The medicine consists of Chinese herbal medicines, the environment can not be polluted, the drug resistance is not caused, and the medicine accords with the requirements of environment-friendly food. The invention has the advantages that the cost is low and the curative effect is remarkable, the cost of the medicine added in the one ton feeding stuff is about 400 RMB, but the cost of the medicine which adopts the prior art and is added in one ton feeding stuff in the market is about 800 RMB. Through the trial and the verification, after the diseased fishes take the medicine, the diseases caused by a variety of sporozoons are radically and effectively cured, and the recurrence does not exist after the speedy recovery. The invention has universal use and promotion values.