31 results about "Sodium pantothenate" patented technology

The invention discloses an industrial preparation method of high-purity sodium pantothenate. The method comprises the following steps: adding calcium pantothenate into purified water and dissolving to obtain calcium pantothenate solutions; adding sodium carbonate solutions into sodium pantothenate solutions, performing reaction, filtering and collecting filter liquid; adding active carbon into the filter liquid to be filtered and then filtered by a film; concentrating the liquid filtered by the film and adding ethanol; adding concentrated liquid into which ethanol is added into acetone; growing grains and drying to obtain sodium pantothenate. According to the industrial preparation method, high-temperature drying by distillation and multi-time repeated concentration are not needed, so that the working hours are shortened, and the side reaction is reduced; a special crystallizing condition is not needed, so that the problems that ethanol crystals are difficult to dissolve, easy in oil outflow and difficult to separate out are solved; because the process is simple, the working hours can be shortened by 1-2 times, and the production cost can be reduced by more than 50 percent. The used solvent is low in cost, the defects of high solubility of sodium pantothenate in ethanol and low yield are overcome, and the quality and the yield of the product are guaranteed; moreover, the purity of the product reaches 99.8 percent, and the yield is increased to 90 percent; therefore, the method is more suitable for industrial production.

The invention relates to a freeze-dried preparation of water-soluble vitamin composition for injection without bacteriostatic agent. According to the technical scheme provided by the present invention, the components of this preparation are that each bottle contains: 2.79-3.41 mg of thiamine nitrate, 4.41-5.39 mg of riboflavin sodium phosphate, 36-44 mg of nicotinamide, 4.41-5.39 mg of pyridoxine hydrochloride mg, sodium pantothenate 14.85-18.15mg, sodium vitamin C 101.7-124.3mg, biotin 54-66μg, folic acid 0.36-0.44mg, vitamin B124.5-5.5μg, glycine 270-330mg, edetate disodium 0.45 -0.55 mg. The invention can fundamentally eliminate clinical adverse reactions such as allergy induced by antibacterial agents to users, and improve product safety.

The invention discloses a method for preparing high-purity sodium pantothenate. The method uses β-alanine and alkali as raw materials, reacts in a lower alkanol solvent, and prepares sodium β-alanine, β-alanine Sodium and D-pantolactone are reacted in a lower alkanol solvent to obtain a crude product of sodium pantothenate, and the crude product of sodium pantothenate is purified in 95% ethanol and crystallized to obtain sodium pantothenate. The sodium pantothenate prepared by the invention has the advantages of uniform particle size, good fluidity, low hygroscopicity, simple operation, environmental protection, high yield and high purity, and is suitable for industrial production.

The invention discloses a water-soluble vitamin freeze-dried preparation for injection. 1000 bottles of freeze-dried preparations are prepared from the following raw materials: 2.8-3.4g of thiamine mononitrate, 36-44g of nicotinamide, 4.4-5.4g of pyridoxine hydrochloride, 14.8-18.1g of sodium pantothenate compound, 4.4-5.4g of riboflavin sodium phosphate, 102-124g of sodium ascorbate, 54-66mg of biotin, 0.36-0.44g of folic acid, 4.5-6.0mg of vitamin B12, 0.4-0.6g of methyl p-hydroxybenzoate, 280-320g of glycine, 0.4-0.6g of ethylene diamine tetraacetic acid disodium salt and 2000-3000ml of water for injection. The stability of existing sodium pantothenate is obviously improved by the obtained sodium pantothenate compound, thus ensuring that the sodium pantothenate containing water-soluble vitamin freeze-dried preparation for injection has ideal stability and curative effect and further ensuring medication safety of the patients.

The invention relates to a drug combination of water-soluble multivitamins with the best proportion containing the new efficient bacteriostatic agent and a preparation method thereof. The drug combination includes, for example, the preferable weight portion ratio is: 0.1 portion of compound distributed phydroxy sodium formate, 3.1 portions of vitamin B1, 4.9 portions of vitamin B2, 40 portions ofnicotinamide, 4.9 portions of vitamin B6, 16.5 portions of sodium pantothenate, 113 portions of sodium vitamin C, 0.06 portion of biotin, 0.4 portion of folic acid and 0.005 portion of vitamin B12. Used for treating the lack of vitamins or preventing the deficiency of vitamins, the drug combination contains the new efficient bacteriostatic agent in very low amount, eliminates the side effects of the bacteriostatic agent on human bodies and ensures the safety of the bacteriostatic agent. Simultaneously, the vitamin content ratios of the components are all very low, thus solving the adverse reactions caused by the excess water-soluble multivitamins or the generated potential toxicity. The drug combination of the invention can be made into injections or lyophilized agents, produced through the conventional process and equipment and has the advantages of easy industrialization, stable quality and low cost.

The invention discloses a water-soluble vitamin composition freeze-drying preparation for injection. The freeze-drying preparation comprises the following raw materials and is prepared into 1,000 bottles: 2.8 to 3.4 grams of thiamine mononitrate, 36 to 44 grams of nicotinamide, 4.4 to 5.4 grams of pyridoxine hydrochloride, 14.8 to 18.1 grams of sodium pantothenate, 4.4 to 5.4 grams of riboflavin sodium phosphate, 102 to 124 grams of sodium vitamin C, 54 to 66 milligrams of biotin, 0.36 to 0.44 gram of folic acid, 124.5 to 6.0 milligrams of vitamin B, and 0.4 to 0.6 gram of methyl-p-hydroxy benzoate, wherein the nicotinamide is nicotinamide hydrate, and the sodium pantothenate is sodium pantothenate hydrate. The water-soluble vitamin for injection has adjustable grain size, concentrated grain size distribution, glabrous surface, high product fluidity, greatly improved stability and high dissolution rate, and a preparation process of the preparation is simple and is favorable for popularization and use.

The invention relates to a water-soluble vitamin pharmaceutical composition for injection. The water-soluble vitamin pharmaceutical composition for injection is prepared from 3.1g of thiamine mononitrate, 40g of nicotinamide, 16.5g of sodium pantothenate, 60mg of biotin, 5.0mg of vitamin B12, 0.5g of disodium ethylene diamine tetraacetate, 4.9g of riboflavin sodium phosphate, 4.9g of pyridoxine hydrochloride, 113g of sodium vitamin C, 0.4g of folic acid, 300g of glycine, 0.5g of methyl parahydroxybenzoate, 1.2g of poloxamer 188, 0.5g of sodium lactate, 1.0g of L-malic acid and water for injection, wherein the water for injection is added until the total volume is 2000ml. The water-soluble vitamin pharmaceutical composition for injection, disclosed by the invention, is good in stability and greatly improved in medication safety.