Bacteriostat-free water-soluble vitamin freeze-dried preparation for injection
A technology for water-soluble vitamins and freeze-dried preparations, which can be used in medical preparations containing active ingredients, freeze-dried delivery, organic active ingredients, etc., and can solve the problems of inducing allergic reactions, reducing the incidence and severity of clinical adverse reactions, etc. Achieve the effect of eliminating the storage process and preventing recontamination
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Embodiment 1
[0032] Accurately weigh the following raw materials: thiamine nitrate 3.1mg, riboflavin sodium phosphate 4.9mg, nicotinamide 40mg, pyridoxine hydrochloride 4.9mg, sodium pantothenate 16.5mg, vitamin C sodium 113mg, biotin 60μg, folic acid 0.4mg, vitamin B 12 5.0μg, glycine 300mg, disodium edetate 0.5mg.
[0033] Add the above-mentioned raw materials one by one into water for injection not exceeding 60°C, stir to dissolve, and adjust the total weight with water for injection; the dissolution process should be protected from light, and always protected by sterile filtered nitrogen; the final pH of the liquid is 5.6- 6.1;
[0034] The liquid medicine is sterile filtered to the receiving tank and protected with nitrogen;
[0035] Fill the sterile-filtered medicinal liquid into cleaned and sterilized vials within 12 hours with an automatic filling machine, and the filling volume of each vial is 2ml; stopper the upper half of the vial;
[0036] Immediately after filling, freeze-d...
Embodiment 2
[0041] Accurately weigh the following raw materials: 2.79mg of thiamine nitrate, 4.41mg of riboflavin sodium phosphate, 36mg of nicotinamide, 4.41mg of pyridoxine hydrochloride, 14.85mg of sodium pantothenate, 101.7mg of sodium vitamin C, 54μg of biotin, 0.36mg of folic acid, Vitamin B 12 4.5μg, glycine 270mg, edetate disodium 0.45mg; processing method is the same as above
Embodiment 3
[0043] Accurately weigh the following raw materials: 3.41 mg of thiamine nitrate, 5.39 mg of riboflavin sodium phosphate, 44 mg of nicotinamide, 5.39 mg of pyridoxine hydrochloride, 18.15 mg of sodium pantothenate, 124.3 mg of sodium vitamin C, 66 μg of biotin, 0.44 mg of folic acid, Vitamin B 12 5.5μg, 330mg glycine, 0.55mg disodium edetate; the treatment method is the same as above.
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