Water-soluble vitamin composition freeze-drying preparation for injection
A technology of water-soluble vitamins and freeze-dried preparations, which is applied in the direction of freeze-dried transportation, drug combination, and active ingredients of heterocyclic compounds, which can solve the problems of no water-soluble vitamin raw materials, etc., and is conducive to popularization and use, and the particle size distribution is concentrated , The effect of simple preparation process
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Embodiment 1
[0052] The preparation of embodiment 1 sodium pantothenate hydrate
[0053] At room temperature, dissolve 16.5g of anhydrous sodium pantothenate in 85ml of 75% ethanol solution, distill under normal pressure and then distill under reduced pressure until the compound is precipitated, and dry the compound in vacuum at 35°C for 2 hours to obtain sodium pantothenate dihydrate things. The moisture content measured by the combination of Karl Fischer moisture determination method and thermogravimetric analysis is within the error range with the theoretical moisture content of the dihydrate. Moisture content in sodium pantothenate hydrate is 12.98% (see figure 2 ).
Embodiment 2
[0054] The preparation of embodiment 2 sodium pantothenate hydrate
[0055] At room temperature, dissolve 16.5g of anhydrous sodium pantothenate in 85ml of 80% ethanol solution, distill at normal pressure and then distill under reduced pressure until the compound is precipitated, and dry the compound in vacuum at 30°C for 1.5 hours to obtain sodium pantothenate dihydrate things. The moisture content measured by the combination of Karl Fischer moisture determination method and thermogravimetric analysis is within the error range with the theoretical moisture content of the dihydrate. The water content in sodium pantothenate hydrate is 12.97%.
Embodiment 3
[0056] The preparation of embodiment 3 sodium pantothenate hydrate
[0057] At room temperature, dissolve 16.5g of anhydrous sodium pantothenate in 85ml of 80% ethanol solution, distill at normal pressure and then distill under reduced pressure until the compound is precipitated, and dry the compound in vacuum at 50°C for 1.5 hours to obtain sodium pantothenate dihydrate things. The moisture content measured by the combination of Karl Fischer moisture determination method and thermogravimetric analysis is within the error range with the theoretical moisture content of the dihydrate. The water content in sodium pantothenate hydrate is 12.99%.
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