Industrial preparation method of high-purity sodium pantothenate

Abstract

The invention discloses an industrial preparation method of high-purity sodium pantothenate. The method comprises the following steps: adding calcium pantothenate into purified water and dissolving to obtain calcium pantothenate solutions; adding sodium carbonate solutions into sodium pantothenate solutions, performing reaction, filtering and collecting filter liquid; adding active carbon into the filter liquid to be filtered and then filtered by a film; concentrating the liquid filtered by the film and adding ethanol; adding concentrated liquid into which ethanol is added into acetone; growing grains and drying to obtain sodium pantothenate. According to the industrial preparation method, high-temperature drying by distillation and multi-time repeated concentration are not needed, so that the working hours are shortened, and the side reaction is reduced; a special crystallizing condition is not needed, so that the problems that ethanol crystals are difficult to dissolve, easy in oil outflow and difficult to separate out are solved; because the process is simple, the working hours can be shortened by 1-2 times, and the production cost can be reduced by more than 50 percent. The used solvent is low in cost, the defects of high solubility of sodium pantothenate in ethanol and low yield are overcome, and the quality and the yield of the product are guaranteed; moreover, the purity of the product reaches 99.8 percent, and the yield is increased to 90 percent; therefore, the method is more suitable for industrial production.

Description

technical field [0001] The invention relates to an industrialized preparation method of water-soluble vitamin sodium pantothenate. Background technique [0002] Sodium pantothenate, English name D-Pantothenic Acid Sodium Salt, alias D-pantothenic acid sodium, chemical name (R)-N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)- Beta-alanine, monosodium salt, is the sodium salt form of pantothenic acid. Pantothenic acid, also known as pantothenic acid and vitamin B3, is a kind of vitamin B family. It can help cells form, maintain normal development and the development of the central nervous system, and maintain the normal function of the adrenal gland. It is indispensable when fat and sugar are converted into energy. It is also an essential substance for antibody synthesis and human body's utilization of aminobenzoic acid and choline. There are two forms of pantothenic acid, calcium salt and sodium salt, commonly used clinically. Calcium pantothenate and its tablets have been recor...

AI Technical Summary

Problems solved by technology

Repeated heating consumes a lot of heat, heat loss is large, time-consuming and labor-intensive; and in the whole synthesis process, there is no effective purification method, and the product is evaporated to dryness so that impurities (new impurities and unreacted raw materials) remain in the crude product to the maximum extent. result in low product purity

[0011] Third, the crude product is recrystallized with absolute ethanol, and the total yield is only 44%

It is difficult to dissolve during recrystallization, easy to produce oil, time-consuming, waste of manpower, material and financial resources, and low yield. In addition, raw materials such as calcium pantothenate and sodium carbonate remain in the crude product, and the two are slightly soluble in ethanol, so recrystallization with ethanol cannot Effective removal, the purpose of crystallization and impurity removal is not achieved, the product quality cannot be guaranteed, and it is not suitable for industrial production

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