46 results about "Molecular stability" patented technology

The invention relates to a mixed absorbent for gathering or separating carbon dioxide from a gas mixture, which mainly comprises the following components in percentage by weight: 21 to 45 percent of diethylethylenediamine, 5.0 to 9.9 percent of primary amine containing one nitrogen atom and / or secondary amine containing one nitrogen atom, and the balance of water. The absorbent has high solubility and good desorption effect on low-pressure carbon dioxide, simultaneously absorbs less reaction heat, and has low energy consumption for gathering or separating the low-pressure carbon dioxide; because the diethylethylenediamine is tertiary amine and has high boiling point and better molecular stability than the primary amine and secondary amine, so the degradation loss of a solvent in the using process can be greatly reduced. The mixed absorbent can be used for gathering or separating various normal-pressure gas mixtures, such as carbon dioxide in flue gas discharged from coal fired power plants, and enterprises in the steel, cement, petrochemical engineering and other industries.

The invention relates to a preparation method for an organic compound by using a seven-element ring as a core structure and an application thereof on an OLED, and belongs to the technical field of organic photoelectric materials. The organic compound has better molecular stability. A prepared OLED device has excellent luminous efficiency, and is capable of meeting requirements of a device manufacturer well.

The invention relates to a mixed absorbing agent for catching or separating carbon dioxide from gas mixture, which mainly comprises the components by weight percent: 10-50wt% of 3-dimethyl amino-1-propyl alcohol, 5-10wt% of primary amine and / or secondary amine and balance water. The absorbing agent has high solubility for low-pressure carbon dioxide, good desorbing effect, lower reaction heat of absorption reaction and lower energy consumption for catching or separating the carbon dioxide; and as the 3-dimethyl amino-1-propyl alcohol is a tertiary amine and has high boiling point and better molecular stability than primary amine and secondary amine, so that the mixed absorbing agent can greatly reduce the degradation consumption of solvent in the using process, has good catching effect, and can be used for catching or separating the carbon dioxide in various gas mixtures such as flue gas, refinery gas, natural gas, synthesis gas, shift gas, hydrogen preparation gas and the like.

The present invention relates to methods and compositions for enhancing folding and stability of biological molecules. In particular, the present invention relates to methods and compositions for identifying biological molecules with enhanced stability. The present invention further relates to host cells that confer enhanced stability to biological molecules expressed therein.

This invention relates to the field of recombinant antibody technology. It provides novel recombinant IgY antibody constructs for diagnostic and therapeutical applications. The bivalent antibody constructs display a heterotetrameric or homodimeric format stabilized by disulfide bonds. The constant heavy chain domains CH2-CH4 are partly or completely of avian origin, whereas the VH, VL, CL, and CH1 domains as well as the hinge region may be of avian origin or derived from any other species. The invention allows to combine the advantages of IgY antibodies with those of established mammalian monoclonal antibodies. IgY antibody constructs comprising nonglycosylated IgY constant heavy chain domains allow to reduce unwanted interactions with C-type lectins, e.g., in human sera. Furthermore, chimeric IgY antibody containing mammalian VH, VL, CL, and CH1 domains as well as a mammalian hinge region provide a higher molecular stability than IgY antibodies in acidic conditions and, thereby, are especially suited for peroral therapeutic applications.

The invention discloses a recombinant feline herpesvirus type 1 gB-gD protein and application thereof. The recombinant feline herpesvirus type 1 gB-gD protein comprises: the first protein having the sequence shown in SEQ ID NO:2; and / or, the second protein having the sequence shown in SEQ ID NO:6. The vaccine comprises the recombinant feline herpesvirus type 1 gB-gD protein and a pharmaceutically acceptable carrier. The recombinant feline herpesvirus type 1 gB-gD protein provided by the invention has a long half-life, high molecular stability, can form dimers, especially heterodimers, and has strong immunogenicity. The preparation of large-scale serum-free suspension culture in bioreactor not only has high expression level and good protein immunogenicity, but also has the advantages of easy quality control, batch-to-batch stability, and low production cost.

The present invention relates to a new coronavirus single-chain antibody, a quality control product and a preparation method, which include a light chain variable region and a heavy chain variable region in sequence from the N segment to the C terminal, and the amino acid sequence of the light chain variable region is as shown in SEQ As shown in ID NO:1, the amino acid sequence of the heavy chain variable region is shown in SEQ ID NO:2. The novel coronavirus single-chain antibody of the present invention has high sensitivity and good stability, and is very suitable for the preparation of quality control products. Moreover, on the basis of this variable region sequence, further use gene recombination technology to construct a human-mouse chimeric IgM antibody without a CH1 fragment, thereby improving molecular stability and specific binding ability. The novel coronavirus single-chain antibody prepared by the invention can be applied to a chemiluminescence platform for quality control detection, can effectively measure activity, and can overcome the defects of poor detection sensitivity and low specificity of general 2019‑nCoV IgM antibodies.

The invention belongs to the technical field of chemical detection, and relates to a rhodamine-benzothiazole functional photosensitive probe and its synthesis method and application. The rhodamine-benzothiazole functional photosensitive probe has a structure that can be used for ClO ‑ Detection and ClO in cells ‑ detection. The rhodamine-benzothiazole functionalized photosensitive probe provided by the present invention has a six-membered spironolide hydrazide structure, has high molecular stability of the probe, increases the reactive binding sites of the probe, and has good bio-affinity, and can be used in environment and environment. ClO in biological cells ‑ The detection has the characteristics of good anti-interference ability, short response time, long fluorescence duration, wide applicable pH range, high detection sensitivity and wide detection concentration range, and has important scientific research value and broad application and promotion prospects.

The invention discloses a curcumin micelle nasal solution which contains curcumin used as a main drug, a preservative and an isoosmotic adjusting agent. The curcumin micelle nasal solution is characterized by comprising a poly(N-vinylcaprolactam)-polyvinyl acetate-polyethylene glycol copolymer, a medicinal polyethylene glycol auxiliary material and RGD peptide which are used as medicinal excipients. The mass ratio of the main drug curcumin to the poly(N-vinylcaprolactam)-polyvinyl acetate-polyethylene glycol copolymer medicinal excipient is 1:12-1:20. The mass ratio of the medicinal polyethylene glycol auxiliary material to the poly(N-vinylcaprolactam)-polyvinyl acetate-polyethylene glycol copolymer medicinal excipient is 1:20-1:40. The mass ratio of RGD peptide to the medicinal polyethylene glycol auxiliary material is 1:2-1:4. According to the prepared curcumin micelle nasal solution, curcumin has good solubility in an aqueous solution. By a preparation method of the curcumin micelle nasal solution, water solubility of curcumin is solved, and molecular stability of curcumin is raised. Meanwhile, particle size of the micelle is adjusted to an appropriate particle size range (150-220 nm), and stability of the micelle aqueous solution is enhanced.