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Rhodamine-benzothiazole functionalized photosensitive probe and its synthesis method and application

A benzothiazole and functional technology, applied in the field of chemical detection, to achieve strong applicability, broad application and promotion prospects, and wide applicable pH range

Active Publication Date: 2022-03-29
XIAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to solve the problems existing in the existing rhodamine-based probes, the present invention provides a rhodamine-benzothiazole functionalized photosensitive probe and its preparation method and application. High sensitivity, increased reaction binding sites of probes, good bio-affinity, can be used in ClO in the environment and biological cells - Detection, with the characteristics of good anti-interference ability, short response time, long fluorescence duration, wide applicable pH range, high detection sensitivity and wide detection concentration range, has important scientific research value and broad application and promotion prospects

Method used

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  • Rhodamine-benzothiazole functionalized photosensitive probe and its synthesis method and application
  • Rhodamine-benzothiazole functionalized photosensitive probe and its synthesis method and application

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Embodiment

[0053] The synthetic method route of the rhodamine-benzothiazole functionalized photosensitive probe provided in this example is:

[0054]

[0055] The specific synthetic process of the present embodiment is:

[0056] 1) In a clean and absolutely dry 50mL round bottom flask, accurately weigh 0.4780g of dry rhodamine B (1.000mmol) and add it, measure 5.0mL of dry 1,2-dichloroethane as a solvent, add a little Shake to dissolve Rhodamine B completely, then measure 1.0mL phosphorus oxychloride POCl 3 Add it into the reaction bottle, add a magnetic stirrer, use a reflux condensing device, and install a drying tube and an exhaust gas absorption device, set the reaction temperature to 90°C, and heat to reflux for about 8 hours. During the reaction, gas with a pungent smell is emitted; after the reaction is completed, the reaction bottle is cooled to room temperature, and then the solvent 1,2-dichloroethane and the unreacted phosphorus oxychloride are evaporated with a rotary evap...

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Abstract

The invention belongs to the technical field of chemical detection, and relates to a rhodamine-benzothiazole functional photosensitive probe and its synthesis method and application. The rhodamine-benzothiazole functional photosensitive probe has a structure that can be used for ClO ‑ Detection and ClO in cells ‑ detection. The rhodamine-benzothiazole functionalized photosensitive probe provided by the present invention has a six-membered spironolide hydrazide structure, has high molecular stability of the probe, increases the reactive binding sites of the probe, and has good bio-affinity, and can be used in environment and environment. ClO in biological cells ‑ The detection has the characteristics of good anti-interference ability, short response time, long fluorescence duration, wide applicable pH range, high detection sensitivity and wide detection concentration range, and has important scientific research value and broad application and promotion prospects.

Description

technical field [0001] The invention belongs to the technical field of chemical detection, and relates to a rhodamine-benzothiazole functionalized photosensitive probe, a synthesis method and an application. Background technique [0002] Reactive oxygen species (ROS), including superoxide radicals (O 2 ·- ), hydroxyl radical (OH·), peroxyl radical (ROO·), hydrogen peroxide (H 2 o 2 ), singlet oxygen ( 1 o 2 ) and hypochlorous acid and hypochlorite (HClO / ClO - ), are closely related to numerous physiological and pathological processes such as signal conversion, neuropathic injury, inflammation and carcinogenesis. Hypochlorous acid and hypochlorite exist together to regulate physiological pH and are an important ROS. As a very effective antibacterial agent and bleaching agent in daily life, hypochlorous acid is widely used in the disinfection of water quality such as tap water and swimming pools. In cells, it can quickly oxidize the amino groups in amino acids to chlor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D491/107C09K11/06G01N21/64
CPCC07D491/107C09K11/06G01N21/6428C09K2211/1037C09K2211/1048
Inventor 杨征许甜甜刘向荣赵顺省杨再文加晓丹
Owner XIAN UNIV OF SCI & TECH
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