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Rhodamine-benzothiazole functionalized photosensitive probe as well as synthesis method and application thereof

A technology of benzothiazole and synthesis method, which is applied in the field of chemical detection to achieve the effects of improving stability, broad application and promotion prospects, and wide applicable pH range

Active Publication Date: 2021-02-09
XIAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems existing in the existing rhodamine-based probes, the present invention provides a rhodamine-benzothiazole functionalized photosensitive probe and its preparation method and application. High sensitivity, increased reaction binding sites of probes, good bio-affinity, can be used in ClO in the environment and biological cells - Detection, with the characteristics of good anti-interference ability, short response time, long fluorescence duration, wide applicable pH range, high detection sensitivity and wide detection concentration range, has important scientific research value and broad application and promotion prospects

Method used

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  • Rhodamine-benzothiazole functionalized photosensitive probe as well as synthesis method and application thereof
  • Rhodamine-benzothiazole functionalized photosensitive probe as well as synthesis method and application thereof
  • Rhodamine-benzothiazole functionalized photosensitive probe as well as synthesis method and application thereof

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Embodiment

[0053] The synthetic method route of the rhodamine-benzothiazole functionalized photosensitive probe provided in this example is:

[0054]

[0055] The specific synthetic process of the present embodiment is:

[0056] 1) In a clean and absolutely dry 50mL round bottom flask, accurately weigh 0.4780g of dry rhodamine B (1.000mmol) and add it, measure 5.0mL of dry 1,2-dichloroethane as a solvent, add a little Shake to dissolve Rhodamine B completely, then measure 1.0mL phosphorus oxychloride POCl 3 Add it into the reaction bottle, add a magnetic stirrer, use a reflux condensing device, and install a drying tube and an exhaust gas absorption device, set the reaction temperature to 90°C, and heat to reflux for about 8 hours. During the reaction, gas with a pungent smell is emitted; after the reaction is completed, the reaction bottle is cooled to room temperature, and then the solvent 1,2-dichloroethane and the unreacted phosphorus oxychloride are evaporated with a rotary evap...

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Abstract

The invention belongs to the technical field of chemical detection, and relates to a rhodamine-benzothiazole functionalized photosensitive probe, and a synthesis method and application thereof. The structure of the rhodamine-benzothiazole functionalized photosensitive probe can be used for ClO<-> detection and detection of ClO<-> in cells. The rhodamine-benzothiazole functionalized photosensitiveprobe provided by the invention has a six-membered spirohydrazide structure, the stability of probe molecules is high, the reaction binding sites of the probe are increased,and good biocompatibility is obtained; and the probe can be used for detecting ClO<-> in environment and biological cells, has the characteristics of good anti-interference capability, short response time, long fluorescence duration, wide pH application range, high detection sensitivity and wide detection concentration range, and presents important scientific research value and wide application and popularization prospects.

Description

technical field [0001] The invention belongs to the technical field of chemical detection, and relates to a rhodamine-benzothiazole functionalized photosensitive probe, a synthesis method and an application. Background technique [0002] Reactive oxygen species (ROS), including superoxide radicals (O 2 ·- ), hydroxyl radical (OH·), peroxyl radical (ROO·), hydrogen peroxide (H 2 o 2 ), singlet oxygen ( 1 o 2 ) and hypochlorous acid and hypochlorite (HClO / ClO - ), are closely related to numerous physiological and pathological processes such as signal conversion, neuropathic injury, inflammation and carcinogenesis. Hypochlorous acid and hypochlorite exist together to regulate physiological pH and are an important ROS. As a very effective antibacterial agent and bleaching agent in daily life, hypochlorous acid is widely used in the disinfection of water quality such as tap water and swimming pools. In cells, it can quickly oxidize the amino groups in amino acids to chlor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D491/107C09K11/06G01N21/64
CPCC07D491/107C09K11/06G01N21/6428C09K2211/1037C09K2211/1048
Inventor 杨征许甜甜刘向荣赵顺省杨再文加晓丹
Owner XIAN UNIV OF SCI & TECH
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