50results about How to "High molecular stability" patented technology

The synthesis of deuterated analogues of rapamycin is disclosed together with a method for use for inducing immunosupression and in the treatment of transplantation rejection, graft vs host disease, autoimmune diseases, diseases of inflammation leukemia / lymphoma, solid tumors, fungal infections, hyperproliferative vascular disorders. Also described is a method for the synthesis of water soluble deuteratred rapamycin compounds and their use as described above.

The present invention relates to an Exendin 4 polypeptide fragment, which has hypoglycemic activity, and can be used for the treatment of type II diabetes mellitus. The polypeptide sequence described herein is HGEGTX1TSDLSKQX2EEEAVX3LFIEWLKNGX4PX5, where X1 represents Phe or Tyr, X2 represents Met, Ile or Leu, X3 represents Lys, X4 represents Gly or deletion, X5 represents Arg or deletion. Additionally, the present invention relates to a method for the Exendin 4 polypeptide fragment preparation.

The invention discloses a curcumin micelle nasal solution which contains curcumin used as a main drug, a preservative and an isoosmotic adjusting agent. The curcumin micelle nasal solution is characterized by comprising a poly(N-vinylcaprolactam)-polyvinyl acetate-polyethylene glycol copolymer, a medicinal polyethylene glycol auxiliary material and RGD peptide which are used as medicinal excipients. The mass ratio of the main drug curcumin to the poly(N-vinylcaprolactam)-polyvinyl acetate-polyethylene glycol copolymer medicinal excipient is 1:12-1:20. The mass ratio of the medicinal polyethylene glycol auxiliary material to the poly(N-vinylcaprolactam)-polyvinyl acetate-polyethylene glycol copolymer medicinal excipient is 1:20-1:40. The mass ratio of RGD peptide to the medicinal polyethylene glycol auxiliary material is 1:2-1:4. According to the prepared curcumin micelle nasal solution, curcumin has good solubility in an aqueous solution. By a preparation method of the curcumin micelle nasal solution, water solubility of curcumin is solved, and molecular stability of curcumin is raised. Meanwhile, particle size of the micelle is adjusted to an appropriate particle size range (150-220 nm), and stability of the micelle aqueous solution is enhanced.

The invention provides a composition for increasing fertilizer absorption and utilization rate and application thereof. The composition comprises orange essential oil, an emulsifier and an organic solvent, wherein the orange essential oil comprises, by mass percentage, 10-30% of grapefruit essential oil and 50-70% of orange peel essential oil. A method for increasing the fertilizer absorption andutilization rate includes: adding the composition into fertilizer, evenly mixing, and applying the fertilizer to crops. The composition has the advantages that the orange essential oil in the composition can increase molecular stability in humic acid, the problems of alginic acid fertilizer gas expansion and solid fertilizer moisture absorption are solved, the orange essential oil can carry fertilizer components to fast penetrate leaves to enter the bodies of plants, and the absorption and utilization rate of humic acid fertilizer, alginic acid fertilizer, amino acid fertilizer, oligosaccharide fertilizer and fish protein fertilizer can be increased.

Specific antibodies against N-procalcitonin, peptides, genetic constructions and methods for the obtainment of the peptides used in the obtainment of the antibodies. These antibodies can be used for preparing drugs, or diagnostic kits for diseases that develop with systemic inflammatory response or metabolic stress.

Disclosed are compositions of matter, methods, and protocols useful for treatment of cancer through induction of anti-angiogenic immune responses. The invention provides means of differentiating tumor cells directly into endothelial or endothelial-like cells and utilizing said cells as immunogens for the purpose of inducing immunity against blood vessels feeding tumors. In one embodiment glioma cells are cultured under hypoxic conditions in the presence of endothelial-differentiating factors. In another embodiment, PECAM-1 positive cells are derived from a tumor mass or cell line and utilized as an antigenic source to induce immunity towards tumor derived endothelial cells, endothelial-like cells, and tumor vascular channels.

A capturing molecule having an association containing a plurality of polypeptide chains that specifically bind to different sites of a target substance, characterized in that each of the polypeptide chains has a domain having a hypervariable loop structure at a binding site binding to the target substance and an association portion for forming the association, and the polypeptide chains are associated via the association portions present in the polypeptide chains.

The present invention relates to a method for producing of a cell and / or tissue and / or disease phase specific medicament against against chronic inflammatory diseases.Disease, cell type, tissue and / or stage specific proteins and nucleic acids are identified with regard to their modified expression pattern and the corresponding nucleic acids are analyzed as possible attack targets for DNAzymes or siRNA. What follows is a design of active specific DNAzymes and siRNA which bind to the target sequence and cleave it such that a medicament against chronic inflammatory diseases and autoimmune diseases is provided.

The invention provides an environmental-friendly wooden anti-glare plate and a manufacturing method thereof, wherein the manufacturing method comprises following steps: immersing wooden single plates into an impregnating agent for immerse processing and the weight ratio between the weight of the wooden single plates before the immerse processing and the weight of the wooden single plates after the immerse process is 1:1.2 to 1.4; processing the sequentially stacked wooden single plates with heat-press after the plurality of the wooden single plates are immersed; the impregnating agent comprises water and phenolic resin; and the weight part ratio of the water and the phenolic resin is 1:1 to 3. The environmental-friendly wooden anti-glare plate provided herein has the advantages of light weight, high strength, strong aging resistance and acid and alkali corrosion resistance; the environmental-friendly wooden anti-glare plate can be used to effectively replace an anti-glare plate on an expressway, thus the problems of poor aging-resistance performance of the anti-glare plate and secondary damage in a car accident; the running efficiency of expressways in our country is improved; the maintenance and running cost are reduced, thus the expressways can be ran with low carbon, safety, high efficiency and low cost; and the sustainable development of the expressways is promoted.

The invention relates to a method for the production of a cell and / or tissue and / or disease phase specific medicament against chronic inflammatory diseases. Disease, cell-type, tissue and / or stage specific proteins and nucleic acids are identified with regard to the modified expression pattern and the corresponding nucleic acids are analyzed as possible attack targets for DNAzymes or siRNA. What follows is a design of active specific DNAzymes and siRNA which bind to the target sequence and cleave it such that a medicament against chronic inflammatory diseases and auto-immune diseases is provided.

Remedies for dry eye and diseases associated with dry eye which contain as the active ingredient peptides represented by the general formula (I): H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-X1-Gln-X2-Ala-Val-X3-X4-Tyr-Leu-X5-X6 (I) wherein X1, X3 and X4 represent Lys or Arg, respectively; X2 represents Met, Leu or nLeu; X5 represents a chemical bond, Asn, Asn-Ser, Asn-Ser-Ile, Asn-Ser-Ile-Leu or Asn-Ser-Ile-Leu-Asn-X7 (wherein X7 represents a chemical bond, Gly, etc.); and X6 represents -OH or -NH2, or pharmaceutically acceptable salts thereof.

A method of treating or preventing cardiovascular disease which comprises administering a therapeutically effective amount of at least one n-3 DPA-derived resolvin and / or upregulating or increasing the biosynthesis or activity of at least one n-3 DPA-derived resolvin. n-3 DPA-derived resolvins are normally regulated diurnally in the body and are linked to activation of platelets and leucocytes and formation of platelet-leukocyte aggregates. Dysfunctional regulation of n-3 DPA-derived resolvins may lead to systemic inflammation because of excessive inflammation-inducing eicosanoids, especially in the early hours of the morning. Further, decreased 5-LOX / 15-LOX expression and increased systemic adenosine concentrations are found to be associated with reduced resolvin levels and increased risk of cardiovascular disease. n-3 DPA-derived resolvins are administered to achieve maximum absorption in the early hours. Also disclosed are n-3 DPA-derived resolvins for use in the treatment or prevention of cardiovascular disease, and methods for measuring the levels of n-3 DPA-derived resolvins and / or the expression or activity of adenosine or 5-LOX / 15-LOX in biological samples obtained from a subject for assessing the subject's risk of cardiovascular disease.

A composition of L-ascorbic acid derivatives is described comprising L-ascorbic acid and lysine or lysine moieties, wherein L-ascorbic acid is covalently bound to the lysine or lysine moieties. The composition so described is used to prevent the degradation of extracellular matrix, stabilize connective tissue, is used to as an antioxident, and is used for treating damage to skin comprising applying the topical composition to the skin.

A composition of L-ascorbic acid derivatives is described comprising L-ascorbic acid and lysine or lysine moieties, wherein L-ascorbic acid is covalently bound to the lysine or lysine moieties. The composition so described is used to prevent the degradation of extracellular matrix, stabilize connective tissue, is used to as an antioxidant, and is used for treating damage to skin comprising applying the topical composition to the skin.

The present disclosure provides a sound absorbing material. The sound absorbing material comprising MFI-structural-type molecular sieves, the MFI-structural-type molecular sieves comprises frameworks and extra-framework cations, the framework comprising SiO2 and a metal oxide MxOy containing a metal element M, wherein a molar ratio of Si / M is between 220 and 600 in the framework, the metal element M comprises aluminum, and the extra-framework cations are at least one of hydrogen ions, alkali metal ions and alkaline earth metals. The present also provides a method for preparing a sound absorbing material and a speaker box using the sound absorbing material.

It is intended to provide a novel amyloid protein (human variant amyloid protein) useful as an antigen molecule or the like for improving a vaccine therapy. This human variant amyloid protein is a protein with deletion of Glu at 22nd, Ala at 21st, or Asp at 23rd in a normal (wildtype) amyloid protein (Aβ1-40, Aβ1-42, or Aβ1-43) consisting of 40, 42, or 43 amino acids.

A composition of L-ascorbic acid derivatives is described comprising L-ascorbic acid and lysine or lysine moieties, wherein L-ascorbic acid is covalently bound to the lysine or lysine moieties. The composition so described is used to prevent the degradation of extracellular matrix, stabilize connective tissue, is used to as an antioxident, and is used for treating damage to skin comprising applying the topical composition to the skin.

The invention discloses a novel compound and application thereof in an organic electroluminescent display device. The chemical structure of the compound is as shown in the specification, X is selected from C, O, S or N, and Cy is naphthenic base with 5-30 carbon atoms; R(a) and R(b) respectively represent a and b independent R substituents; R is hydrogen, deuterium, substituted or unsubstituted alkyl or alkoxy with the carbon atom number of 1-20, substituted or unsubstituted aryl with the ring-forming carbon atom number of 5-60, substituted or unsubstituted heteroaryl with the ring-forming carbon atom number of 5-60, substituted or unsubstituted fluoroalkyl with the carbon atom number of 1-20, or cyano; and Ar1 to Ar3 are respectively and independently substituted or unsubstituted arylene with the ring-forming carbon atom number of 5-60 and substituted or unsubstituted heteroarylene with the ring-forming carbon atom number of 5-60. The novel compound is good in film-forming property, crystallinity resistance and molecular stability when being used as a hole transport layer material, and the service life of a device is greatly prolonged.

The invention relates to a preparation method of a high-temperature-resistant gas-sensitive material and belongs to the technical field of gas sensor technologies. The method comprises the following steps: taking corn straws, corn leaves and rice hulls as raw materials and putting the same into hydrochloric acid to soak and dissolve part of tissue fibers, separating the plant fibers, corroding byusing citric acid so as to modify a fiber tube, so that the roughness degree of the tube wall of the fiber tube is increased, meanwhile, introducing a large amount of carboxyl group chelating zinc ions and generating nano-scale zinc oxide molecules through the reaction of diethylamine, adsorbing a large amount of zinc ions by the plant fibers through chelating so as to enable the generated nano-zinc oxide to be embedded into the plant fiber tube, and expanding to form holes, thereby increasing the contact area between the nano-scale zinc oxide and the air, and then, carbonizing the plant fibers, so that the zinc oxide molecules exist in the carbon environment, and the zinc oxide is difficult to corrode by external substances, simultaneously, the heat-conduction heat resistance of the carbon fiber is good, the heat resistance of the gas-sensitive material can be obviously improved, and a good application prospect is achieved.

The invention discloses a polyimide waterborne epoxy coating. The polyimide waterborne epoxy coating comprises the following components in parts by weight: 10 parts of waterborne epoxy resin, 50-100 parts of polyimide waterborne epoxy resin, 0.5-2 parts of a curing agent, 0.5-2 parts of a flatting agent, 0.1-1 part of a dispersing agent, 0.2-2 parts of a defoaming agent, 10-20 parts of pigment, 10-100 parts of filler and 50-100 parts of water. A preparation method of the polyimide water-borne epoxy resin comprises the following steps: (1) subjecting 1-amino-3-chloro-2-propanol hydrochloric acid to reacting with chlorosuccinic acid in an alkaline aqueous solution for 1 hour to prepare a solution I; (2) subjecting ethylene glycol disodium to reacting with 3,5-dichlorobenzenesulfonic acid in an alkaline aqueous solution for 0.5 h to prepare a solution II; and (3) mixing the solution I, the solution II and 3-chloro-5-epoxy methylbenzenesulfonic acid, conducting stirring and reacting for 3 hours to prepare the polyimide water-borne epoxy resin. The coating disclosed by the invention has the advantages of high chemical stability, low construction environment requirement, environment friendliness, no toxicity, high water resistance of a cured product and the like, and has prominent popularization prospects.

An environmentally friendly lipstick case formed of PET includes a cap including an internal annular groove on a bottom; a rotation tube including internal spiral guide grooves; an ascending and descending tube including two opposite guide pins on an outer surface, and longitudinal ribs on an inner surface; a support tube including two opposite longitudinal tunnels on a surface, each longitudinal tunnel having an upper horizontal end and a lower horizontal end oriented in a direction opposite to that of the upper horizontal end, and an annular toothed member on a bottom of an inner surface; and a lower exterior casing including an annular shoulder on an outer surface of an upper portion, projections between the annular shoulder and an open top, and a protrusion on a blind bottom disposed in the toothed member. The guide pins are moveably disposed through the longitudinal tunnels into the guide grooves.

The invention discloses eye anti-wrinkle gel containing a pterostilbene compound capable of self-providing a weak acid environment. The eye anti-wrinkle gel is characterized by being prepared from thefollowing main components: 2 to 10 mg / ml of pterostilbene, 30 to 60 mg / ml of rebaudioside A, 5 to 12 mg / ml of glycyrrhizic acid, and 1 to 5 mg / ml of sodium hyaluronate. The preparation method comprises the following steps: (1) fully dissolving the pterostilbene into ethanol, mixing the rebaudioside A with the glycyrrhizic acid according to a proportion, dissolving the mixture in the pterostilbene-dissolved ethanol solution, and spinning the ethanol solution till the ethanol solution is dry, thus obtaining solid powder; (2) immersing the sodium hyaluronate in water over night till the sodium hyaluronate is completely dissolved for later use; (3) adding the solid powder obtained in Step (1) into the hyaluronate solution obtained in Step (2), and stirring the solution till the solid powder is completely dissolved. The dissolvability of the pterostilbene in the gel prepared with the method is obviously improved, so that the pterostilbene can be absorbed by eye skin more easily to exert aneye protecting effect. The eye anti-wrinkle gel is easy to prepare, and the pterostilbene compound-containing eye gel is extremely high in anti-oxidization capacity, can self-provide the weak acid environment and obviously improve the state of the eye skin, and is irritant.

Disclosed is an organic electroluminescent device (organic EL device) which is improved in luminous efficiency, sufficiently secures driving stability, and has a simple configuration. The organic EL device of this invention comprises a light-emitting layer between an anode and a cathode piled one upon another on a substrate wherein the light-emitting layer contains a phosphorescent dopant and a 1,9-substituted carbazole compound as a host material. An example of the 1,9-substituted carbazole compound is represented by the following general formula (1). In formula (1), Ar is an aromatic hydrocarbon group or aromatic heterocyclic group; L is an aromatic hydrocarbon group or aromatic heterocyclic group; each of R1 to R3 is a hydrogen atom, an alkyl group, a cycloalkyl group, an aromatic hydrocarbon group, or an aromatic heterocyclic group; n is an integer of 1 to 3.

A capturing molecule having an association containing a plurality of polypeptide chains that specifically bind to different sites of a target substance, characterized in that each of the polypeptide chains has a domain having a hypervariable loop structure at a binding site binding to the target substance and an association portion for forming the association, and the polypeptide chains are associated via the association portions present in the polypeptide chains.

A flexible display panel, comprising: a first flexible substrate and a second flexible substrate cell-aligned to each other; a blue phase liquid crystal layer disposed between the first flexible substrate and the second flexible substrate and strip electrodes arranged on the second flexible substrate at a side close to the blue phase liquid crystal layer at intervals; a reflective layer disposed on the second flexible substrate at a side far away from the blue phase liquid crystal layer; and a ¼ wave plate and a polarizer successively arranged on the first flexible substrate at a side far away from the blue phase liquid crystal layer, with an included angle between a light transmitting axis of the polarizer and an optical axis of the ¼ wave plate being 45° and an included angle between each of the strip electrodes and the optical axis of the ¼ wave plate being 90°.

This invention relates to the field of recombinant antibody technology. It provides novel recombinant IgY antibody constructs for diagnostic and therapeutical applications. The bivalent antibody constructs display a heterotetrameric or homodimeric format stabilized by disulfide bonds. The constant heavy chain domains CH2-CH4 are partly or completely of avian origin, whereas the VH, VL, CL, and CH1 domains as well as the hinge region may be of avian origin or derived from any other species. The invention allows to combine the advantages of IgY antibodies with those of established mammalian monoclonal antibodies. IgY antibody constructs comprising nonglycosylated IgY constant heavy chain domains allow to reduce unwanted interactions with C-type lectins, e.g., in human sera. Furthermore, chimeric IgY antibody containing mammalian VH, VL, CL, and CH1 domains as well as a mammalian hinge region provide a higher molecular stability than IgY antibodies in acidic conditions and, thereby, are especially suited for peroral therapeutic applications.

This invention is related to granule formulations of a molecular complex comprising a volatile compound, where no adjuvant / binder is required in such granule formulations. In addition, it is surprising that use of molecular sieve destabilizes the granule formulations provided herein, thus no molecular sieve is required. Provided are methods for preparing granule formulations of a molecular complex comprising a volatile compound, and compositions comprising such granule formulations. In addition, methods of treating plant or plant parts using compositions disclosed herein are also provided.

The invention discloses a novel IL-15 fusion protein, which at least comprises (1) an IL-15R alpha polypeptide, (2) an IL-15 polypeptide variant, (3) an Fc structural domain, an Fc structural domain derivative or a functional fragment thereof, and (4) a connexon or a derivative thereof, the IL-15 polypeptide variant at least comprises a first connexon or a derivative thereof, and the first connexon or the derivative thereof is connected with a natural amino terminal and a carboxyl terminal of the IL-15 polypeptide. According to the novel IL-15 fusion protein for tumor treatment, the anti-tumor effect of IL-15 can be improved. In addition, the tumor treatment recombinant protein can be efficiently expressed and purified, a foundation is laid for industrialization of IL-15 therapeutic protein, and the tumor treatment recombinant protein has the great potential of becoming an effective immune anti-tumor therapy medicine.