91 results about "Iohexol" patented technology

Purification process of iohexol comprising the treatment of said product with 1-methoxy-2-propanol either alone or mixed with other solvents.

The invention discloses a CT imaging contrast agent and a preparation method thereof, relating to a contrast agent and providing a CT imaging contrast agent with higher chemical stability, better CT contrast effect and biocompatibility and controllable grains and a preparation method thereof. The CT imaging contrast agent contains nano gold and iohexol and is structurally characterized in that nano gold grains are cores, and the iohexol are packed on the peripheries of the nano gold grains. The preparation method comprises the following steps of: dissolving an iohexol solution in hyperpure water to prepare an iohexol solution the iohexol concentration of which is 1.2-6mg I/ml; adding a chloroauric acid solution in the iohexol solution to prepare a reaction precursor solution the chloroauric acid concentration of which is 0.2-2mM; pouring the reaction precursor solution into an agitated reactor for reaction, and cooling reaction system to the room temperature; and centrifuging the cooled system to enable the synthetized nano gold grains to be separated from the surplus iohexol in the solution and then cleaning to obtain the CT imaging contrast agent.

The invention discloses an improved method for preparing 3,5-disubstituted-2,4,6-triiodo aromatic amine represented by a formula (II), wherein R1 and R2 are defined in the instruction, and the compound represented by the formula (II) is a key intermediate for synthesizing iopamidol, iohexol, iodixanol and a series of non-ionic contrast agents. The method comprises: adopting a chlorine-free iodination reagent and a 3,5-disubstituted aromatic amine compound to carry out an iodination reaction to obtain the 3,5-disubstituted-2,4,6-triiodo aromatic amine represented by the formula (II), wherein a mole yield of the iodination reaction can be 89%.

The invention provides a preparation method for an iohexol of 5-[N-(2, 3-dihydroxypropyl)acetyl]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-3-triiodo-1,3-benzamide, belonging to a non-ionic X-CT contrast agent (organic compound) technology field. The invention improves the existing technology by protecting side-chain hydroxyl with amino-acetonide before N-alkylation so as to avoid O-alkylation at the time of N-alkylation. Positive resin/methanol-water system is used as protection system. The invention greatly reduce main impurity oxygen alkyl compound in iohexol and improve the yield.

The invention relates to a synthetic method of iohexol impurities, in particular to a synthetic method of an iohexol impurity F and an application thereof in synthesis of an iohexol impurity G, an impurity H and an impurity M and belongs to the technical field of medicines. The method comprises the steps as follows: a compound in formula 3 is prepared from raw materials including 5-nitro-1,3-dimethyl phthalate (a compound in formula 2) and 2,3-dihydroxyl propylamine, the compound in formula 3 and hydrogen are subjected to a reduction reaction to prepare a compound in formula 4, and the compound in formula 4 reacts with iodine chloride to obtain the iohexol impurity F. 5-amino-N,N'-bis(2,3-dihydroxypropyl)-diiodo-1,3-benzenedicarboxamide (a compound in formula 1) is synthesized from 5-nitro-1,3-dimethyl phthalate (the compound in formula 2) as the initial material, the impurity G, the impurity H and the impurity M are synthesized from the compound in formula 1 as the initial material, and qualified impurity reference substances are provided for quality control of iohexol.

The invention discloses a novel bimodal micromolecular contrast agent and a preparation method and application thereof. According to the contrast agent, by utilizing the characteristic that ICG can beselectively enriched in a liver cancer area and form strong contrast with surrounding tissue, a key structure of ICG is selected as a carrier to be connected with diatrizoic acid, iohexol and other functional groups of CT contrast agents rich in iodine group in order to obtain a liver cancer targeting property and enhance the penetration capacity at the same time, and correspondingly the micromolecular near-infrared/CT bimodal contrast agent is designed and synthesized. The micromolecular contrast agent has high water solubility and low toxicity, and two contrast modes are mutually verified;diagnosis information is enriched, the diagnosis precision is improved, and the feasible novel contrast agent is provided for clinical early diagnosis of liver cancer.

The invention discloses a PDI-loaded biochar photocatalyst and a preparation method and a use method thereof. The photocatalyst is prepared from the following raw material components: PDI, charcoal and acid in a mass ratio of 1 to 45: 1: 3000 to 7000. According to the invention, perylene-3, 4, 9, 10-tetracarboxylic dianhydride, beta alanine, imidazole and biochar are used as raw materials, an organic synthesis method is adopted to obtain PDI, the photocatalyst is obtained through synchronous acidification, and the application method of the photocatalyst is provided, so that the PDI-loaded biochar photocatalyst prepared by the invention is simple in preparation process and high in yield, and has good application prospects under the condition of not introducing metal elements. A system can perform efficient catalytic degradation on iohexol in water.

The invention discloses a temperature-responsive supra-molecular copolymer hydrogel embolization material and a preparation method thereof, wherein two monomers such as acrylamide and N-acryloyl chloride glycinamide are copolymerize under the action of an initiator to obtain a polymer gel PNAGA-PAAm, the polymer gel and iohexol are mixed at a high temperature to obtain a uniform mixture, the iohexol-containing hydrogel can be injected into renal artery through a microcatheter in a molten state at a temperature of slightly above the body temperature to embolize the kidney so as to be used for embolizing large arteries, the hydrogel mixture can undergo sol-gel transition at the temperature near body temperature, and the transition is fast. According to the present invention, the iohexol-containing polymer can be developed under X-rays, such that the embolization material can smoothly enter the target site, and the false embolization can be avoided.

The invention belongs to the medical field and particularly relates to a contrast media injection being suitable for MR arthrography. The injection is prepared from the following raw materials: 0.05-0.25 ml of gadopentetate dimeglumine, 1.25-5 ml of iohexol, 1.25-5 ml of lidocaine and 0-10 ml of physiological saline. The injection has following advantages: 1) under guidance of X ray or CT, the injection, when being injected into articular cavity for performing the MR inspection to the arthrosis that needs to inspect, can be used for development under both X-ray and MR inspection, wherein according to different inspection positions, only does corresponding proportion adjustment need to carry out, thus greatly simplifying operation procedure of medical staffs; 2) the injection has low permeability, low toxic and side effects, high bio-safety, low toxicity on nervous system, low generation rate of side reactions, and good body tolerance; and 3) the injection can generate high-intensive magnetic resonance signal and increase signal intensity of magnetic resonance imaging, so that an image can be displayed clearly.

The invention relates to a control and regulation device for safeguarding a conveyor device (1), in particular, a crane unit in the case of overload. A brake device (11, 18) acting on the conveyor device (1) is provided, along with a controller (30) for the brake device (11, 18), an overload sensor (29), recording the overload and emitting an overload signal and a speed sensor (31, 24), recording a cA process for the production of iohexol comprises alkylating 5-Acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6- triiodoisophthalamide using 2(2-methoxy-ethoxy)-ethanol as solvent in the presence of a base, and optionally isolating crude iohexol from the reaction mixture. Preferably, the alkylating agent is 1-chloro-2,3 propanediol and the base is an alkali metal hydroxide such as sodium hydroxide or potassium hydroxide.onveyed item speed and emitting a speed signal. The controller (30) reacts to the overload signal on the braking device (11, 18), such that this device stops the conveyor device and thus safeguards a conveyed item (16).; On a subsequent unload signal the controller (30) releases the conveyor device (1) such that the conveyor device (1) is moved into an unload position by the effect of the load of the conveyed item (16) and the effect of the braking device (11, 18) on the conveyor device (1) is regulated according to the speed signal from the speed sensor (24, 31) such that the conveyed item (16) is moved into the unload state at an essentially constant conveyor speed. The invention further relates to a conveyor device with such a control and regulation arrangement and a container crane unit with two conveyor devices provided with such a control and regulation device.

The invention provides a formula of a density gradient solution used for tissue and cell purification. According to the formula, the density gradient solution contains density gradient ingredients, such as iohexol, sodium diatrizoate and iodixanol, wherein the substances capable of improving the osmotic pressure and preventing tissue and cell edema, such as raffinose and mycose are added, then magnevist solution is also added, and culture solutions such as DMEM culture solution and buffer solutions such as HBSS buffer solution are adopted as the solvents. With the adoption of the formula, the problems that at present, the density gradient separation for tissues and cells of large animals and human beings is difficult, and the separated tissues and cells are low in activity are solved, and the cells and tissues with different densities after dissociation or mechanical dispersion can be separated by the density gradient solution under the centrifugal condition. Due to the design of the density gradient solution, a certain application value is achieved for promoting the domestic and overseas study on the separation of tissues and cells. The principle is simple, the preparation is easy, the use is convenient, and the large-scale preparation can be realized; due to the declaration of the patent, a foundation is laid for the development and application of the density gradient separating solution.

A composition and a method for clearing tissue for subsequent three-dimensional analysis. The clearing composition comprises: (1) a homogenizing agent such as N-methylglucamine, urea, or ethylenediamine; (2) a cytoplasmic, water-soluble refractive index adjusting agent such as iohexol, sodium thiosulfate, or polyethylene glycol; and (3) a membrane, lipid-soluble RI adjusting agent such as 2,2′-thiodiethanol (TDE) or propylene glycol. The tissue clearing composition is particularly suitable for use with long-term fixed human tissues.

The invention discloses an exclusive method for detecting the content of iohexol in plasma of rhesus monkeys and application thereof to evaluation of the influence of a drug on GFR (Glomerular Filtration Rate), and belongs to the field of drug evaluation. The exclusive method comprises the following steps: (1) standard product working solution and standard curve preparation: preparing standard production working solutions in various concentrations; (2) preparation of an internal standard production solution preparing an iohexol impurity I working solution; (3) sample pretreatment; (4) determination of iodexol: determining under the conditions that a C18 is used as a chromatography column, a mobile phase comprises a mobile phase A which is methanol and a mobile phase B which is phosphoric acid water, isocratic elution with elution time of 10 minutes , 20 to 40 DEG C in temperature and 0.2 to 1.5 mL/min in flowing speed, the detection wavelength of a chromatogram is 190 to 320 nm and thesampling volume is 1 to 20 mu L. The exclusive method disclosed by the invention is capable of detecting the content of the iohexol, is accurate and simple and is time-saving and labor-saving; the dosage of the iohexol required for determining and evaluating the GFR by utilizing the iodexol clearance rate is smaller, and the safety of kidney is greatly improved; the exclusive method is simple andreliable, the exclusiveness is strong, and effective experimental data can be provided for clinical application.

The invention relates to a triiodobenzene compound and a contrast medium with same and also provides a preparation method of the compound. The compound in the invention is 5-(2-hydroxylacetamido)-N-methyl-N-(2-hydroxyethyl)-N'-(2,3-dihydroxyl-n-propyl)-2,4,6-triiodoisophthalamide (I). Compared with the existing clinical nonionic contrast medium monomers such as Iohexol and Iomeprol, the contrast medium in the invention has lower osmotic pressure and viscosity.

The invention discloses a PDI/MOF heterojunction photocatalyst and a preparation method and a use method thereof. The photocatalyst is prepared from the following raw material components: PDI, MIL-101 (Cr) and acid in a mass ratio of 1: 0.11-1: 37. According to the invention, perylene-3, 4, 9, 10-tetracarboxylic dianhydride, beta-alanine, imidazole and MOF are used as raw materials, PDI is obtained by an organic synthesis method, the PDI/MOF heterojunction photocatalyst is obtained by a water bath heating method, and the use method of the photocatalyst is provided, so that the prepared PDI/MOF photocatalyst has the characteristics of simple preparation process, high yield, large specific surface area and multiple reaction sites; and the use of hydrofluoric acid is avoided, and the material can activate persulfate under visible light to perform efficient catalytic degradation on iohexol in water.

The invention belongs to the technical field of imaging methods, and discloses a nano contrast agent and a preparation method thereof. The preparation method of the nano contrast agent comprises the following steps of synthesizing blue tungsten oxide nano particles with particle size of 60nm by using a hydrothermal method, and dispersing the nano particles in water uniformly, so as to synthesize suspension liquid; preparing a series of iodine and tungsten solutions of different concentrations by using iohexol and tungsten oxide nano particles, and detecting and imaging by using CT. The methoddiscloses the targetability of WO3-X at PEG-Tf, compares the difference of normal cells and cancer cells in endocytosis of targeted tungsten oxide nano particles and in vivo distribution of tumor-bearing rats and rats, gives an explanation that the WO3-X at PEG-Tf can be identified specifically and highly by cancer cells (the cancer cells have rich Tf receptors on the surface), argues the advantage of covalent modification of transferrin, and discloses SPECT/CT imaging and biocompatibility of the WO3-X at PEG-Tf.

The invention discloses a synthesis method of iohexol, which comprises the following steps: taking a compound (I) as a raw material, carrying out amidation reaction to obtain a compound (II), then carrying out alkylation reaction on the compound (II) and glycidol under the catalytic action of organic alkali to obtain a compound (VIII), and finally carrying out hydrolysis or alcoholysis deacetylation protection to obtain a target compound (IV). The reaction formula is shown in the specification. The reaction route can effectively avoid generation of byproducts.