67 results about "Iodixanol" patented technology

The invention relates to a composite developing thermosensitive gel embolizing agent as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, preparing a mixed aqueous solution of an anticancer active substance, a thermosensitive material and a developing agent into composite developing thermosensitive gel; secondly, forming a composite developing thermosensitive gel embolizing agent by the composite developing thermosensitive gel and a coagulant on the scene, wherein the thermosensitive material is hydroxyl C1-4 alkyl cellulose, Pluronic, alginate or a mixture of the substances; the anticancer active substance is arsenic trioxide, docetaxel, cisplatin, carboplatin, nedaplatin, oxaliplatin, lobaplatin, miriplatin, siRNA or a mixture of the substances; the developing agent is a water-soluble developing agent of iodixanol, ioversol or iohexol and the like. The preparation method disclosed by the invention is simple and convenient, is suitable for industrial large-scale production, is particularly suitable for preparing an embolizing agent which is biodegradable and good in biocompatibility and is used for hemorrhagic diseases, and is especially suitable for preparing the composite developing thermosensitive gel embolizing agent for treating liver cancer, kidney cancer, lung cancer, prostate cancer, uterine myoma or splenic tumor and the like.

The invention discloses an improved method for preparing 3,5-disubstituted-2,4,6-triiodo aromatic amine represented by a formula (II), wherein R1 and R2 are defined in the instruction, and the compound represented by the formula (II) is a key intermediate for synthesizing iopamidol, iohexol, iodixanol and a series of non-ionic contrast agents. The method comprises: adopting a chlorine-free iodination reagent and a 3,5-disubstituted aromatic amine compound to carry out an iodination reaction to obtain the 3,5-disubstituted-2,4,6-triiodo aromatic amine represented by the formula (II), wherein a mole yield of the iodination reaction can be 89%.

The invention provides an improved synthesis method of iodixanol and macroporous adsorbent resin chromatography column purification and solvent recrystallization purification processes which are easy to be used for industrialization. In the synthesis method, iodixanol is synthesized by dimerisation of 5-acetamido-N, N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide ('Compound A'), wherein hydroxyacid containing boron or borate and the like are used to form a buffer solution for controlling the pH value of a reaction process, thus side reactions such as excessive alkylation and the like are effectively inhibited and the transformation ratio for transforming into the iodixanol is improved, the crude product containing 85-90% of iodixanol is obtained and then is purified by a macroporous adsorbent resin chromatography column, the total recovery of the iodixanol is 90-95%, the purity of the iodixanol is more than 97%; and the iodixanol is subjected to recrystallization in a solvent containing 2-methoxy ethanol, the recovery of the iodixanol is 90-95%, and the purity of the iodixanol is more than 99%.

The invention relates to a fluorescent-CT bimodal imaging probe and a preparation method thereof, specifically relates to a fluorescent-CT bimodal iodine doped carbon quantum dot prepared by a one-step hydrothermal carbonization method and application of the fluorescent-CT bimodal iodine doped carbon quantum dot in biomedical images, and belongs to the field of biomedical materials. The specific scheme is as follows: dissolving iodixanol and glycine in an aqueous solution according to a certain mass ratio to serve as precursors, putting the solution in a hydrothermal reaction kettle with polytetrafluoroethylene lining, heating up to 120-200 DEG C to react for 4 hours, dialyzing and freeze drying nigger-brown reaction liquid to remove residues and water to obtain black powdery nanoparticles, namely iodine doped carbon quantum dots. The iodine doped carbon quantum dot prepared by the method has such excellent properties as stable fluorescence, efficient X-ray attenuation capacity and good biocompatibility, and is successfully applied to live cell fluorescent imaging in vitro and CT imaging in vivo. The method has the advantages of simple operation, environmental protection and easy mass production.

The invention relates to a method for separating and purifying iodixanol injection raw materials by macroporous resin. The method comprises the following steps: dissolving and synthetizing the iodixanol raw materials with water, carrying out adsorption separation and purification with PIPO-02 macroporous resin, adopting a non-linear chromatography method to perform pressing continuous chromatography, carrying out segmentation elution with ethanol, activating and recycling parting materials. The process flow is simple, the cost is low, the efficiency is high, the environment is protected, posts can be subjected to on-line activation and recycle, and the method is suitable for producing iodixanol products for injection industrially. PIPO-02 macroporous resin has remarkable advantages as compared with C-18 separating material, the cost of PIPO-02 macroporous resin is only about 20% of C-18 reverse phase silica gel, the adsorption capacity of PIPO-02 macroporous resin is about 2.5 times of C-18 separating material, the non-linear chromatography method is adopted to produce 98% iodixanol products for injection to the maximum limit, and the 98% iodixanol products have obvious advantages.

The invention discloses iodixanol and a preparation method of a synthetic intermediate 1, 3-bi (acetamino)-N, N'-bi [3, 5-bi (chloroformyl)-2, 4, 6-triiodo-phenyl]-2-propanol acetate of iodixanol. A dimerization condensation reaction of 5-acetamino-N, N'-bi (2, 3-dihydroxy propyl)-2, 4, 6-triiodo-isophthalamide as a final step is avoided by the preparation method, so that the content of iodixanol in a product is effectively improved, the purity of the obtained iodixanol crude product is greater than 90%, and the highest content of single impurity is less than 2%, so that the difficulty of purifying the product is reduced.

Alternative continuous downstream processes for the production of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”) are described. Compound A is a key intermediate in the production of iodixanol and iohexol, which are two of the biggest commercially available non-ionic x-ray contrast media agents.

An improved synthesis method for preparation of iodixanol, and a purification process through macroporous adsorption resin chromatographic column and recrystallization are provided. The synthesis method relates to dimerization of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide (compound A) to prepare iodixanol, wherein excessive side reactions such as alkylation are effectively inhibited by controlling the pH of the reaction mixture with a boron-containing acidic substance or salts thereof such as boric acid. In this way, the conversion rate of compound A to iodixanol is 85-90%. The iodixanol crude product is purified by a macroporous adsorption resin chromatographic column, obtaining iodixanol product with recovery of 90-95% and purity of 96-98%. The iodixanol crude product is recrystallized in mixed solvent containing 2-methoxyethanol, obtaining iodixanol product with recovery of 90-95% and purity of greater than 99%.

A process for the manufacture of iodixanol by performing a crystallization process of the crude product in a solvent mixture comprising water, methanol and isopropanol. The crude product may be obtained in aqueous solution from dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide (“Compound A”).

The invention belongs to the technical field of medicine preparations, and discloses iodixanol injection and a method for preparing the same. The iodixanol injection comprises iodixanol, sodium chloride and sodium sulphate. The method includes adding the balance water for injection into the iodixanol, the sodium chloride and the sodium sulphate to obtain mixed liquid; regulating the mixed liquid by the aid of acid until the pH (potential of hydrogen) of the mixed liquid is within an appropriate pH range. Compared with the prior art, the iodixanol injection and the method have the advantages that the types and the quantities of excipients added into the iodixanol injection are greatly reduced, the viscosity of the injection is further lowered, and accordingly the application compliance of clinical patients can be improved; as studied via high-temperature sterilization testes, low-temperature freezing and thawing experiments, irritation tests and the like, the iodixanol injection is stable in quality and low in vascular irritation, and requirements on safe medication can be completely met.