Temperature-responsive supra-molecular copolymer hydrogel embolization material and preparation method thereof

Abstract

The invention discloses a temperature-responsive supra-molecular copolymer hydrogel embolization material and a preparation method thereof, wherein two monomers such as acrylamide and N-acryloyl chloride glycinamide are copolymerize under the action of an initiator to obtain a polymer gel PNAGA-PAAm, the polymer gel and iohexol are mixed at a high temperature to obtain a uniform mixture, the iohexol-containing hydrogel can be injected into renal artery through a microcatheter in a molten state at a temperature of slightly above the body temperature to embolize the kidney so as to be used for embolizing large arteries, the hydrogel mixture can undergo sol-gel transition at the temperature near body temperature, and the transition is fast. According to the present invention, the iohexol-containing polymer can be developed under X-rays, such that the embolization material can smoothly enter the target site, and the false embolization can be avoided.

Description

technical field [0001] The invention belongs to the preparation technology of vascular embolic materials in the field of biomedical engineering, and more specifically relates to a temperature-responsive supramolecular copolymer hydrogel embolic material and its preparation method and application. Background technique [0002] Transcatheter arterial embolization, as an auxiliary method of surgical operation, has played an increasingly important role in clinical medicine. Transcatheter arterial embolization (TAE) is widely used in the treatment of arteriovenous malformations, unresectable tumors, and intracranial aneurysms. Compared with traditional surgical resection, TAE has the advantages of low risk, high success rate, mild treatment process, and low complication rate. Briefly introduce transcatheter arterial embolization. The embolic agent is injected into the designated location through a microcatheter. The entire injection process is accurately carried out under the mo...

AI Technical Summary

Problems solved by technology

However, the existing embolic agents still have many disadvantages in clinical application. Many embolic agents need to use toxic organic solvents in the production process, while the embolic agents based on aqueous solutions are easy to adhere to catheters, and monomers are harmful. Disadvantages such as toxicity and difficulty in application

For example, polyvinyl alcohol is a permanent granular embolic agent. Although the injection process is simple, controllable, and time-limited, due to its granular nature, the embolization is incomplete, causing the recanalization of the embolized blood vessels. , so that the operation fails, and it is prone to misembolization; Onyx, as a liquid embolic agent, has good dispersion and is widely used clinically, but it uses dimethyl sulfoxide (DMSO) as a solvent, and DMSO has no effect on Because the catheter has a certain degree of corrosion, and studies have shown that DMSO has strong vascular toxicity, which can cause acute vasospasm, injury and necrosis

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