The invention provides a preparation method of an aromatic
nitrogen heterocyclic compound. According to the preparation method, a compound represented by formula I, and a
nitrogen-containing
heterocyclic compound are subjected to illumination reaction in the presence of a photocatalyst, an organic
phosphoric acid, and a
solvent so as to obtain a compound with a structure represented by formula II, wherein
electron transition of the photocatalyst is excited by illumination so as to catalyze
decarboxylation of active carboxylic esters in the compound with the structure represented by formula I, and minisci reaction with the
nitrogen-containing
heterocyclic compound is realized so as to introduce nitrogen heterocyclic rings. Compared with a reported conventional method wherein nitrogen heterocyclic rings are introduced via minisci reaction, the preparation method comprises following steps:
equivalent weight strong oxidant application is avoided; the universality of substrate range and functional group compatibility is increased; the preparation method can be applied in
gram-grade scale reaction of
decarboxylation and nitrogen heterocyclic ring introduction of active carboxylic esters of polypeptides, and
decarboxylation and nitrogen heterocyclic ring introduction of active carboxylic esters of amino acids; conversion rate is high; and industrial synthesis value prospect is promising.