45 results about "Ether formation" patented technology

The invention discloses a preparation method and applications of an oriented immobilized PEGA composite resin. The preparation method comprises following steps: 2-amino-6-chloropurine and 4-nitrobenzyl alcohol are taken as raw materials for Williamson ether synthesis so as to obtain 4-nitryl-O6-benzylguanine; 4-nitryl- O6-benzylguanine is subjected to reduction reaction with protection of t-butyloxycarboryl; coupling reaction of an obtained compound with gamma-aminobutyric acid protected by carbobenzoxy chloride is carried out in the presence of ethyl dimethyl carbodiimide and 1-hydroxybenzotriazole; O<6>-benzylguanine derivative modified PEGA resin is obtained via reduction, separation and purification, reaction with PEGA, and deprotection; and transalkylation reaction of the O<6>-benzylguanine derivative modified PEGA resin with a protein containing MGMT label is carried out, so that oriented immobilization on PEGA resin surface via thioether covalent bonds is realized. Reaction of the preparation method is stable; the steps are simple; a stable uniform protein coating with uniform orientation can be formed on solid material surface by a prepared product; and the preparation method is used for preparing reagent kit with specific recognition effects.

A preparation method of a compound of formula I is characterized in that the compound of formula I is obtained through one step direct condensation ether formation on a raw material of formula II and a raw material of formula III. The protection of reactive hydrogen on the nitrogen atom of the compound of the formula III is not needed in the invention, and a sulfonic acid compound is adopted as a reaction assistant, so the side reaction is reduced, reaction steps are simplified, and a satisfactory product yield can be realized. The compound of formula I having a single optical isomer can be obtained when the raw material of formula II having different isomers is selected.

A delivery system for an active substance, comprising a substrate on which the substance is loaded for subsequent release, wherein: (i) the substrate has been at least partially coated with a polymer using plasma deposition (preferably pulsed plasma deposition); (ii) the active substance is present as a guest molecule within a cyclodextrin inclusion complex; and (iii) the inclusion complex is bound to the polymer through a chemical linkage formed between a hydroxyl group on the cyclodextrin and a functional group on the polymer. The system may be used to control the release of an active substance such as a perfume. Also provided are methods for preparing (a) the delivery system and (b) a functionalised substrate for use as part of the system, in which the polymer is suitably reacted with a cyclodextrin using an S N 2 nucleophilic substitution reaction, in particular a Williamson ether synthesis reaction.

The invention discloses a method for preparing 16,17-dialkoxyviolanthrone derivatives. A readily available 16,17-dimethoxyviolanthrone dye is used as an initial raw material, a 16,17-dihydroxyviolanthrone intermediate is prepared through demethylation, and the corresponding 16,17-dialkoxyviolanthrone derivatives are synthesized through Williamson ether synthesis reaction. The method has the characteristics of short whole reaction route, high yield, mild reaction conditions and low cost.

The present invention relates to hydrogenation catalysts prepared from polyoxometalate precursors. The polyoxometalate precursors introduce a support modifier to the catalyst. The catalysts are used for hydrogenating alkanoic acids and/or esters thereof to alcohols with relatively low ether formation, preferably with conversion of the ester coproduct. The catalyst may also comprise one or more active metals.

The invention relates to a synthesis method of abiraterone. The synthesis method comprises the following steps of with dehydroepiandrosterone as a raw material, carrying out ether formation protection on hydroxyl by using a protecting group to obtain a compound; next, subjecting the compound, 3-bromopyridine and a Grignard reagent to reaction to obtain 3 beta-substituted oxo-17-(3-pyridyl)-androst-5-ene-17-ol; and heating the 3 beta-substituted oxo-17-(3-pyridyl)-androst-5-ene-17-ol, acid or a dehydrant and the like in an organic solvent, dehydrating, and then, removing the protecting group of the hydroxyl to obtain the abiraterone. The method provided by the invention has the advantages of simplicity and easiness in operation, adoption of low-toxicity raw materials and particular suitability for industrial production.

The invention discloses a preparation method of 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g] quinoline-2,8-sodium dicarboxylic acid (Nedocromil sodium). A raw material of m-anisidine (a compound A ) is treated with a condensation reaction to generate a compound B; the compound B is treated with a first Friedel-Crafts acylation to obtain a compound C1 and a compound C2; the compound C1 and the compound C2 are treated with demethylation, and isomer C2 is separated out to obtain a compound D; the compound D is treated with a second Friedel-Crafts acylation to obtain a diacetyl compound E; and the compound E is treated with a substitution reaction, ether formation, rearrangement, reduction, ring formation, hydrolysis and salt forming reaction to obtain the Nedocromil sodium (a compound L). The method of the invention increase synthesis yield of Nedocromil sodium.

The invention discloses a photo-responsive quaternary cationic surfactant capable of forming a wormlike micelle and a synthetic method thereof. The surfactant has a structural formula as shown in the specification. In the formula, R represents a straight-chain alkyl group. The photo-responsive quaternary cationic surfactant is prepared from p-hydroxyazobenzaldehyde, 1,2-dibromoethane and N,N-dimethylalkylamine through a reduction reaction, a Williamson ether synthesis reaction and a quaterization reaction. The synthetic method provided by the invention is simple to operate and uses cheap and easily available raw materials; the synthesized surfactant has high purity and a yield of more than 64.0%; an aqueous solution of the synthesized surfactant has good photo-responsiveness and low surface tension; critical micelle concentration is lower than 4.0*10<-4> mol/L; and the synthesized surfactant can form the wormlike micelle.

The invention belongs to the technical field of medicines, and discloses a 2,2-dimethylbenzopyran derivative and a preparation method and use of the 2,2-dimethylbenzopyran derivative. The derivative and pharmaceutically acceptable salt of the derivative have the structural formulae shown in the description, wherein Ar<1>, Ar<2>, X, Y and R1 are as described in the claims and the description. The preparation methods of the derivative and the pharmaceutically acceptable salt of the derivative comprise the following steps: the formula (I) is obtained by mainly taking acetaminophen as a raw material, and subjected to the reactions of Williamson ether formation, cyclization, hydrolysis, amide formation and the like; the formula II is obtained by mainly taking p-hydroxybenzaldehyde as a raw material, and subjected to the reactions of the Williamson ether formation, cyclization, Knoevenagel condensation, amide formation and the like. The derivative and the pharmaceutically acceptable salt ofthe derivative disclosed by the invention can be used for preparing neuroprotective agents and have better neuroprotective effects on ischemic stroke.

The invention discloses 3-azidomethyl-3-methyloxetane-tetrahydrofuran energetic copolyether with an alternating multi-block structure and a synthesis method thereof. The structural formula of the alternating multi-block energetic adhesive is shown as (I) in the specification, wherein m is equal to 1-5, n is equal to 1-4, k is equal to 1-10, and m, n and k are integers. The synthesis process comprises the following step of: by taking polytetrahydrofuran (PTHF) and a 3-azidomethyl-3-methyloxetane homopolymer (PAMMO) as raw materials and KOH as a catalyst, carrying out a Williamson ether synthesis method to obtain the alternate multi-block azido energetic adhesive. The synthesis method is simple, and the alternating multi-block AMMO-THF energetic adhesive has an adjustable microscopic sequence structure and can endow a material with relatively good mechanical properties and processability.

The invention discloses 3, 3-diazido methyl oxetane-ethylene glycol energetic copolyether with an alternating multi-block structure and a synthesis method thereof, the structural formula of an alternating multi-block energetic adhesive is shown as (I), m is equal to 1-4, n is equal to 1-4, l is equal to 1-4, k is equal to 1-10 and is an integer. The synthesis process comprises the following steps: by taking polyethylene glycol (PEG) and a 3, 3-diazido methyl oxetane homopolymer (PBAMO) as raw materials, carrying out Williamson ether synthesis to obtain the alternate multi-block azido energetic copolyether. The synthesis method is simple, and the alternating multi-block BAMO-EG energetic copolyether has an adjustable microscopic sequence structure and can endow a propellant with relatively good mechanical properties.

The invention relates to a preparation method of a multi-target anti-tumor drug. The method comprises the following steps: 1, nitrogen protection: by using a williamson ether synthesis method, using 4-amino-3-fluorophenol and 4-chlorine-2-pyridine carboxamide as raw materials and dimethyl sulfoxide and tetrahydrofuran as a mixed solvent under the effect of potassium tert-butoxide to generate 2-carbamoyl-4-((3-fluorine-4-amino) phenoxy) pyridine by reaction; and 2, reacting the 2-carbamoyl-4-((3-fluorine-4-amino) phenoxy) pyridine with 4-chlorine-3-(trifluoromethyl) benzene isocyanate in a dioxane solvent to obtain a crude product, and refining the crude product to obtain a final product 4-{4-[3-(4-chlorine-3-trifluoromethyl-phenyl)urea]-3-fluorine phenoxy} pyridine-2-formamide.

The invention discloses maleate monomers used for preparing pour depressant components and a preparation method of the maleate monomers. The maleate monomers are structurally characterized by being maleate alkoxy alcohol ester. The preparation method comprises the steps that n-alcohol and n-alkane with the terminal substituted with dichloro are used as raw materials, chloroether with the total number of carbon of 20-26 is synthesized through the Williamson ether synthesis method, and then the chloroether and sodium maleate are subjected to the SN2 reaction to synthesize maleate. The preparation method of the maleate monomers is simple, the raw materials are easy to obtain, the product yield is high, and many kinds of maleate monomers can be prepared.