A kind of thiazolotriazole superoxide dismutase agonist and its preparation method and application

A technology of superoxide and triazole, applied in the direction of anti-toxic agent, anti-inflammatory agent, organic chemistry, etc., can solve problems such as tissue damage

Active Publication Date: 2021-07-23
九吉兴(北京)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

That is to say, most tumor treatment methods can induce tumor cell apoptosis while also causing damage to normal tissues in the body, especially tissues with high cell proliferation rate or the main pathway of drug metabolism.

Method used

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  • A kind of thiazolotriazole superoxide dismutase agonist and its preparation method and application
  • A kind of thiazolotriazole superoxide dismutase agonist and its preparation method and application
  • A kind of thiazolotriazole superoxide dismutase agonist and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022]

[0023] In the reaction flask, add 9g of formamide and 9g of thiosemicarbazide to 50mL of dimethyl sulfoxide, then add 1.8g of kaolinite particles; slowly raise the temperature to 90°C, filter the reaction solution while it is hot after the reaction, and then put Pour the reaction solution into 100mL of water, extract with 50mL of dichloromethane for several times, combine the organic phases, concentrate and then add 50mL of methanol, slowly raise the temperature to 60°C and then slowly cool down to 0°C. Obtained amine formaldehyde condensate 4g; Anal.Calcd forC 2 h 6 N 4 S: C, 20.33; H, 5.12; N, 47.42. Found: C, 20.57; H, 5.03; N, 47.19.

Embodiment 2

[0025]

[0026] In the reaction flask, add 9g of formamide and 9g of thiosemicarbazide to 50mL of dimethyl sulfoxide, then add 1.8g of hydromica particles; slowly raise the temperature to 90°C, filter the reaction solution while it is hot after the reaction, and then put Pour the reaction solution into 100mL of water, extract with 50mL of dichloromethane for several times, combine the organic phases, concentrate and then add 50mL of methanol, slowly raise the temperature to 60°C and then slowly cool down to 0°C. Obtain amine formaldehyde condensate 6g; Anal.Calcd forC 2 h 6 N 4S: C, 20.33; H, 5.12; N, 47.42. Found: C, 20.57; H, 5.03; N, 47.19.

Embodiment 3

[0028]

[0029] In the reaction bottle, add 9g of formamide and 9g of thiosemicarbazide to 50mL of dimethyl sulfoxide, then add 1.8g of montmorillonite particles; slowly raise the temperature to 90°C, filter the reaction solution while it is hot after the reaction, and then put Pour the reaction solution into 100mL of water, extract with 50mL of dichloromethane for several times, combine the organic phases, concentrate and then add 50mL of methanol, slowly raise the temperature to 60°C and then slowly cool down to 0°C. Obtained amine formaldehyde condensate urea 10g; Anal.Calcd forC 2 h 6 N 4 S: C, 20.33; H, 5.12; N, 47.42. Found: C, 20.57; H, 5.03; N, 47.19.

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PUM

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Abstract

The invention discloses a thiazolotriazole superoxide dismutase agonist, a preparation method and application thereof, and belongs to the technical field of synthesis of protease agonists. The gist of the technical solution of the present invention is as follows: the thiazolotriazole superoxide dismutase agonist has the structure of Intramolecular ring formation, chlorination, ester formation, ester hydrolysis, ether formation and other multi-step reactions obtain novel thiazolotriazole molecules. The invention is simple and quick to operate, has high yield, is suitable for large-scale industrial production, and the thiazolotriazole molecules can effectively improve the activity of SOD in cosmetics, and have the potential to become auxiliary additives for cosmetics.

Description

technical field [0001] The invention belongs to the technical field of protease agonist synthesis, and in particular relates to a thiazolotriazole superoxide dismutase agonist and its preparation method and application. Background technique [0002] Superoxide dismutase is an important substance in the intracellular elimination system, and its activity level can effectively reflect the antioxidant capacity of the body's cells. Studies have shown that the aging, disease and radiation damage of the body are all related to free radicals (including O 2- ) formation is related to damage, and free radicals maintain important physiological functions in the metabolic process of normal organisms. Therefore, SOD has the functions of anti-aging, anti-radiation, anti-inflammation, anti-autoimmune diseases, and inhibition of tumors and cancers, and is closely related to stomach diseases, Parkinson's syndrome, Alzheimer's disease, and cardiovascular diseases. [0003] For most malignant...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D513/04A61P39/06A61P29/00A61P37/00A61P35/00A61P1/00A61P25/16A61P25/28A61P9/00A61P17/00A61P17/02A61P17/10
Inventor 王慧芳杨维晓侯延生王春光任保齐
Owner 九吉兴(北京)生物科技有限公司
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