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41 results about "Difficult swallowing" patented technology

Difficulty with swallowing is the feeling that food or liquid is stuck in the throat or at any point before the food enters the stomach. This problem is also called dysphagia.

Thickening composition improved in viscosity development

A thickening composition characterized by containing xanthan gum having per 100 parts by weight thereof, 0.5 part by weight or more of metal salt bound on the surface of xanthan gum powder. This thickening composition is capable of convenient viscosity development by addition to water-containing objects. Thus, the thickening composition is suitable for use in, for example, food application for convenient thickening of soft drink, basting, sauce, dressing, soup, mousse, jelly, etc., or application for viscosity development by addition of a small amount thereof to meals for patients having difficulty in mastication / swallowing due to eating disorder, etc.
Owner:TAIYO KAGAKU CO LTD

Balsam pear nutrient effervescence tablet and manufacture method thereof

InactiveCN101455337AChange hard to swallowPromote absorptionFood preparationDifficult swallowingVitamin C
The present invention relates to a bitter melon product, as well as a manufacturing technique of bitter melon nourishing effervescence tablet. The bitter melon nourishing effervescence tablet takes the bitter melon extract as its main components, and the effervescing agent is formed by mixing alkaline granules and acidic granules, wherein, the alkaline granules are produced by bitter melon extract, sodium carbonate, lactose, glucose, and sweeteners; and the acidic particles granules are produced by bitter melon extract, vitamin C, citric acid, and glucose. The inventive bitter melon nourishing effervescence tablet adopts acid-base reaction to rapidly disintegrate tablets into aqueous solution, so that it not only changes the difficult swallowing in the taking process, but also improves the taste, thereby enhancing the absorption of nutrients in the process of enjoying the drinks.
Owner:刘洪生 +1

Orally disintegrating tablet of 5-HT receptor agonist and preparation method thereof

An orally disintegrating tablet of 5-HT receptor agonist and a preparation method thereof are disclosed. The invention relates to an orally disintegrating tablet of 5-HT receptor agonist as well as a prescription and a process for preparing the orally disintegrating tablet of 5-HT receptor agonist by a freeze-drying method. The orally disintegrating tablet of 5-HT receptor agonist disclosed by the invention is prepared from main medicines and pharmaceutical excipients, without the need of water while administration, capable of being rapidly disintegrated in mouth, and suitable for the administration of patients with difficulty in swallowing, such as the old and children; simultaneously, the orally disintegrating tablet of 5-HT receptor agonist is suitable for administration in a condition that water is not easy to obtain during travelling; and the orally disintegrating tablet of 5-HT receptor agonist has the advantages of being convenient to take, fast in absorption, small in first pass effect, small in irritation on digestive tract mucosa and the like, as well as has wide market application prospect. Moreover, the orally disintegrating tablet of 5-HT receptor agonist disclosed by the invention can obviously reduce the side effects of 5-HT receptor agonist. Additionally, the invention further relates to a preparation method for the orally disintegrating tablet of 5-HT receptor agonist.
Owner:BEIJING QUANTUM HI TECH PHARMA TECHCO

Enteric dry suspension of rabeprazole and dextroisomer thereof, and preparation method thereof

The invention discloses an enteric dry suspension of rabeprazole and dextroisomer thereof, and a preparation method thereof, and belongs to the technical field of medicines. The enteric dry suspension is composed of 30-59% by weight of rabeprazole enteric microspheres, 40-69% by weight of a corrective agent and 1-30% by weight of a suspending aid. Sustained-release microspheres A are prepared by a rabeprazole salt and a sustained-release skeleton material through a hot-melt spray method; the sustained-release microspheres A are coated by an isolation coating layer and an enteric coating layer in sequence; and then the sustained-release microspheres A are mixed with the corrective agent and the suspending aid. The prepared enteric dry suspension of rabeprazole and dextroisomer thereof is dispersed uniformly in intestinal tracts, and does not produce burst release. Compared with tablets or capsules, the enteric dry suspension has good stability, is convenient to separate dosage, is taken by adding water to form a solution, is good in absorptive capacity, fast in efficacy and good in bioavailability, has a good taste, is particularly suitable for patients suffering from difficult swallowing, especially for infant patients, and increases compliance of the patients. Besides, the preparation method is simple and is suitable for large-scale production and application.
Owner:河南省健康伟业生物医药研究股份有限公司

Irbesartan self-emulsifying soft capsule and preparation method thereof

The invention belongs to the technical field of medicinal preparations, and concretely relates to an irbesartan self-emulsifying solution. The irbesartan self-emulsifying solution comprises 20-40 wt% of irbesartan, 25-50 wt% of an oil phase, 10-50 wt% of an emulsifier and 5-20 wt% of a co-emulsifier. The invention also discloses a preparation method of an irbesartan self-emulsifying soft capsule. The preparation method comprises the following steps: synthesizing the irbesartan self-emulsifying solution from the irbesartan, the emulsifier, the co-emulsifier and the oil phase according to a certain ratio, and processing the self-emulsifying solution through a device to prepare the soft capsule. The above medicine is dissolved in the oil phase, the obtained solution is orally taken and then self-emulsifies in bodies to form a micro-emulsion with the particle size of about 200 nm, so the in-vitro dissolubility and the in-vivo absorption of the irbesartan are remarkably improved, and the in-vivo bioavailability is improved. The medicine can be taken at an integral grain after being processed to prepare the soft capsule, and the content of the soft capsule also can be taken out and is diluted with water to form a solution to be sent in order to improve the medicine taking compliance of old people and difficult swallowing patients.
Owner:ZHENGZHOU TAIFENG PHARMA CO LTD

Easy-to-administrate oxiracetam granular formulation and preparation method

The invention relates to an easy-to-take oxiracetam particle preparation and a preparation method, which pertains to the technical field of medicine and is used for solving the problems of stability and inconvenient administration. The preparation comprises oxiracetam nano-particles and pharmaceutical excipients, the mix ratio by weight units of the main drug oxiracetam and the pharmaceutical excipients after the improvement is 1.195: 1, the pharmaceutical excipients are composed of mannitol, asipatan, sunset yellow and powdered fragrances, and the mix ratio by weight units of the ingredientsof the pharmaceutical excipients is 440: 5: 0.2: 1. The selection of the excipients in a formula of the preparation of the invention, the mix ratio of the main drug and the excipients and the mix ratio relationship among the excipients are accurate and reasonable, thus being characterized by easy water solubility, better smell and convenient administration, more particularly, the administration by the patients with difficult swallow of other oral preparations or the patients with senile dementia who are not cooperative for injection drug delivery. The preparation has stable quality and easy preservation, thus being applicable to the patients for long-term administration. The oxiracetam particle preparation of the invention has simple preparation process, lower production cost and easy implementation.
Owner:CSPC OUYI PHARM CO LTD

Composition as well as preparation method and application thereof

The invention provides a dextromethorphan quinidine composition as well as a preparation method and application of the dextromethorphan quinidine composition. According to the dextromethorphan and quinidine composition provided by the invention, the bitter taste and the numb taste of dextromethorphan and quinidine are improved by adding cyclodextrin, meanwhile, the dextromethorphan and quinidine composition provided by the invention is easily prepared into various oral preparations easy to swallow, the problem that patients with nervous system diseases are difficult to swallow is solved, and the medication experience can be greatly improved.
Owner:北京剂泰医药科技有限公司 +1

A kind of enteric-coated dry suspension of rabeprazole and its dextrorotatory isomer and preparation method thereof

The invention discloses an enteric dry suspension of rabeprazole and dextroisomer thereof, and a preparation method thereof, and belongs to the technical field of medicines. The enteric dry suspension is composed of 30-59% by weight of rabeprazole enteric microspheres, 40-69% by weight of a corrective agent and 1-30% by weight of a suspending aid. Sustained-release microspheres A are prepared by a rabeprazole salt and a sustained-release skeleton material through a hot-melt spray method; the sustained-release microspheres A are coated by an isolation coating layer and an enteric coating layer in sequence; and then the sustained-release microspheres A are mixed with the corrective agent and the suspending aid. The prepared enteric dry suspension of rabeprazole and dextroisomer thereof is dispersed uniformly in intestinal tracts, and does not produce burst release. Compared with tablets or capsules, the enteric dry suspension has good stability, is convenient to separate dosage, is taken by adding water to form a solution, is good in absorptive capacity, fast in efficacy and good in bioavailability, has a good taste, is particularly suitable for patients suffering from difficult swallowing, especially for infant patients, and increases compliance of the patients. Besides, the preparation method is simple and is suitable for large-scale production and application.
Owner:河南省健康伟业生物医药研究股份有限公司
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