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Methylsulfonic acid pridinol oral disintegrating tablet and preparation method thereof

A technology of orally disintegrating tablets and pridinol, which is applied to the orally disintegrating tablets of pridinol mesylate. Report and other issues, to achieve the effect of good medication compliance, simple production process, and good taste

Inactive Publication Date: 2010-03-10
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, making pridinol mesylate into orally disintegrating tablets has important clinical significance and good market prospects, but so far, there has been no research report on pridinol mesylate orally disintegrating tablets

Method used

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  • Methylsulfonic acid pridinol oral disintegrating tablet and preparation method thereof
  • Methylsulfonic acid pridinol oral disintegrating tablet and preparation method thereof
  • Methylsulfonic acid pridinol oral disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] prescription

[0049]

[0050] method Grind all the components in the prescription into fine powders with a fineness of more than 100 meshes; add 4 g of pritinol mesylate, 61 g of mannitol, 10 g of microcrystalline cellulose, and 2.5 g of crospovidone by equal volume addition method , 7 g of citric acid and 1 g of lemon essence are mixed evenly, adding a mass fraction of 4% povidone K30 solution to make a soft material, granulating with a 24-mesh sieve, drying at 60 ° C, and sizing the dry granules through a 24-mesh sieve; Add 2.5g of crospovidone, 6g of sodium bicarbonate, 1g of magnesium stearate and 1g of micropowder silica gel to the granules, mix well, and press into tablets to make 1000 orally disintegrating tablets of pridinol mesylate, each Contains pridinol mesylate 4mg.

[0051] quality The obtained orally disintegrating tablet has a smooth and beautiful surface; it completely disintegrates in 33 seconds in water at 37±1°C and passes through a 30-...

Embodiment 2

[0053] prescription

[0054]

[0055] method All the components in the prescription were crushed into fine powders with a fineness above 100 meshes; 4 g of pritinol mesylate, 51 g of mannitol, 10 g of microcrystalline cellulose, 5 g of crospovidone, Mix 10 g of citric acid and 1 g of lemon essence, add povidone K30 solution with a mass fraction of 4% to make a soft material, granulate with a 24-mesh sieve, dry at 60 ° C, and pass the dry granules through a 24-mesh sieve for granulation; Add 5g of crospovidone, 8g of sodium bicarbonate, 1g of magnesium stearate and 1g of micropowder silica gel, mix well, and press into tablets to make 1000 orally disintegrating tablets of pridinol mesylate, each containing formazan Pridinol sulfonate 4 mg.

[0056] quality The obtained orally disintegrating tablet has a smooth and beautiful surface; it completely disintegrates in water at 37±1°C within 29 seconds and passes through a 30-mesh sieve; its hardness is 20-45 Newtons; it...

Embodiment 3

[0058] prescription

[0059]

[0060] method Grind all the components in the prescription into fine powders with a fineness of more than 100 mesh; add 4 g of pritinol mesylate with 41 g of mannitol, 10 g of microcrystalline cellulose, and 7.5 g of crospovidone , 13g of citric acid and 1g of lemon essence are mixed evenly, adding a mass fraction of 4% povidone K30 solution to make a soft material, granulating with a 24-mesh sieve, drying at 60°C, and sizing the dry granules through a 24-mesh sieve; Add 7.5g of crospovidone, 10g of sodium bicarbonate, 1g of magnesium stearate and 1g of micropowder silica gel to the granules, mix well, and press into tablets to make 1000 orally disintegrating tablets of pridinol mesylate, each Contains pridinol mesylate 4mg.

[0061] quality The obtained orally disintegrating tablet has a smooth and beautiful surface; it completely disintegrates in 26 seconds in water at 37±1°C and passes through a 30-mesh sieve; the hardness is 20-4...

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Abstract

The invention discloses a methylsulfonic acid pridinol oral disintegrating tablet and a preparation method thereof, wherein the oral disintegrating tablet comprises the following components by mass percentage: 2 to 8 percent of methylsulfonic acid pridinol, 40 to 80 percent of filler, 5 to 20 percent of disintegrant, 5 to 30 percent of effervescent agent, 1 to 5 percent of lubricant and 0.5 to 5 percent of flavoring agent. The methylsulfonic acid pridinol oral disintegrating tablet can be quickly disintegrated in mouth cavity and quickly absorbed, and takes effect quickly, has small first-passeffect on liver, high bioavailability, low acrimony to gastrointestinal tract, convenient taking and good taste, and is particularly suitable for the old, children and patients with difficult swallowing or inconvenient drinking of water, or in operation or coma; and the oral disintegrating tablet is prepared by adopting a method of wet granulation and compression or a method of direct compressionof powder, has simple production technique, low cost, easily-controlled quality, and stability, safety and effectiveness of the preparation, is suitable for large-scale industrial production and haswide market prospect.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a pridinol mesylate orally disintegrating tablet, and also relates to a preparation method of the orally disintegrating tablet. Background technique [0002] Pridinol Mesilate (Pridinol Mesilate, the following structural formula) is a depolarizing muscle relaxant that can bind to N on the motor nerve endplate membrane. 2 The combination of receptors can cause long-lasting depolarization of muscle cell membranes, weaken or disappear the response to acetylcholine, and lead to relaxation of skeletal muscles. It has a good curative effect; it can also be used as an auxiliary agent for general anesthesia. Under shallow general anesthesia, it can obtain the muscle relaxation required for surgery, thereby reducing the amount of general anesthesia. At present, the preparations of pridinol mesylate on the market abroad mainly include ordinary compressed tablets, coated tablets, enteric-coa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4453A61P21/02
Inventor 罗永煌田朋鑫聂延君乔彦茹刘艳玲罗雷雷曙光陈君
Owner SOUTHWEST UNIVERSITY
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