The invention provides a pharmaceutical composition for treating and preventing cardiovascular and cerebrovascular diseases, containing 80 parts by weight of grenadine juice, 180 parts by weight of antioxidant and a pharmaceutically acceptable carrier, wherein the antioxidant is one or the composition of many of the raw materials or raw material extracts or raw material concentrates of rice hull,carrot, pumpkin, cinnamon, broccoli, strawberry, blueberry, raspberry, green tea, sealwort, bitter caramon, tomato, pumpkin seed, resveratrol, vitamin E, vitamin C, grape pip, Brazil nut, Brazil large cherry, barley bran, rosemary, walnut leaf, tamarindus seed coat, cabbage, spinach, garlic and the like. The pharmaceutical composition provided by the invention has certain application values in treating or preventing cardiovascular and cerebrovascular diseases, treating or preventing hypertension, treating or preventing cardiovascular smooth muscle spasm and expanding the vascular smooth muscle.