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Pharmaceutical composition for treating and preventing cardiovascular and cerebrovascular diseases

A technology for cardiovascular and cerebrovascular diseases and compositions, applied in the field of pharmaceutical compositions for treating and preventing cardiovascular and cerebrovascular diseases, and pharmaceutical compositions for relaxing cardiovascular and cerebrovascular smooth muscles

Active Publication Date: 2013-04-24
北京富丽华德生物医药科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But do not see so far, pomegranate juice or the report that the pharmaceutical composition containing pomegranate juice relaxes vascular smooth muscle, the applicant has found a kind of traditional Chinese medicine composition containing pomegranate juice etc. that provides the effect of relaxing vascular smooth muscle

Method used

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  • Pharmaceutical composition for treating and preventing cardiovascular and cerebrovascular diseases
  • Pharmaceutical composition for treating and preventing cardiovascular and cerebrovascular diseases
  • Pharmaceutical composition for treating and preventing cardiovascular and cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0037] Experimental Example 1 The relaxation effect of the pharmaceutical composition of the present invention on the aortic blood vessels of mice

[0038] The mice were 100 male Kunming mice over 3 weeks old, purchased from the Institute of Experimental Animals, Chinese Academy of Medical Sciences. Use the granule dosage form to feed the mice, 2 times a day, each 2mg sample, measure 20 mice fed the pharmaceutical composition on 20, 40, 60, 80, 100 days, and use 20 mice as a blank control . The result is as figure 1 shown. The method for measuring the relaxation rate is to kill the mice, remove the thoracic aorta quickly, peel off the fat and part of the connective tissue on the adventitia surface, cut into 4 mm aortic blood vessel rings, and put the samples into 10 ml of Krebs solution (Krebs The liquid contains NaCl 119.0, KCl 4.7, CaCl in parts by weight 2 2.5, KH 2 PO 4 1.2, MgSO 41.2. NaHCO 3 25.0 and glucose 10.0 and water 1000). During the experiment, the pH ...

experiment example 2

[0039] Experimental Example 2 Effect of the pharmaceutical composition of the present invention on the cardiovascular system of rabbits.

[0040] Method: Japanese big-eared white rabbits (purchased from Xi'an Dilepu Biological Resources Development Co., Ltd., specification 2010-003) were divided into a sample group and a control group. The sample group was given a liquid dosage form and administered 12 mg / kg sample intravenously. Blood was collected from the middle ear artery to measure plasma cGMP content and hemorheology indicators

[0041] Results: a. Changes of plasma cGMP content

[0042] After taking 12mg / kg of the sample, the plasma cGMP content increased significantly and reached the peak within 2 hours. The detection method is the same as in Experimental Example 1, and the results are shown in Table 1.

[0043] b. Changes in blood viscosity

[0044] After taking the sample, the whole blood viscosity decreased significantly, and the decrease was most significant aft...

Embodiment 2

[0064] Example 2 illustrates that the pharmaceutical composition of the present invention can be used to improve the content of cGMP, regulate vasodilation, reduce blood viscosity and reduce platelet aggregation, that is, it can be used to treat or prevent vasospasm-related diseases and atherosclerosis-related diseases .

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Abstract

The invention provides a pharmaceutical composition for treating and preventing cardiovascular and cerebrovascular diseases, containing 80 parts by weight of grenadine juice, 180 parts by weight of antioxidant and a pharmaceutically acceptable carrier, wherein the antioxidant is one or the composition of many of the raw materials or raw material extracts or raw material concentrates of rice hull,carrot, pumpkin, cinnamon, broccoli, strawberry, blueberry, raspberry, green tea, sealwort, bitter caramon, tomato, pumpkin seed, resveratrol, vitamin E, vitamin C, grape pip, Brazil nut, Brazil large cherry, barley bran, rosemary, walnut leaf, tamarindus seed coat, cabbage, spinach, garlic and the like. The pharmaceutical composition provided by the invention has certain application values in treating or preventing cardiovascular and cerebrovascular diseases, treating or preventing hypertension, treating or preventing cardiovascular smooth muscle spasm and expanding the vascular smooth muscle.

Description

technical field [0001] The invention belongs to the field of medicine and health products, and relates to a pharmaceutical composition for treating and preventing cardiovascular and cerebrovascular diseases, in particular to a pharmaceutical composition for relaxing cardiovascular and cerebrovascular smooth muscles. Background technique [0002] Cardiovascular and cerebrovascular smooth muscle spasm can cause multiple diseases, such as hypertension, coronary artery spasm heart disease (such as angina pectoris, myocardial infarction, etc.), cerebral vasospasm disease (cerebral blood supply insufficiency, migraine), peripheral vasospasm disease (multiple Takayasu arteritis, Raynaud's syndrome) and pulmonary hypertension and other diseases. Among them, hypertension is the disease with the highest incidence rate among cardiovascular diseases in our country. Sustained high blood pressure will lead to stroke, heart disease, hemangioma, renal failure and other complications, which ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K36/23A61K36/31A61K36/42A61K36/45A61K36/48A61K36/52A61K36/53A61K36/54A61K36/73A61K36/736A61K36/81A61K36/82A61K36/87A61K36/8962A61K36/8969A61K36/899A61K36/8998A61K36/9062A61P9/10A61K31/05A61K31/355A61K31/375
Inventor 刘万涛陈振兴苏雨雷
Owner 北京富丽华德生物医药科技股份有限公司
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