The present invention discloses black sesame mixing nutrition medicinal granules and a preparation method thereof, wherein the raw materials comprise, by weight, 25-27 parts of black sesame, 20-22 parts of black beans, 15-17 parts of black fruit chinese wolfberry, 4-6 parts of lotus leaf, 2-4 parts of mulberry leaf, 9-11 parts of wax gourd seed, 10-12 parts of bitter gourd, 8-10 parts of carica papaya, 2-4 parts of green tea, 13-15 parts of coconut, 5-7 parts of annona squamosa, 8-12 parts of lucuma nervosa, 7-9 parts of kadsura coccinea, 4-6 parts of lonicera fragrantissima, 3-5 parts of chrysophyllum cainito, 2-4 parts of calcium fruit, 1-3 parts of coix seed powder, 1-3 parts of angelica dahurica powder, 1-3 parts of panax notoginseng powder, and 16-20 parts of brown sugar. The black sesame mixing nutrition medicinal granules of the present invention has characteristics of complete nutrition and good taste, and further has effects of blood fat lowering, blood pressure stabilizing, and blood nourishing.