41 results about "Apoptosis resistance" patented technology

A series of stapled BCL-2 family peptide helices were identified as able to target the survival protein MCL-I with high affinity and a subset with unprecedented selectivity. Agents and methods for selective pharmacologic neutralization of MCL-I are provided for drug discovery and therapeutic uses, including use in overcoming the apoptotic resistance of cancer and other diseases associated with impaired cell death.

The invention relates to the use of dichloroacetate and chemical equivalents thereof for the treatment of cancer by inducing apoptosis or reversing apoptosis-resistance in a cell Preferably, the dosage is 10-100 mg / kg Preferably, sodium dichloroacetate is used. The dichloroacetate may optionally be given in combination with a pro-apoptotic agent and / or a chemotherapeutic agent Preferably, the cancers treated are non-small cell lung cancer, glioblastoma and breast carcinoma.

The invention discloses an application of physalin A in preparation of a JAK2-STAT3 signal channel inhibitor and an antitumor drug. The physalin A is a compound with a structure shown in a formula I. The JAK2-STAT3 signal channel inhibitor can inhibit various tumor cells. As the JAK2-STAT3 is abnormally activated to lead to uncontrollable growth of tumor and apoptosis resistance of tumor cells, tumor cell proliferation is further inhibited and tumor cell apoptosis is further induced. The physalin A can be applied to preparation of the antitumor drug. The physalin A is combined with the chemotherapeutic drug (cis-platinum) can remarkably inhibit tumor cell proliferation so as to realize the purpose of enhancing effect and reducing toxicity. Particularly, the physalin A and cis-platinum combined in use to prepare the antitumor drug troches can generate a very strong synergistic effect, and the antitumor drug troches prepared have very good antitumor activity.

The invention discloses a titanium dental implant material and a preparing method and application of the titanium dental implant material. The titanium dental implant material prepared through the preparing method of the titanium dental implant material comprises a base body, a cationic polymer layer, an anion polysaccharide layer-chlorination chitosan-polypeptide A conjugate composite layer and an anion polysaccharide layer-antimicrobial peptide layer composite layer. The titanium dental implant material has good biocompatibility, bacterium resistance, apoptosis resistance and angiogenesis promoting activity, can support adhesion, survival, proliferation and differentiation of various cells, promotes survival, proliferation and migration of vascular endothelial cells, forms a lumen structure of a capillary tube sample and meanwhile inhibits adhesion and survival of periodontal common pathogenic bacteria. The titanium dental implant material has durable and efficient sterilizing and infection resisting capabilities, healing of peripheral bone wounds of the implant can be accelerated, chemical bonding of an implant-bone interface can be achieved, the success rate of oral implantology is increased, the treatment time is shortened, in addition, the preparing method is simple, and a good application prospect is achieved in the oral implantology field.