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A kind of titanium dental implant material and its preparation method and application

A technology for dental implants and substrates, applied in the field of oral implant material preparation, can solve the problems of lack of biocompatibility, lack of chemical combination, affecting the treatment effect, etc., and achieve the effect of shortening the treatment time, strengthening the proliferation activity and promoting the survival.

Inactive Publication Date: 2017-12-08
AFFILIATED HOSPITAL CHINA ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Titanium is an inert material, and the tissue reaction after implantation in the body shows a certain degree of non-specificity and randomness. The interface with bone tissue is mainly manifested as physical integration of mechanical locking, lack of effective chemical combination, and more importantly, due to its lack of Biocompatibility, after implantation, it will cause a series of inflammatory reactions, which will eventually affect the therapeutic effect

Method used

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  • A kind of titanium dental implant material and its preparation method and application
  • A kind of titanium dental implant material and its preparation method and application
  • A kind of titanium dental implant material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1, preparation dental implant material 1

[0049] 1. Preparation of Dental Implant Material 1-A

[0050] Dental implant material 1-A consists of a titanium sheet (substrate), a poly-L-lysine layer (cationic polymer layer) coated on the surface of the titanium sheet, and sulfuric acid coated on the surface of the poly-L-lysine layer. Chondroitin layer-chlorinated chitosan-polypeptide A conjugate layer composite layer (anionic polysaccharide layer-chlorinated chitosan-polypeptide A conjugate layer composite layer), coated on chondroitin sulfate layer-chlorinated shell The chondroitin sulfate layer-antibacterial peptide layer composite layer (anionic polysaccharide layer-antibacterial peptide layer composite layer) on the surface of the polysaccharide-polypeptide A conjugate layer composite layer; the chondroitin sulfate layer-chlorinated chitosan-polypeptide A The composite layer is composed of a chondroitin sulfate layer and a chlorided chitosan-polypeptide A...

Embodiment 2

[0068] Embodiment 2, preparation of dental implant material 2 and functional verification

[0069]1. Preparation of Dental Implant Material 2-A

[0070] Dental implant material 2-A consists of a titanium sheet (substrate), a poly-L-lysine layer (cationic polymer layer) coated on the surface of the titanium sheet, and sulfuric acid coated on the surface of the poly-L-lysine layer. Chondroitin layer-chlorinated chitosan-polypeptide A conjugate layer composite layer (anionic polysaccharide layer-chlorinated chitosan-polypeptide A conjugate layer composite layer), coated on chondroitin sulfate layer-chlorinated shell Chondroitin sulfate layer-antimicrobial peptide layer composite layer (anionic polysaccharide layer-antimicrobial peptide layer composite layer) on the surface of polysaccharide-polypeptide A conjugate layer composite layer, chondroitin sulfate layer-chlorinated chitosan-polypeptide A conjugate The composite layer is composed of a chondroitin sulfate layer and a chlo...

Embodiment 3

[0119] Embodiment 3, preparation dental implant material 3

[0120] 1. Preparation of Dental Implant Material 3-A

[0121] The dental implant material 3-A consists of a titanium sheet (substrate), a poly-L-lysine layer (cationic polymer layer) coated on the surface of the titanium sheet, and sulfuric acid coated on the surface of the poly-L-lysine layer. Chondroitin layer-chlorinated chitosan-polypeptide A conjugate layer composite layer (anionic polysaccharide layer-chlorinated chitosan-polypeptide A conjugate layer composite layer), coated on chondroitin sulfate layer-chlorinated shell Chondroitin sulfate layer-antimicrobial peptide layer composite layer (anionic polysaccharide layer-antimicrobial peptide layer composite layer) on the surface of polysaccharide-polypeptide A conjugate layer composite layer, chondroitin sulfate layer-chlorinated chitosan-polypeptide A conjugate The composite layer is composed of a chondroitin sulfate layer and a chlorided chitosan-polypeptide...

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Abstract

The invention discloses a titanium dental implant material and a preparing method and application of the titanium dental implant material. The titanium dental implant material prepared through the preparing method of the titanium dental implant material comprises a base body, a cationic polymer layer, an anion polysaccharide layer-chlorination chitosan-polypeptide A conjugate composite layer and an anion polysaccharide layer-antimicrobial peptide layer composite layer. The titanium dental implant material has good biocompatibility, bacterium resistance, apoptosis resistance and angiogenesis promoting activity, can support adhesion, survival, proliferation and differentiation of various cells, promotes survival, proliferation and migration of vascular endothelial cells, forms a lumen structure of a capillary tube sample and meanwhile inhibits adhesion and survival of periodontal common pathogenic bacteria. The titanium dental implant material has durable and efficient sterilizing and infection resisting capabilities, healing of peripheral bone wounds of the implant can be accelerated, chemical bonding of an implant-bone interface can be achieved, the success rate of oral implantology is increased, the treatment time is shortened, in addition, the preparing method is simple, and a good application prospect is achieved in the oral implantology field.

Description

technical field [0001] The invention relates to a titanium dental implant material and its preparation method and application in the technical field of oral implant material preparation. Background technique [0002] With the development of oral implantology, dental implant restoration technology has gradually become a routine treatment method, which has greatly improved the effect of dental restoration and improved the quality of life of patients. However, the current implant repair also has problems such as a long healing time after implantation, and a high failure rate in parts with poor bone quality and bone quantity. The response of the implant-tissue interface is one of the important factors that determine the success of dental implants. There are currently more than 220 registered dental implant systems, all of which are made of commercial high-purity titanium (cpTi) and its alloys (Ti-6Al-4V). Titanium is an inert material, and the tissue reaction after implantatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/22A61L27/20A61L27/18A61L27/06A61L27/54A61L27/50
Inventor 舒瑶葛成邹敬才龙国平于开涛孙海燕张欣李霞李齐宏王颖初晓阳党军邹璇
Owner AFFILIATED HOSPITAL CHINA ACADEMY OF MILITARY MEDICAL SCI
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