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Application of purified motherwort extract in preparing nerve protection medicine for treating cerebral injury

A technology of motherwort extract and neuroprotection, which is applied in the preparation of brain protection drugs for the treatment of middle cerebral artery occlusion, and the purified motherwort extract can solve the problems of no neuroprotective drugs.

Inactive Publication Date: 2009-12-09
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no report about the neuroprotective drug that purified HL (pHL) can prevent irreversible brain damage caused by various neurochemical reactions

Method used

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  • Application of purified motherwort extract in preparing nerve protection medicine for treating cerebral injury
  • Application of purified motherwort extract in preparing nerve protection medicine for treating cerebral injury
  • Application of purified motherwort extract in preparing nerve protection medicine for treating cerebral injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1 in vivo test

[0050] The experimental scheme of the present invention is certified by the ethics association and complies with international ethics standards. Experimental animals (purchased from the Experimental Animal Center of the National University of Singapore).

[0051] 84 Wistar rats weighing 220g to 250g were housed in cages under daytime light and given sufficient food and water. Rats were randomly divided into four groups: sham operation group [Sham], sham operation pHL treatment group (400mg / kg / day) [Sham+pHL], stroke model group [Vehicle], stroke pHL treatment group (400mg / kg / day) kg / day) [Sroke+pHL]. Administer orally every day. Two weeks before surgery, pre-administration, occlusion of the middle cerebral artery (MCAO) in rats resulted in stroke. First, rats were anesthetized with a mixture of ketamine / xylazine (0.1ml / 100gi.p.), the middle cerebral artery was isolated, and the section from the intersection with the inferior cerebral vein...

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PUM

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Abstract

The invention belongs to the field of pharmacy and relates to a new application of a traditional Chinese medicine motherwort extract in pharmacy, in particular to the application of the purified motherwort extract in preparing nerve protection medicine for treating cerebral injury, especially the application of the purified motherwort extract in preparing brain protection medicine for treating artery obstruction in the brain. By an animal experiment of the purified motherwort extract, a result indicates that the brain stem volume is obviously reduced after the purified motherwort extract is applied, the obstacle grading of the nerve function is decreased by being compared with a contrast group, the total antioxidant concentration in plasma is increased, the DNA oxidation injury is reduced, the expression levels of apoptosis and apoptosis promoting protein are reduced, and the content of apoptosis resistance protein is also increased. The purified motherwort extract can be used for preparing the nerve protection medicine for treating the cerebral injury and can effectively treat cerebral apoplexy.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to the new application of the extract of Motherwort Herb in pharmacy, in particular to the use of purified Motherwort Extract HL (pHL) in the preparation of neuroprotective drugs for brain damage, especially the use of the purified Motherwort Extract in the preparation of Use in brain-protective drugs for treating middle cerebral artery occlusion. Background technique [0002] The prior art discloses that ischemic stroke is caused by reduced or complete occlusion of blood flow resulting in insufficient local blood sugar and oxygen supply. Currently the most effective treatment is thrombolytic therapy, but only some stroke patients can accept this therapy. Therefore, it is urgent to develop neuroprotective drugs that have a wide therapeutic window and can prevent irreversible brain damage caused by various neurochemical reactions. [0003] Under normal physiological conditions, endogenous ant...

Claims

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Application Information

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IPC IPC(8): A61K36/533A61K31/352A61P25/00A61K31/235
Inventor 朱依谆朱依纯
Owner FUDAN UNIV
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