87 results about "Acid stable" patented technology

Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2′-arabino-fluoronucleoside and an internucleoside 3′-NH—P(—O)(OR)—O-5′ linkage, where R is a positively charged counter ion or hydrogen, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive phosphoramidate 2′-arabino-fluorooligonucleotides have a high RNA binding affinity to complementary nucleic acids and are base and acid stable.

This invention provides a method of inactivating human noroviruses and other acid stable viruses. The method includes the step of contacting the virus with a virucidally-enhanced alcoholic composition that includes an alcohol, and an enhancer selected from cationic oligomers and polymers, chaotropic agents, and mixtures thereof.

The invention described relates to gelled chlorine dioxide compositions comprising water, an acid, a water-soluble chlorite salt and a gelling agent in two parts A and B, wherein the gelling agent is xanthan gum or a mixture of xanthan gum and an acid stable gelling agents. Compositions according to the invention are storage stable for at least 6 months, preferably at least about year.

Semi-permeable membranes are described that allow for the efficient processing of many liquid based feed solutions, particularly those that contain acids. The membranes of this invention are able to process such feeds with high permeate rates while maintaining excellent retention of dissolved metals, cations, and organic compounds, even in the presence of hot concentrated acids. The semi-permeable membranes of this invention are able to conduct such separations for a useful period of time due to their chemical stability towards acids and their ability to permeate acids.

Semi-permeable membranes are described that allow for the efficient processing of many liquid based feed solutions, particularly those that contain acids. The membranes of this invention are able to process such feeds with high permeate rates while maintaining excellent retention of dissolved metals, cations, and organic compounds, even in the presence of hot concentrated acids. The semi-permeable membranes of this invention are able to conduct such separations for a useful period of time due to their chemical stability towards acids and their ability to permeate acids.

A positive resist composition comprising: (A) a resin showing an increase in the solubility in an alkali developer by the action of an acid; (B) a compound being capable of generating an acid when irradiated with an actinic ray or a radiation; (C) a resin having a silicon-containing repeating unit of a specific structure and being stable to acids but insoluble in an alkali developer; and (D) a solvent; and a pattern making method using the same.

Aqueous coating compositions containing acid stable metal dispersions, prepared by chemical reduction in aqueous medium, are obtained by using a N-quaternized cellulose derivative as binder. They can be used for the preparation of heat mode recording layers, magnetic layers and conductive layers.

A method is presented for making alkoxy-modified silsesquioxanes (AMS) or co-alkoxy-modified silsesquioxanes (co-AMS,) comprising the steps of (a) combining as a reaction mixture (i) water, (ii) an acid-stable solvent for the water, (iii) a solid strong cationic hydrolysis and condensation catalyst, and (iv) a trialkoxysilane compound, (b) allowing the reaction mixture to react for about 0.5 hours to about 200 hours to form the alkoxy-modified silsesquioxanes; and (c) recovering the alkoxy-modified silsesquioxanes from the reaction mixture. The use of solid strong cationic catalysts in this reaction system is advantageous because they remain as solids throughout the reaction, allowing simplified separation of the solid catalyst from the soluble AMS or co-AMS products, resulting in total or near total recovery of the AMS or co-AMS products, the products being free of, or substantially free of residual acid catalyst, as well as virtual total recovery of the catalyst for recycling. The improved AMS and co-AMS compounds, vulcanizable rubber compounds containing them, and a pneumatic tire having a component made from the vulcanized rubber compounds are also presented.

Disclosed are acid-stable compounds of Formula I: as well as pharmaceutical compositions containing the compounds as active ingredients, and methods to treat cancers in mammal, including humans, by administering one or more of the compounds to a subject in need thereof. The compounds are resistant to acid hydrolysis.

A method is presented for making alkoxy-modified silsesquioxanes (AMS) or co-alkoxy-modified silsesquioxanes (co-AMS,) comprising the steps of (a) combining as a reaction mixture (i) water, (ii) an acid-stable solvent for the water, (iii) a solid strong cationic hydrolysis and condensation catalyst, and (iv) a trialkoxysilane compound, (b) allowing the reaction mixture to react for about 0.5 hours to about 200 hours to form the alkoxy-modified silsesquioxanes; and (c) recovering the alkoxy-modified silsesquioxanes from the reaction mixture. The use of solid strong cationic catalysts in this reaction system is advantageous because they remain as solids throughout the reaction, allowing simplified separation of the solid catalyst from the soluble AMS or co-AMS products, resulting in total or near total recovery of the AMS or co-AMS products, the products being free of, or substantially free of residual acid catalyst, as well as virtual total recovery of the catalyst for recycling. The improved AMS and co-AMS compounds, vulcanizable rubber compounds containing them, and a pneumatic tire having a component made from the vulcanized rubber compounds are also presented.

A water-soluble acid stable soy protein, methods for making same and acidic food or acidic beverage fortified therewith. Particularly, this invention is useful in the pH range of 3.5 to 4.1 where other soy protein fortification methods do not work. The invention is comprised of a soy protein, a thermal treatment method to solubilize at least 90% of the protein, an acidification of the protein to a point preferably significantly below the iso-electric value, and a partial neutralization to bring the product proximal to the intended pH of the application it will be used in.

This invention is directed to an acidic beverage composition, comprising; (A) a hydrated protein material having a combination of an inositol-6-phosphate content, an inositol-5-phosphate content, an inositol-4-phosphate content and an inositol-3-phosphate content of less than 8.0 μmol / g, with (B) a hydrated protein stabilizing agent and (C) at least one acid comprising a fruit juice, a vegetable juice, citric acid, malic acid, tartaric acid, lactic acid, ascorbic acid, glucono delta lactone or phosphoric acid, wherein the acidic beverage composition has a pH of from 3.0 to 4.5.

The present invention relates to formulations comprising therapeutically effective amounts of at least one acid-stable, carrier-mediated transport statin, at least one poorly water-soluble, carrier-mediated transport statin, or at least one large molecular weight, carrier-mediated transport statin, such as atorvastatin and rosuvastatin, or a pharmaceutically acceptable salt thereof, and methods of their use. The present formulations and methods are designed to exhibit a controlled-release of a therapeutic amount of the statin in the small intestine, thereby limiting systemic exposure of the statin and maximizing liver-specific absorption of the drug. The formulations and methods of the present invention are particularly useful for treating and / or preventing conditions that are benefited by decreasing levels of lipids and / or cholesterol in the body.

The invention relates to a mutant strain of a high temperature acid-proof Alpha-amylase and a method for producing the mutant strain. The high temperature acid-proof Alpha-amylase gene is obtained by mutating the Bacillus licheniformis high-temperature resistant Alpha-amylase gene (Leu134 Arg and Ser320 Ala); the high temperature acid-proof Alpha-amylase gene is integrated into the genom DNA of the parent strain Bacillus licheniformis by establishing a target carrier and by adopting the method of homologous recombination so that the Bacillus licheniformis mutate strain is obtained to realize the homology effective expression of the high temperature acid-proof Alpha-amylase gene. The Alpha-amylase produced by the mutate strain is resistant to high temperature and has the acid stability improved evidently, thereby providing good technique condition for the starch deep processing industry such as alcohol and mashing in China, lowering the cost, saving the energy and the industrial grain, and satisfying the requirements of the starch raw material liquefying technique on acid conditions.

A coating composition comprising an aqueous mixture containing acid-stable particles and one or more fluoroacids. The amount of the acid-stable particles in the coating composition is from 0.005% to 8% by weight on a dry weight basis. The acid-stable particles can be selected from aluminum-modified silica particles, nonaluminum-modified silica particles, and organic particles selected from anionically stabilized polymer dispersion particles. The invention is also directed to a coating on a metal substrate. The coating contains acid-stable particles attached to the metal substrate through a metal-oxide matrix. The metal-oxide matrix comprises a metal selected from titanium, zirconium, silicon, hafnium, boron, aluminum, germanium, or tin.

The invention relates to a composition including an acid-stable inorganic binder and fibres. The composition includes at least one inorganic binder and fibres, wherein the inorganic binder comprises water glass, the fraction of the composition which is attributable to water glass preferably being in the range from 2% to 99% by weight or 6% to 94% by weight or 11% to 89% by weight or 21% to 79% by weight. The fibre material is present as a weave and / or knit and / or scrim and / or net and / or brous nonwoven web and / or as hollow fibres. Owing to its high strength coupled with low weight, this material of construction is very useful for fabricating ready-made components for structural and civil engineering. In addition, it is also very easy to produce structural components and engineered structures on site. It is possible to realize very light components, to achieve very delicate geometries and, owing to the favourable strength-to-weight ratio, to build unusually high structures.

The present invention relates to methods of producing a heterologous biological substance, comprising: (a) cultivating a mutant of a parent Aspergillus niger strain in a medium suitable for the production of the heterologous biological substance, wherein (i) the mutant strain comprises a first nucleotide sequence encoding the heterologous biological substance and one or more second nucleotide sequences comprising a modification of glaA and at least one of the genes selected from the group consisting of asa, amyA, amyB, prtT, and oah, and (ii) the mutant strain is deficient in the production of glucoamylase and at least one enzyme selected from the group consisting of acid stable alpha-amylase, neutral alpha-amylase A, and neutral alpha-amylase B, protease, and oxalic acid hydrolase compared to the parent Aspergillus niger strain when cultivated under identical conditions; and (b) recovering the heterologous biological substance from the cultivation medium. The present invention also relates to enzyme-deficient mutants of Aspergillus niger strains and methods for producing such mutants.

A fire-resistant and acid-proof alpha-amylase and its production are disclosed. The process is carried out by separating precursor-alpha-amylase gene from lichenized bacillosporin, mutating for L134 and S320 amino acid residues and high-efficient expressing alpha-amylase mutant in bacterium. It achieves better safety, expression and acid stability, and more yield.

A positive resist composition comprises: (A) a resin of which solubility in an alkali developer increases under the action of an acid, (B) a compound capable of generating an acid upon irradiation with actinic rays or radiation, (C) a resin having at least one repeating unit selected from fluorine atom-containing repeating units represented by the following formulae (1-1), (1-2) and (1-3), the resin being stable to an acid and insoluble in an alkali developer, and (D) a solvent: wherein R1 represents a hydrogen atom or an alkyl group; R2 represents a fluoroalkyl group; R3 represents a hydrogen atom or a monovalent organic group; R4 to R7 each independently represents a hydrogen atom, a fluorine atom, an alkyl group, a fluoroalkyl group, an alkoxy group or a fluoroalkoxy group, provided that at least one of R4 to R7 represents a fluorine atom, and R4 and R5, or R6 and R7 may combine to form a ring; R8 represents a hydrogen atom, a fluorine atom or a monovalent organic group; Rf represents a fluorine atom or a fluorine atom-containing monovalent organic group; L represents a single bond or a divalent linking group; Q represents an alicyclic structure; and k represents an integer of 0 to 3.

The present invention relates to an enzyme blend composition comprising a glucoamylase, an acid stable alpha amylase, and an acid fungal protease. The present invention is further directed to a method for producing end products such as alcohols from fermentable sugars, comprising the steps of: (a) contacting a slurry comprising a milled grain that contains starch with an alpha amylase to produce a liquefact; (b) contacting the liquefact with a glucoamylase, an acid stable alpha amylase, and an acid fungal protease, to produce fermentable sugars; and (c) fermenting the fermentable sugars in the presence of a fermenting organism to produce end products.

The invention discloses a compound acid stabilizer for anthocyanidin. The compound acid stabilizer is prepared from 8-16 parts of 50% of D-gluconic acid in percentage by weight, 4-8 parts of ferulic acid and 2-6 parts of coffeic acid. The compound acid stabilizer for the anthocyanidin is diluted 60-100 times with a pH 3.0 phosphate buffer reacts with 4 parts of the anthocyanidin under the reaction condition that the pressure is 100-400 MPa and pressurization is conducted for 1-5 min; stabilized anthocyanidin is obtained, the treated anthocyanidin is modified properly, the light and heat stability is improved, and the storage life is long. Edible organic acid can improve the activity of the anthocyanidin, compound acid has higher removal rate for DDPH and ABTS, has the removing capacity higher than 90% for the DDPH and the ABTS at the low concentration of 20[mu]g / mL and is several times higher than a control and VC, and the antioxidant activity of the anthocyanidin is improved. The anthocyanidin is extracted by a non-thermal high-voltage pulsed electric field, thus, the extraction rate is increased.

A water-soluble acid stable soy protein, methods for making same and acidic food or acidic beverage fortified therewith. Particularly, this invention is useful in the pH range of 3.5 to 4.1 where other soy protein fortification methods do not work. The invention is comprised of a soy protein, a thermal treatment method to solubilize at least 90 % of the protein, an acidification of the protein to a point preferably significantly below the iso-electric value, and a partial neutralization to bring the product proximal to the intended pH of the application it will be used in.

A coating composition comprising an aqueous mixture containing acid-stable particles and one or more fluoroacids. The amount of the acid-stable particles in the coating composition is from 0.005% to 8% by weight on a dry weight basis. The acid-stable particles can be selected from aluminum-modified silica particles, nonaluminum-modified silica particles, and organic particles selected from anionically stabilized polymer dispersion particles. The invention is also directed to a coating on a metal substrate. The coating contains acid-stable particles attached to the metal substrate through a metal-oxide matrix. The metal-oxide matrix comprises a metal selected from titanium, zirconium, silicon, hafnium, boron, aluminum, germanium, or tin.

A process of forming on a metal substrate a composition prior to the substrate being cold worked. The process includes a step of contacting the substrate with an aqueous composition comprising acid-stable particles and one or more fluoroacids. The amount of the acid-stable particles in the coating composition is from 0.005% to 8% by weight on a dry weight basis.

The present invention relates to a liposomal formulation for oral delivery of a bioactive agent that considers pH stability and oxidative stability of a bioactive ingredient. These lipid formulations are superior to conventional liposomes due to their stability, thereby circumventing the need for intra-venous delivery of bioactive agents. In one embodiment, the methods and compositions of the present invention relate to the oral delivery of insulin or a prodrug thereof.

This invention relates to a method of producing powders and liquids containing milk proteins, which are stable in an acidic medium. In particular, the invention is concerned with a method of producing a powder which can be mixed with water, milk or juice to form a stable, acidified, high protein beverage. Moreover, the invention extends to a method of producing a carbonated, flavoured milk beverage or a carbonated, acidified flavoured milk beverage that is stable in an acidic medium. The invention also discloses methods of producing yoghurt style beverages and cream cheese by blending a stabilised acid component and a stabilised protein component to form an acidified protein component.