A composition for modulating cytokines to regulate an inflammatory or immunomodulatory response. The composition can include at least one of rosehips, blueberry, blackberry, elderberry, cranberry, rosemary, clove, feverfew, nettle root, artichoke, reishi
mushroom,
olive extract,
green tea extract,
grape seed extract,
resveratrol, Aframomum melegueta,
boswellia serrata extract,
boswellia forte, ipriflavone, tocotrienols,
evening primrose oil, INM-176,
borage oil,
krill oil, at least one type of
xanthophyll (e.g.,
astaxanthin),
green coffee extract and
ferulic acid. Specifically, a composition of the invention can include: rosehips and at least one of blackberry, blueberry, elderberry, and optionally
krill oil; or rosehips,
resveratrol and at least one of Aframomum melegueta and
astaxanthin. Based on the
cytokine modulation and
cytokine response inhibition of the composition, it can be used to regulate an immunomodulatory and / or
inflammatory response, and subsequently treat diseases and / or abnormal conditions associated with
inflammatory response, for example, cardiovascular conditions,
arthritis,
osteoporosis and Alzheimer's
disease.