The invention relates to a preparation method of (2R,3R)-1,4-dimethoxyl-1,1,4,4-tetraphenyl-2,3-
butanediol and (2S,3S)-1,4-dimethoxyl-1,1,4,4-tetraphenyl-2,3-
butanediol, which comprises the steps of preparing chiral 1,1,4,4-tetraphenyl butantetraol by carrying out hydrocarbylation on antipode purity (2R,3R)-tartaric ester and (2S,3S)-tartaric ester with a phenyl
Grignard reagent; and then reacting with a
boron compound in the presence of a
metal compound or an amino compound to generate chiral spiral borate to obtain the (2R,3R)-1,4-dimethoxyl-1,1,4,4-tetraphenyl-2,3-
butanediol and (2S,3S)-1,4-dimethoxyl-1,1,4,4-tetraphenyl-2,3-butanediol with high yield. The method has the remarkable characteristics of easy obtaining of raw materials (no need of special reagents or expensive reagents), simple process, convenient and simple operation, good reaction selectivity, high yield of products, and the like.