32results about How to "Quite active" patented technology

The invention relates to the field of biological medicine, in particular to an application of Rakicidins compounds in resistance to clinical pathogenic anaerobic bacteria. Pharmacodynamic experiments indicate that the Rakicidins compounds have good resistant effect on the clinical pathogenic anaerobic bacteria and have the resistant effect on vancomycin enterococcus infection diseases. The Rakicidins compounds can be used for treating diarrhea, enteritis, alimentary infection, oral infection or skin acne caused by clostridium difficile as well as diseases such as urinary tract infection, or skin soft-tissue infection and the like.

The invention provides a special catalyst composition of a hydrogenation conjugated diene polymer and a method for selectively hydrogenating the conjugated diene polymer by using the special catalyst composition. The method comprises the step of reacting conjugated diene polymer dissolved in an inert organic solvent with hydrogen in the presence of a hydrogenation catalyst composition to selectively hydrogenate unsaturated double bonds of conjugated diene units in the conjugated diene polymer. The hydrogenation catalyst composition comprises (a) a titanium compound, (b) a compound shown in a formula (II) and (c) an alkyl aluminum compound, wherein in the formula (II), R5 is alkyl, vinyl, amino, ether, ketone group or ester group of C1 to C12; R3 and R6 are alkyl or vinyl of C1 to C12; R4 and R7 are alkyl, vinyl, amino, ether, ketone group or ester group of C1 to C12; and n is more than or equal to 1 and less than or equal to 3, and m is more than or equal to 1 and less than or equal to 3.

The invention belongs to the technical field of hydrocarbon steam-reforming hydrogen production, relates to a low-cost hydrocarbon steam-reforming catalyst and a preparation method thereof. According to the preparation method, waste nickel hydrocarbon steam-reforming catalysts are utilized for preparing a novel catalyst in a low cost manner, recycled waste catalysts are preprocessed, all the catalysts accordant with the requirements can be recycled by utilizing a coprecipitation-wet mixing method, and a NiO/CaO-Al2O3 type catalyst is prepared after the catalysts are subjected to steam curing after-treatment and is suitable for high-class hydrocarbon steam-reforming hydrogen production; the use effect of the recycled the waste catalysts is remarkable, more than 95% of catalysts accordant with the requirements can be recycled, then 10-20% of production cost can be lowered, not only can waste catalysts be effectively recycled, the preparation cost of the catalyst is lowered, but also the environmental pollution caused by waste residues can be eliminated, the physical and chemical properties, activity and activity stability of the catalyst are similar to the physical and chemical properties, activity and activity stability of the catalyst prepared by utilizing a conventional method, and the preparation method is simple and feasible and is easy to implement.

The invention discloses camphoryl pyrimidines, and a preparation method and an anti-tumor activity study thereof. With camphor as a raw material and under an alkaline catalysis condition, a series ofalpha,beta-unsaturated ketones are obtained through aldol condensation reaction of camphor with different aromatic aldehydes respectively, a series of camphoryl pyrimidines are obtained through annulation reaction of alpha,beta-unsaturated ketones with guanidine hydrochloride through catalysis of potassium tert-butoxide, and the anti-tumor activity of the synthesized camphoryl pyrimidines is studied. Experiments show that the camphoryl pyrimidines have good inhibitory activity on human multiple myeloma cells (RPMI-8226), human breast cancer cells (MDA-MB-231) and human non-small cell lung cancer cells (A549), have less toxicity on normal cell human gastric mucosa cells (GES-1), and have potential anti-tumor application value.

The invention relate to acyloxy containing hydroxyalkyl polysiloxane and a preparation method. The preparation method comprises steps as follows: hydrogen containing polysiloxane and a hydroxyalkyl acrylate or hydroxyalkyl methacrylate compound are taken as raw materials, a polymerization inhibitor is added, and a target product of acyloxy containing hydroxyalkyl polysiloxane is generated through the hydrosilylation reaction of silicon-hydrogen bonds and unsaturated double bonds under the action of a platinum catalyst at the reaction temperature of 80-145 DEG C; after the reaction, the unreacted hydroxyalkyl acrylate or hydroxyalkyl methacrylate compound is washed and removed with water, water and a solvent are removed through reduced pressure distillation, the polymerization inhibitor is removed through filtering, and the target product of acyloxy containing hydroxyalkyl polysiloxane is obtained. Acyloxy containing hydroxyalkyl polysiloxane prepared with the method contains active terminated hydroxyalkyl, and when acyloxy containing hydroxyalkyl polysiloxane is applied to preparation of high polymer materials such as modified polyacrylate and the like, the functional performance of modified siloxane-acrylate copolymers is improved.

The invention provides a regeneration method for a palladium catalyst. According to the regeneration method, the palladium catalyst with the activity incapable of meeting the production requirements after being treated with the existing regeneration method can meet the requirement for activity or higher activity required by production. The regeneration method includes the following steps that 1, impurities are in a palladium catalyst needed to be regenerated are removed; 2, the palladium catalyst which is subjected to impurity removing is reacted with a sodium chlorate solution and hydrochloric acid; 3, the pH value of a solution reacted in the step 2 is adjusted to be 4 or above, and drying is carried out; 4, a sample dried in the step 3 is roasted.

The invention discloses a preparation method of a hydrodemetalization catalyst for residuum. The method comprises the following process: first impregnating an alumina carrier with a polyethylene glycol solution with the mass fraction of 20%-70%; then drying the impregnated alumina carrier; and finally loading an active component onto the alumina carrier, and drying and roasting to obtain the hydrodemetalization catalyst. The hydrodemetalization catalyst prepared by the method has activity similar to that of the catalyst of the prior art, and reduces the amount of active component and the cost of production.

The invention discloses camphoryl thiosemicarbazones, and a preparation method and an anti-tumor activity study thereof. With camphor as a raw material and under an alkaline catalysis condition, a series of alpha,beta-unsaturated ketones are obtained through aldol condensation reaction of camphor with different aromatic aldehydes respectively, then a series of camphoryl thiosemicarbazones are obtained through condensation of alpha,beta-unsaturated ketones with thiosemicarbazide through catalysis of concentrated hydrochloric acid, and the anti-tumor activity of all the target products is studied. Experiments show that the camphoryl thiosemicarbazones have good inhibitory activity on human multiple myeloma cells (RPMI-8226), human breast cancer cells (MDA-MB-231) and human non-small cell lung cancer cells (A549), have less toxicity on normal cell human gastric mucosa cells (GES-1), thereby having potential anti-tumor application value.

The invention belongs to the technical field of plant genetic engineering, and particularly relates to application of soybean gene promoters pRPS28 and pRPS28-I in soybeans, arabidopsis thaliana and tobaccos. According to the invention, a gene RPS28 and a gene EIF1 are cloned from soybeans; a promoter pRPS28 and a promoter pRPS28-I are obtained through a CTAB method, then a soybean stable transformation vector is constructed, expression of GUS protein driven by the pRPS28 and the pRPS28-I in all stages of soybean genetic transformation is achieved, it is found that the GUS driven by the pRPS28 and the pRPS28-I is expressed in cotyledons, radicles, germs, true leaves, compound leaves, buds, petioles, internodes, roots and root nodules, it is indicated that the pRPS28 and the pRPS28-I are pan-expression promoters, and the activity of the expression product of the GUS protein in the soybean is measured. In addition, the transformation of the GUS protein driven by the pRPS28 and the pRPS28-I in the transformation of the arabidopsis thaliana and the tobacco is also realized.

The invention relates to working place amplified microbiological product and its preparation manufacturing method. It includes microorganism bacteria species and nutrient. And their weight ratio is 1:5-1:500. The microorganism preparation can be formed by adding water, controlling temperature, and natural fermenting for the microbiological product. The invention can adjust the production according to actual demand, and make the preparation be used at the salad days. Meanwhile it realizes í‹zero package, zero transportation, and zero linkíŒ to make preparation manufacturing and using cost reduce, and make it be good for user using.

The present invention provides an isolated monoclonal antibody that specifically binds human TIM-3. The present invention further provides a pharmaceutical composition comprising the antibody, as wellas uses thereof. The invention further provides immunoconjugates, bispecific molecules, and pharmaceutical compositions comprising the antibodies, as well as diagnostic and therapeutic methods of using the anti-TIM-3 antibodies of the invention.

The invention discloses a shell-based nitrogen-doped activated carbon catalyst prepared by a one-step method. The method comprises the following steps: 1) preprocessing shells; 2) dipping shells in adipping solution containing a nitrogen source to obtain a catalyst precursor; and 3) carbonizing the catalyst precursor under the protection of inert gas to obtain the nitrogen-doped activated carboncatalyst. Compared with a preparation method taking activated carbon as a carrier, the preparation method takes shells (activated carbon precursor) as the carrier, the preparation process is more simplified, the production cost is greatly reduced, and the method is more energy-saving and environment-friendly. Compared with an organic micromolecular nitrogen-containing compound, amino resin has higher thermal stability, a catalyst with equivalent activity can be obtained under the condition of lower loading capacity, and the cost of raw materials is effectively saved.