Application of 7,3'-dimethoxy hesperetin in preparation of anti-inflammatory immune medicaments

Abstract

The pharmaceutical application of a hesperetin derivative relates to the application thereof in the preparation of anti-inflammatory immune medicaments, in particular to the application in treatment of autoimmune diseases such as rheumatic, rheumatoid arthritis and osteoarthritis, and the like. The hesperetin derivative is the derivative which is prepared by a non-carbohydrate compound obtained by hydrolyzing hesperidin and removing glycosyl. The pharmacological effect of the hesperetin derivative is significantly higher than that of the parent hesperidin; and compared with traditional non-steroidal anti-inflammatory medicament naproxen and a medicament tripterygium treating rheumatoid arthritis, the hesperetin derivative has equivalent activeness, is safe and non-toxic, not only treats the symptom, but also treats the root, thus having very good medicinal prospect.

Description

Technical field: [0001] The present invention is a divisional application of "Application of Hesperetin Derivatives as Anti-inflammatory and Immunological Drugs", original application number: 200610088016.8, filing date June 15, 2006. [0002] The present invention relates to the medical use of a flavonoid compound, specifically the medical use of hesperetin derivatives, especially the application in the preparation of anti-inflammatory immune drugs. Background technique: [0003] Inflammation is a common pathological process in the body caused by various injury factors, mediated by a variety of inflammatory mediators, mainly including prostaglandins (PGs) and leukotrienes (LTs). Immunity is a specific physiological reaction of the body when it comes into contact with antigenic foreign bodies or foreign components. Its function is to identify and eliminate antigenic foreign bodies to maintain the body's physiological balance. Both immune response and inflammatory response a...

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Problems solved by technology

Hesperidin tastes bitter, insoluble in water, slightly soluble in alcohol, easily soluble in lye, it has a wide range of biological activities, such as anti-tumor effect (Koyunku H, et al. Anticancer Res.1999, 19 (4B): 3237 -41), anti-inflammatory effect (Guardia, et al.Farmaco.2001, 56 (9): 683-7), therapeutic effect on CIA rats (KawaguchiK, et al.Planta Med.2006, 72: 477-9 ), antibacterial effect (Bae EA, et al.PlantaMed.1999, 65(5):442-3), antioxidant effect (Garg A, et al.Phytother Research, 2001, 15(8):655-69), However, the activity of hesperidin itself is low, and it can only be effective in large doses. At the same time, hesperidin itself has poor water solubility, is difficult to absorb after oral administration, and has low bioavailability. Therefore, it is difficult to directly use hesperidin as a therapeutic drug.

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