The invention provides a preparation method and application of a water-soluble amphobic modified material. The material is mainly formed by the hybridization of an amphobic component and a colloidal network. The specific components mainly include: a solvent, an amphobic component, a network body, As a modifier, a stable water-soluble amphiphobic modified material can be obtained through solution mixing and reaction. The invention has the advantages of simple process, low price, strong adaptability, etc., and the raw materials are environmentally friendly and non-toxic to human health. At the same time, the prepared Water-soluble amphiphobic modified materials can be mixed with water in any proportion. Adding them to latex paint, finish paint and other raw materials can make the material exhibit properties such as hydrophobic and oil-repellent, high strength, scrub resistance, and stain resistance. It can be applied to water-based Architectural coatings, surface protection, oil-water separation, clothing decoration, outer layer protection of electronic products, etc.