The invention belongs to the field of nickel-based high-temperature alloys, and particularly discloses a nickel-cobalt-based high-temperature alloy with favorable structure stability (no Ni3Ti phase separation) and easiness for processing. The nickel-cobalt-based high-temperature alloy can be processed by using a casting and forging (C and W) process and a powder metallurgy process and is mainly suitable for bearing parts with high stress at the high temperature of 750DEG C, such as a turbine disc and a blade material in an aeroengine. The nickel-cobalt-based high-temperature alloy comprises the following chemical components in percentage by weight: 0.1-10 percent of Ru, 22-35 percent of Co, 10-20 percent of Cr, 0.10-5 percent of Ta, 0.10-5 percent of W, 0.10-5 percent of Mo, 3-10 percent of Ti, 0.2-5 percent of Al, 0.01-0.10 percent of Zr, 0.10-1 percent of V, 0.10-5 percent of Nb, 0.1-2 percent of Hf, 0.005-0.15 percent of C, 0-2 percent of Fe, 0.01-0.1 percent of Mg, 0.05-0.50 percent of Mn, 0.005-0.1 percent of B and the balance Ni. According to the nickel-cobalt-based high-temperature alloy disclosed by the invention, the Ru element is added under the existence of a TMW alloy containing Co and Ti with high contents; and under the condition that the high temperature bearing capacity of the alloy is ensured, the structure stability (no Ni3Ti phase separation) and the processability of the alloy can be remarkably improved.