The invention relates to a traditional Chinese medicine composition to treat nocardiasis in Osphronemus goramy, comprising herba Pyrolae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Astragali, Fructus Rosae Laevigatae, Rhizoma Atractylodis Macrocephalae, Rhizoma Bletillae, Radix Angelicae Dahuricae, Herba Semiaquilegiae Adoxoidis, Rhizoma Sparganii, Spina Gleditsiae, Cortex Magnoliae Officinalis, Herba Agrimoniae, Lithargyrum and Radix Glycyrrhizae. Powder used herein to treat nocardiasis in Osphronemus goramy is made with the components all of which are green materials, is nontoxic and harmless to the environment, has no chemicals or antibacterial drugs and benefits healthy sustainable development of aquaculture; the powder can effectively prevent and treat nocardiasis in Osphronemus goramy, the cure rate is high, the survival rate of the diseased ones of Osphronemus goramy reaches 03% and above, red spots on Osphronemus goramy fade 2-3 days after medication, blood swelling disappears, flakes stop shedding, and the disease is effectively controlled.