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57results about How to "Good acupuncture" patented technology

Antibiotic oil-water double suspension type injection emulsion for livestock and preparation method thereof

The invention discloses an antibiotic oil-water double suspension type injection emulsion for livestock. The effective antibiotic components of the antibiotic oil-water suspension type injection emulsion are respectively suspended in an oil phase and a water phase, the water phase is in the outer layer and the oil phase is enveloped therein. In the invention, based on the metabolic characteristics of the effective antibiotic components in a target animal body, the effective antibiotic components of the end products of the new preparation are distributed in an equivalent or nonequivalent mode in different oil and water carriers to form the double suspension type emulsion. After the double suspension type emulsion is administered by intramuscular injection, the antibiotics present a split type secondary release characteristic, thus achieving quick acting and long acting combination. The invention has the characteristics that: (1) the preparation process is relatively simple, the materials can be acquired easily, and the preparation process is particularly suitable for large-scale production; (2) medicaments with different amounts of carriers can be designed according to the pharmacokinetic characteristics of different target animals on different antibiotics, thus achieving quick acting and long acting combination and the effect on treating infection, and the medicament is particularly suitable for clinical application; and (3) the carriers of the double suspension type emulsion can carry health raw materials for animals for preparing compound health products for animals.
Owner:HUNAN AGRICULTURAL UNIV +2

Florfenicol suspension injection and preparation procedure thereof

The invention discloses a florfenicol suspension injection and a preparation procedure thereof, and relates to a medicine and a preparation procedure. The drug substance of the florfenicol suspension injection provided by the invention comprises the following components in part by weight: 40-100 parts of fat soluble florfenicol, 1.5-5 parts of suspending agent, 2-4 parts of wetting agent, 0.8-1.2 parts of citric acid, 0.3-0.5 parts of sodium citrate, 0.5-1 part of butylated hydroxytoluene and 5-40 parts of benzyl alcohol. The preparation procedure comprises the following steps: water for injection is used to dissolve the prescribed suspending agent into rubber paste to get solution 1; fat soluble florfenicol is evenly mixed with a wetting agent and water is added into the mixture of the fat soluble florfenicol and the wetting agent to form suspension to get solution 2; solution 1 is slowly added to solution 2 while stirring; citric acid, sodium citrate, butylated hydroxytoluene and benzyl alcohol is added, and then water is added to get 1000 ml of suspension; and the suspension is split and packed after stirring for 30-40 minutes to get florfenicol suspension injection. The florfenicol suspension injection has the advantages of broad antibacterial effect, strong antibacterial activity, low dosing frequency, little stress response and low price.
Owner:HARBIN WILLHOPE ANIMAL HEALTH CARE PROD CO LTD

A formula of an antimicrobial oil emulsion microcapsule for veterinary use

The invention discloses a formula of an antimicrobial oil emulsion microcapsule for veterinary use, wherein per 1000g of the antimicrobial oil emulsion microcapsule contains 50-100g of an antimicrobial agent, 250-500ml of oil for injection, 250-500ml of water for injection, 1-5g of PEG, 5-10ml of sorbitan fatty acid ester, 5-10ml of polyoxyethylene sorbitan fatty acid ester, 250-500g of soluble starch, and 50-100g of methyl cellulose. According to the present invention, the oil emulsion is developed to be microcapsules which can be used for oral administration, thereby maintaining the long-acting and sustained-release effects of the oil emulsion, while in a large extent preventing disadvantages and side reactions in the production and application of the oil emulsion. The preparation process of the microcapsules is relatively simple, reducing the use of organic solvents and thereby reducing the cost of the product.
Owner:HUNAN AGRICULTURAL UNIV

Duck circovirus and adenovirus bivalent inactivated vaccine and preparation method of yolk antibody thereof

The invention relates to a duck circovirus and adenovirus bivalent inactivated vaccine and a preparation method of a yolk antibody thereof. A duck circovirus antigen is obtained by infecting 1-day-oldhealthy cherry valley ducklings and collecting infected duck livers at the age of 25 days to obtain antigen tissues, and an adenovirus antigen is obtained by infecting SPF chickens of 20 days old to30 days old and collecting livers of dead chickens; an antigen of the vaccine consists of liver tissues infected with the duck circovirus and liver tissues infected with the adenovirus in a mass ratioof (1-5):1, and an antigen solution for the vaccine is prepared; and a pine pollen polysaccharide with a concentration of 5-40mg/mL is added into the antigen solution to serve as an immunopotentiator, and the antigen solution is emulsified with a conventional white oil adjuvant to obtain the vaccine. The yolk antibody is obtained by immunizing laying hens with the vaccine, and then performing extracting and purifying on egg yolks of high-immunity laying hens, and the yolk antibody simultaneously contains two antibodies against the duck circovirus and the adenovirus. The vaccine and yolk antibody provided by the invention have the advantages of simple preparation process, low cost, good action effect, stable dosage form and easy storage, and has a wide application prospect.
Owner:山东百瑞凯来生物科技有限公司

Cefalexin oil suspension and preparation method thereof

InactiveCN106309365AGood penetration and dispersibilityStableAntibacterial agentsOrganic active ingredientsPhysical stabilityAntioxidant
The invention discloses a cefalexin oil suspension. Every 100mL of the suspension contains the following raw and auxiliary materials: 2-30g of cefalexin, 0.9-1.0g of surfactant, 1.0-5.0g of colloid protective agent, 7.5-12.5g of suspending agent, 0-0.1% of antioxidant and the balance of oil phase. Under the condition of adopting specific auxiliary material varieties and proportions, the prepared suspension has the advantages of favorable physical stability, favorable needle penetrability and favorable redispersibility, and does not have the condition of quality reduction after being stored in a 4-60-DEG C environment for 3 months, which indicates stable quality.
Owner:CHENGDU QIANKUN VETERINARY PHARMA

Praziquantel nanoemulsion in situ gel for preventing and treating bilharziasis and preparation method and application thereof

The invention discloses praziquantel nanoemulsion in situ gel for preventing and treating bilharziasis and a preparation method and application thereof. The modern nano preparation technology is applied, firstly, hydrophobic praziquantel is prepared into O / W type nanoemulsion which can be mixed with water in any proportion, secondly, the O / W type nanoemulsion is highly dispersed into hydrophilic reverse gel, and water-based injection which is uniform, transparent, good in stability and nozzle cleaning performance and appropriate in viscosity is prepared. The praziquantel nanoemulsion in situ gel has the advantages that in vivo experiments show that the provided praziquantel nanoemulsion in situ gel has an obvious controlled-release character, the function of preventing and treating bilharziasis can be prolonged, medicinal degradable materials are adopted in the medicine composition, and the problems of irritation and injection site lesions do not exist.
Owner:LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS

Long-acting cefquinome sulfate injection and preparation method thereof

The invention relates to a long-acting cefquinome sulfate injection and a preparation method thereof. The injection solution comprises, by weight, 2 to 3 parts of cefquinome sulfate, 2 to 3 parts of a suspending aid, 0. 5 to 1 part of a stabilizer, 0.2 to 0.4 parts of an antioxidant, 0.2 to 0.4 parts of a polylactic acid-glycolic acid copolymer, 0.3 to 0.7 parts of a crosslinking agent, 1 to 1.5 parts of a pH stabilizer and 80 to 120 parts of a dispersion medium. In preparation, the suspending aid, stabilizer, antioxidant, polylactic acid-glycolic acid copolymer, crosslinking agent and pH stabilizer are added into the dispersion medium, the mixture is cooled, then cefquinome sulfate is added into the cooled mixture and the mixture is ground. Compared with the prior art, the preparation method improves injection stability and dispersibility and prolongs pharmacodynamic metabolism time. The injection can be slowly released after intramuscular injection, realize a stable drug concentration in the blood, realize the effects the same to those of the multiple interval injection processes of the same type of the conventional dosage form only through one injection process, reduce drug use frequency, reduce a drug use cost and a labor cost and prevent stress response and can be easily stored.
Owner:JIANGXI AOXIN BIOTECH CO LTD +1
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