78results about How to "Fast magnetic response" patented technology

The invention belongs to the technical field of functional material and particularly relates to a magnetic mesoporous titanium dioxide core-shell type compound microsphere as well as a preparation method and applications thereof. The core-shell type compound microsphere takes a ferroferric oxide nano particle cluster as the core and takes mesoporous titanium dioxide with high crystallinity as the shell. The preparation method comprises the following steps: firstly, preparing the ferroferric oxide nano particle cluster with stable citric acid, secondly, wrapping the surface of the cluster with an amorphous titanium dioxide shell through a sol-gel method, and finally, obtaining the magnetic mesoporous titanium dioxide core-shell type compound microsphere through hydro-thermal treatment. By being provided with the mesoporous titanium dioxide shell with high crystallinity, the compound microsphere has the characteristics of high selectivity, high enrichment capacity, high sensitivity and high recovery rate to phosphoeptide; and since a magnetic core exists, the microsphere enriched in phosphoeptide can be separated by magnetism quickly and very conveniently. The method provided by the invention has the advantages that the operation is simple, the process is controllable, and the prepared compound microsphere can be used for analyzing and identifying phosphoeptide with ultra low concentration in a biological sample.

The invention belongs to the technical field of advanced nanocomposites, and particularly discloses a magnetic mesoporous silica microsphere material with a yolk structure and a preparing method thereof. The macromolecule sol-gel chemical synthesis method is adopted first, magnetic nanoparticles are coated with a polymer resin macromolecule shell, then a mesoporous silica shell is grown on the surface of the polymer resin shell in a non-contact mode by means of the water-oil two-phase method, a surface active agent and an organic solvent are removed through solvent washing and extraction, and finally the magnetic mesoporous silica composite microsphere material provided with ordered mesopore ducts, a large cavity and the yolk structure is obtained. The obtained composite microsphere has the large adjustable cavity, a high specific surface area, the mesoporous shell with a uniform and vertical interface, stable and high magnetic responsiveness, a quite uniform size and high dispersity and has broad application prospects in nanoreactors, catalysis, drug sustained release, large-volume bioseparation and adsorption. The method is simple, raw materials are easy to obtain, and enlarged production is facilitated.

The invention relates to an antibody-coupled bionic immune magnetic sphere and a preparation method of the antibody-coupled bionic immune magnetic sphere, belonging to the technical field of nanometer materials. According to the bionic immune magnetic sphere, the water-soluble Fe3O4 nanocluster is taken as the core, a cell membrane coats the core, and an antibody with a modification group is bonded outside the cell membrane through covalent coupling. The preparation method of the antibody-coupled bionic immune magnetic sphere comprises the following steps: preparing the Fe3O4 nanocluster, namely, MNC; preparing cell membrane fragments modified by choline azide, namely, M; reacting MCN and M to obtain a bionic magnetic sphere, and reacting the modification group with the antibody to obtain the antibody with the cyclo-ethynylation modification group; and coupling bionic magnetic sphere solution and the antibody with the cyclo-ethynylation modification group, thus obtaining the bionic immune magnetic sphere provided by the invention. The bionic immune magnetic sphere is good in dispersibility, rapid in magnetic response, and high in identifying efficiency when used for capturing tumor cells, no white blood cells exist in the background, and the captured tumor cells are good in activity. For the preparation method, the raw materials are easily available and have universality in the construction of the bionic immune magnetic sphere.

The invention discloses a preparation method of an epoxy functional core-shell structure magnetic polymer microsphere. The core of the core-shell structure magnetic polymer microsphere disclosed by the invention is ferroferric oxide nanometer crystal druse; the shell layer of the core-shell structure magnetic polymer microsphere is cross-linked polymer containing epoxy functional group. The preparation method comprises the following three steps of: (1), preparing the ferroferric oxide nanometer crystal druse with a high value of saturated magnetic by adopting a solvothermal method; (2), modifying the surface of the ferroferric oxide nanometer crystal druse into a dual-bond functional group by adopting a sol-gel method; (3), coating the polymer shell layer with the epoxy functional group on the surface of the ferroferric oxide nanometer crystal druse by adopting a distillation-precipitation polymerization method to obtain the epoxy functional core-shell structure magnetic polymer microsphere. The epoxy functional core-shell structure magnetic polymer microsphere is narrowly distributed in grain size, controllable in magnetic content, high in surface epoxy radial reaction activity, easy to modify the functional groups including ammonia group, hydroxyl, group, the mercapto group and the like on the surface, capable of being applied to the industrial waste water treatment field by efficiently adsorbing a plurality of heavy meals or organic pollutants, and good in application prospect.

The invention relates to a simple preparation method for a Fe3O4@C@TiO2 magnetic separation photocatalyst. The method includes steps: 1) taking beta-FeOOH nanorods, and dispersing into water to form dispersion liquid; 2) adopting resorcinol and formaldehyde for synthesizing FeOOH@RF core-shell nanorods, and dispersing into ethyl alcohol to form dispersion liquid; 3) adding ethyl alcohol, CH3CN and ammonium hydroxide, and well stirring and mixing to form liquid A; taking ethyl alcohol and CH3CN again, well mixing, and adding TBOT to form liquid B; mixing for room-temperature reaction for a certain time to obtain the nanorods; 4) performing high-temperature calcinations to obtain the Fe3O4@C@TiO2 magnetic separation photocatalyst. The method has advantages that the magnetic-response recyclable Fe3O4@C@TiO2 visible-light nanometer photocatalyst is prepared according to the simple and mild method; the method is simple in operation and low in equipment requirement, and the prepared Fe3O4@C@TiO2 core-shell nanorods are high in dispersity and uniform in nanoparticle size.

The invention belongs to the technical field of advanced nano-composite materials and particularly provides an inorganic magnetic three-dimensional ordered macro-porous (3DOM) material and a preparation method thereof. The preparation method comprises the following steps: firstly, dispersing magnetic nano-particles and polymer microspheres in a solution, so that the gaps formed by arranging the polymer microspheres in an ordered manner can be filled with the magnetic nano-particles by the evaporation self-assembly of the solution; then, filling the remaining gaps of the polymer microsphere/magnetic nano-particle composite material with inorganic oxide sol by the nano-casting method, so that the ordered composite structure can be fixed; and finally, calcining in the presence of nitrogen to remove the polymer microspheres, so as to obtain the 3DOM material. The magnetic 3DOM material has the advantages of higher magnetic response and higher stability, and the 3DOM material is provided with ordered macro-pores which are communicated on a three-dimensional basis. Therefore, the invention is widely applicable in the aspects of bio-separation, drug delivery, catalytic loading and the like. The preparation method is simple and the materials are easily available. Therefore, the invention is suitable for large-scale production.

The invention provides PD-L1 antibody immunomagnetic beads and a preparation method thereof. Each PD-L1 antibody immunomagnetic bead comprises a magnetic microsphere part and an antibody part; the immunomagnetic beads respectively have a structural formula of A-NH-N=CH-B, wherein A represents a magnetic microsphere and B represents a PD-L1 antibody, or A represents a PD-L1 antibody and B represents a magnetic microsphere. When being used for capturing tumor cells, the immunomagnetic beads are not only good in specificity and sensitivity, but also rapid in magnetic response, short in enrichment time and high in capture efficiency. Furthermore, the immunomagnetic beads are stable in properties, small in particle size, good in magnetic responsiveness and good in dispersity. The preparation method is simple and has very high practicality.

The invention discloses a preparation method of a core-shell type boryl magnetic microsphere capable of greatly enriching glycoprotein. The preparation method comprises the following steps: taking ferric trichloride hexahydrate and acetate as raw materials, adopting a solvothermal method to prepare nano ferroferric oxide magnetic particles; adopting a sol-gel method to surface a layer of SiO2 on the surfaces of the nano ferroferric oxide magnetic particles; modifying the magnetic microsphere coated with SiO2, and enabling the surface of the magnetic microsphere to obtain an active vinyl functional group; preparing the core-shell type boryl magnetic microsphere with amino rich in surface through polymerization reaction; modifying a great number of borate groups by the amino in the surface and carboxybenzene borate through amidation reaction, thereby obtaining the core-shell type boryl magnetic microsphere. The core-shell type boryl magnetic microsphere prepared by the preparation methodis uniform in particle diameter distribution, is regular in structure, is controllable in magnetic content, has the characteristics of high magnetic response and surface modification, can separate and purify glycoprotein under a physiological condition, is good in separating ability, and is a biological magnetic separating material with application prospect.

The invention provides an E-cadherin, Cadherin-11 and EpCAM multi-antibody immunomagnetic bead and a preparation method thereof. The multi-antibody immunomagnetic bead comprises E-cadherin immunomagnetic beads, Cadherin-11 immunomagnetic beads and EpCAM immunomagnetic beads, wherein the E-cadherin immunomagnetic beads, the Cadherin-11 immunomagnetic beads and the EpCAM immunomagnetic beads are immunomagnetic beads respectively obtained by coupling an E-cadherin antibody, a Cadherin-11 antibody and an EpCAM antibody with magnetic microspheres. The multi-antibody immunomagnetic bead is used for capturing CTC and has the effects that the specificity and the sensibility are good, the magnetic response is rapid, the enrichment time is short, and the capturing efficiency is high; and furthermore, the performance is stable, the particle size is small, and the magnetic responsiveness and the dispersity are good. Furthermore, the preparation method is simple and has very strong practicability.

The invention discloses a method for preparing a magnetic field driven intelligent flexible material. The method comprises the following step: by taking mold molding as a preparation method, N,N-dimethyl acrylamide hydrogel as a substrate material, and Fe3O4 nanoparticles as a magnetic response phase, and nano wood plasma cellulose as a reinforcing phase, carrying out in-situ free radical polymerization, so as to obtain the magnetic field driven intelligent flexible material of different magnetic response speeds. The material prepared by using the method is rapid in magnetic field response speed, high in mechanical strength, long in service life, in addition low in production cost, convenient to process and manufacture and wide in application range.

The invention discloses a method for preparing carbon-copper-coated ferroferric oxide composite magnetic oil removal particles. The method comprises the following steps of modifying ferroferric oxide,introducing a carbon source, adding a lubricant, an emulsifying and thickening agent and a stabilizer, and then carrying out heat treatment so as to prepare the Fe3O4@C/Cu composite magnetic oil removal particles. The method has the advantages that the technical problems that a floating oil cleaning technology is tedious in preparation process, incapable of realizing mass production and the likecan be solved; and the particles prepared through the method is high in surface carbonization degree and stable in carbon layer, mass production can be realized, and the good particle preparation method solves the problem of floating oil on the water surface.

The invention discloses a method for synchronously enriching and purifying aflatoxin B1 and capsaicine. The method comprises the following steps: mixing bacteria spheres loaded with reduced graphene oxide and obtained by culturing aspergillus flavus fungal spores which do not produce toxin with a precursor of iron, and preparing a magnetic composite nano material by taking ascorbic acid as a reducing agent through a hydrothermal method; adding the material into a sample extracting solution, and fully mixing the materials to adsorb aflatoxin B1 and capsaicine; adsorbing the magnetic composite nano material by using a magnet, and removing the sample extracting solution; adding the purification liquid, fully and uniformly mixing the liquid with the magnetic composite nano material, adsorbingthe magnetic composite nano material by using a magnet, and removing the purification liquid; and finally, adding the eluent, fully and uniformly mixing the magnetic composite nano material, adsorbingthe magnetic composite nano material by using a magnet, and concentrating the collected eluent to obtain a concentrated solution containing a target object. The method is simple and convenient to operate, short in consumed time, low in cost and capable of synchronously enriching aflatoxin B1 and capsaicine.

The invention relates to a functional magnetic material for selective separation of pepsase, wherein the functional magnetic material is prepared by the following preparation steps: preparing ferroferric oxide particles, namely preparing silicon dioxide-coated ferroferric oxide particles by using tetraethoxysilane as a silicon source; adding functional monomers containing glycosyl and positive charges into an aqueous solution, freely polymerizing with allyl triethoxysilane in the presence of an initiator, introducing nitrogen into the mixed solution to remove oxygen, and carrying out a reaction at normal temperature; after the polymerization is finished, adding ferroferric oxide coated with silicon dioxide, and carrying out a reaction in a water bath; and washing the obtained material withdistilled water, and drying to obtain the material. The functional magnetic material disclosed by the invention is good in biocompatibility and good in dispersity; the material has the advantages ofuniform particle size, strong adsorption performance on pepsase, stable performance, realization of repeated use, repeated use for at least six times, realization of the separation of pepsase after the material is placed in a room temperature dry environment for half a year, great saving of the use production cost, and wide application prospect.