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Water soluble biocompatible fluorescent magnetic nanoclusters and preparation method thereof

A biocompatible and magnetic nanotechnology, applied in the direction of magnetic materials, magnetic objects, inorganic materials, etc., can solve the problems of poor dispersion and low packaging efficiency of encapsulation methods, and achieve improved dispersibility, adjustable size, biophase good capacitive effect

Active Publication Date: 2016-09-14
BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the packaging efficiency of the encapsulation method is not high, and the surface modification method destroys the hydrophilic groups (such as carboxyl groups) on the surface of the particles, resulting in poor dispersion in the aqueous phase, and the magnetic particles have a strong quenching effect on the surface fluorophores.

Method used

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  • Water soluble biocompatible fluorescent magnetic nanoclusters and preparation method thereof
  • Water soluble biocompatible fluorescent magnetic nanoclusters and preparation method thereof
  • Water soluble biocompatible fluorescent magnetic nanoclusters and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 0.9 grams of iron oleate and 2.4 grams of double-terminal carboxypolyethylene glycol (M n =600Da) was dissolved in 5 grams of phenyl ether, and after the dissolution was complete, the temperature was raised to 100° C. and maintained for 30 minutes, and then heated to reflux for 5 hours. After the reaction solution was cooled to room temperature, 15 milliliters of ether and acetone mixed solvents were added (the volume ratio of ether and acetone was 5 :1) Precipitation of Fe with carboxyl groups on the surface 3 o 4 magnetic nanoclusters and washed 3 times, the obtained water-soluble biocompatible Fe 3 o 4 Magnetic nanoclusters were dissolved in deionized water and dialyzed for 2 days to obtain purified water-soluble biocompatible Fe 3 o 4 Magnetic nanoclusters, water-soluble biocompatible Fe can be obtained after freeze-drying 3 o 4 Magnetic nanocluster dry powder.

[0034] The obtained magnetic nanocluster dry powder was redissolved in deionized water, and the s...

Embodiment 2

[0036] 0.9 grams of iron oleate and 1.8 grams of double-terminal carboxypolyethylene glycol (M n =600Da) was dissolved in 5 grams of phenyl ether, and after the dissolution was complete, the temperature was raised to 100° C. and maintained for 30 minutes, and then heated to reflux for 2 hours. After the reaction solution was cooled to room temperature, 15 milliliters of ether and acetone mixed solvent were added (the volume ratio of ether and acetone was 1 :5) Precipitate Fe with carboxyl groups on the surface 3 o 4 magnetic nanoclusters and washed 3 times, the obtained water-soluble biocompatible Fe 3 o 4 The magnetic nanoclusters were dissolved in deionized water, and filtered three times using a centrifugal filter (the molecular mass cut-off was 1,0000Da) to obtain purified water-soluble biocompatible Fe 3 o 4 Magnetic nanoclusters, water-soluble biocompatible Fe can be obtained after freeze-drying 3 o 4 Magnetic nanocluster dry powder.

[0037] The obtained water-so...

Embodiment 3

[0039] 0.62 grams of manganese oleate and 1.8 grams of double-ended carboxypolyethylene glycol (M n =600Da) was dissolved in 5 grams of phenyl ether, and after the dissolution was complete, the temperature was raised to 100° C. and kept for 30 minutes, and then refluxed for 2 hours. After the reaction solution was cooled to room temperature, 15 milliliters of ether and acetone mixed solvent were added (the volume ratio of ether and acetone was 1: 5) Precipitation of MnO with carboxyl groups on the surface 2 The magnetic nanoclusters were washed three times, and the obtained water-soluble biocompatible magnetic nanoclusters were dissolved in deionized water, and filtered three times using a centrifugal filter (the molecular mass cut-off was 1,0000Da) to obtain purified Water-soluble biocompatible MnO 2 The magnetic nano-cluster can obtain water-soluble biocompatible magnetic nano-cluster dry powder after freeze-drying.

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Abstract

The invention discloses water soluble biocompatible fluorescent magnetic nanoclusters and a preparation method thereof. A metal precursor and biocompatible macromolecules are dissolved in a high-boiling-point non-polar or weakly polar solvent, while magnetic nanoclusters are formed through a high temperature decomposition method, the surface of the nanoclusters are modified with the biocompatible macromolecules in situ, and the water soluble biocompatible magnetic nanoclusters with different sizes are prepared; carboxyl and other functional groups carried on the surface of the nanoclusters are coupled with fluorescent molecules, and thus the fluorescent magnetic bifunctional nanoclusters are obtained. The preparation method has the advantages of simple process, easy operation, and low cost of raw materials; the obtained water soluble biocompatible magnetic nanoclusters have the advantages of adjustable size, strong magnetic response and good biocompatibility, can be used as materials of portable biosensors or related environment biosensors, and also can be used in magnetic resonance imaging, fluorescence imaging, cell screening and other biomedical fields.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation, in particular to a water-soluble biocompatible fluorescent / magnetic nanocluster and a preparation method thereof. Background technique [0002] The physical and chemical properties of magnetic nanomaterials are different from those of conventional materials, and they have shown broad application prospects in biomedicine, such as magnetic resonance imaging, disease diagnosis, and magnetothermal therapy. In particular, highly magnetically responsive magnetic materials can be applied to high-efficiency cell separation, drug delivery, and magnetothermal therapy due to their rapid response to external magnetic fields. However, in order to ensure that the material has superparamagnetism, the particle size is generally less than 30 nanometers. Due to the large specific surface area, its magnetic strength is easily reduced by the influence of the surface state and structure, which severe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/06C09K11/02H01F1/01
CPCC09K11/025C09K11/06C09K2211/1088H01F1/0054
Inventor 录驰冲王浩
Owner BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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