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Polydopamine multi-level nano-drug carrier, and preparation method and application thereof

A polydopamine multi-level, nano-drug carrier technology, applied in the field of nano-materials, can solve the problems of poor stability, poor magnetic response, and low coating degree of nanoparticles, and achieve good photostability, high coating degree, and magnetic response. good performance

Inactive Publication Date: 2020-05-01
SHENZHEN PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the superparamagnetic iron oxide nanoparticles in the prior art have the following disadvantages: the template does not have metal affinity, resulting in low coating degree of nanoparticles and poor magnetic response; poor stability and low photothermal conversion efficiency; most solutions require Additional modification of the surface group of the template is required to attach chemotherapeutic drugs

Method used

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  • Polydopamine multi-level nano-drug carrier, and preparation method and application thereof
  • Polydopamine multi-level nano-drug carrier, and preparation method and application thereof
  • Polydopamine multi-level nano-drug carrier, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0035] (1) Measure 40mL of ethanol, 90mL of ultrapure water and 2.2mL of ammonia water, and pour them into a 250mL reaction bottle. Weigh 0.5 g of dopamine hydrochloride and dissolve it in 10 mL of water, quickly add it into the above mixed solution under vigorous stirring, and magnetically stir at room temperature for 30 h. The solution was centrifuged to collect the precipitate and washed several times with water to obtain PDA microspheres.

[0036] (2) The PDA microspheres prepared above (about 40 mg in dry weight) were dissolved in 1 mL of ethanol and added to a 50 mL two-necked reaction flask. Then add 240mg Fe(acac) 3 and 20 mL of TEG. The temperature of the solution was raised to 70 °C under vacuum and maintained for more than 15 min to remove ethanol. Fill the bottle with nitrogen and raise the temperature to 210°C and magnetically stir for 2h; continue to rise to 285°C and stir for 1h. After the solution was cooled to room temperature, an equal volume of acetone w...

Embodiment 2

[0042] (1) Measure 40mL of ethanol, 90mL of ultrapure water and 2.2mL of ammonia water, and pour them into a 250mL reaction bottle. Weigh 0.5 g of dopamine hydrochloride and dissolve it in 10 mL of water, quickly add it into the above mixed solution under vigorous stirring, and magnetically stir at room temperature for 30 h. The solution was centrifuged to collect the precipitate and washed several times with water to obtain PDA microspheres.

[0043] (2) The above-prepared wet precipitate (about 40 mg in dry weight) was dissolved in 1 mL of ethanol and added to a 50 mL two-necked reaction flask. Then 120 mg Fe(acac)3 and 20 mL TEG were added. The temperature of the solution was raised to 70 °C under vacuum and maintained for more than 15 min to remove ethanol. Fill the bottle with nitrogen and raise the temperature to 210°C and magnetically stir for 2h; continue to rise to 285°C and stir for 1h. After the solution was cooled to room temperature, an equal volume of acetone ...

Embodiment 3

[0048] (1) Measure 40mL of ethanol, 90mL of ultrapure water and 0.7mL of ammonia water, and pour them into a 250mL reaction bottle. Weigh 0.5 g of dopamine hydrochloride and dissolve it in 10 mL of water, quickly add it into the above mixed solution under vigorous stirring, and magnetically stir at room temperature for 30 h. The solution was centrifuged to collect the precipitate and washed several times with water to obtain PDA microspheres.

[0049] (2) The above-prepared wet precipitate (about 40 mg in dry weight) was dissolved in 1 mL of ethanol and added to a 50 mL two-necked reaction flask. Then add 240mg Fe(acac) 3 and 20 mL of TEG. The temperature of the solution was raised to 70 °C under vacuum and maintained for more than 15 min to remove ethanol. Fill the bottle with nitrogen and raise the temperature to 210°C and magnetically stir for 2h; continue to rise to 285°C and stir for 1h. After the solution was cooled to room temperature, an equal volume of acetone was...

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Abstract

The invention provides a polydopamine multi-level nano-drug carrier, and a preparation method and an application thereof. The preparation method comprises the following steps: S1, uniformly mixing ethanol, ultrapure water and ammonia water, then adding a dopamine hydrochloride solution, carrying out stirring at a room temperature for 25-35 h, and centrifugally collecting precipitates so as to obtain PDA microspheres with a particle size of about 120-350 nm; S2, dissolving the PDA microspheres prepared in the step S1 into ethanol, then adding ferric acetylacetonate and polyol, raising the temperature of the solution to 65-75 DEG C under a vacuum condition, keeping the temperature for 15-30 min so as to remove the ethanol, introducing nitrogen, carrying out heating to 200-220 DEG C, carryingout stirring for 2 h, continuing heating to 280-290 DEG C, carrying out stirring for 50-70 min, carrying out cooling to a room temperature, adding isopyknic acetone, carrying out separating with a magnet, and carrying out washing with ethanol so as to obtain PDA@IOs microspheres; and S3, dispersing the PDA@IOs microspheres obtained in the step S3 into a Tris-HCl buffer solution with a pH value of8-9, and carrying out stirring for 22-26 h so as to obtain the polydopamine multi-level nano-drug carrier, namely PDA@IOs@PDA nanometer microspheres. The nanometer microspheres have metal affinity, good magnetic response and high photo-thermal conversion efficiency.

Description

technical field [0001] The invention relates to a polydopamine multi-level nano-medicine carrier, a preparation method and an application thereof, belonging to the technical field of nano-materials. Background technique [0002] At present, superparamagnetic iron oxide nanoparticles (IOs) have excellent biocompatibility and a variety of in vivo diagnosis and treatment modes: including magnetic resonance imaging, targeted enrichment under the action of an external magnetic field, and Tumor hyperthermia has great application potential in molecular imaging diagnosis and targeted therapy of diseases. However, the superparamagnetic iron oxide nanoparticles in the prior art have the following disadvantages: the template does not have metal affinity, resulting in low coating degree of nanoparticles and poor magnetic response; poor stability and low photothermal conversion efficiency; most solutions require Additional surface group modification of the template is required to attach...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/59A61K31/704A61K41/00A61K49/12A61K49/18A61K49/22A61P35/00B82Y5/00B82Y15/00C08G73/06
CPCA61K9/5146A61K9/5192A61K31/704A61K41/0052A61K49/126A61K49/1857A61K49/221A61K49/225A61K47/59A61P35/00B82Y5/00B82Y15/00C08G73/0672A61K2300/00
Inventor 张其清敖丽娇
Owner SHENZHEN PEOPLES HOSPITAL
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