41results about How to "Effective treatment options" patented technology

The invention provides a combined medication combination for tumor immunotherapy. The combined medication combination contains an effective dose of an acyl coenzyme A: cholesterol acyltransferase ACAT1 inhibitor and an effective dose of an immune detection point blocking antibody. The invention further provides a combined medication method for the tumor immunotherapy. By inhibiting the acyl coenzyme A: cholesterol acyltransferase ACAT1, the killing activity of CD8 T cells to tumors can be enhanced, and the acyl coenzyme A: cholesterol acyltransferase ACAT1 and the immune detection point blocking antibody can generate a synergic effect in combined medication, so that the inhibition to the tumors can be further enhanced.

The invention belongs to the field of biology, and relates to early stage detection molecular marker of early stage Angiostrongylus cantonensis disease, and primer and correlated kit thereof. The necessary composition of the diagnostic reagent contains: aca-miR-146a-5p sequence and three related primers (stem loop primer, upstream and downstream primer) designed according to the sequence design. The invention firstly provides an application of aca-miR-146a-5p in preparation for diagnosis of Angiostrongylus cantonensis disease. The diagnostic reagent can accurately and simply detect infection of Angiostrongylus cantonensis at early stage, and can distinguish between meningitis or encephalitis caused by Angiostrongylus cantonensis and other meningitis or encephalitis with good social and economic benefits.

The invention discloses a human body gait monitoring algorithm based on dynamic time planning, and belongs to the field of human body gait recognition methods. An existing gait recognition method is low in recognition precision. The human body gait monitoring algorithm based on dynamic time planning comprises the following steps: acquiring a human body gait video by using a visual sensor, and establishing a human body gait model; acquiring skeleton movement information by adopting a sensor skeleton technology; training a gait monitoring recognition algorithm; performing motion recognition; and performing human gait skeleton diagnosis and evaluation. According to the gait diagnosis and evaluation carried out by the method, the recognition rate can reach 98% at most.

The invention provides a remote-monitoring peristaltic pump transfusion system which mainly consists of a computer host, a wireless routing and switching host, peristaltic pump transfusion instruments, high-definition cameras and the like, wherein each peristaltic pump transfusion instrument consists of main parts such as a peristaltic pump, a lithium battery, a micro computer main circuit board, a transfusion bag, a transfusion bag fixing rack, a weight sensor, a bubble monitoring device, a dripping speed monitoring device, a charging socket, a liquid crystal display screen, a micro speaker, an alarm indicating lamp, a functional key, an LED (Light-Emitting Diode) illuminating lamp, a transfusion (blood transfusion) pipe and a plastic shell. The remote-monitoring peristaltic pump transfusion system has the following beneficial effects: one computer host is connected with the multiple peristaltic pump transfusion instruments by virtue of the wireless routing and switching host and is used for monitoring and controlling, so that manpower source is greatly saved, the transfusion condition of patients can be monitored at any timely, and the use safety is improved; and the remote-monitoring peristaltic pump transfusion system is simple and convenient in fixation, convenient to carry, and particularly suitable for blood transfusion and transfusion on the way of slavaging and transferring patients during wartime, natural disaster and pre-hospital rescue processes.

The invention provides a traditional Chinese medicine preparation treating heart-kidney imbalance type insomnia. The preparation is prepared from phellodendron chinense schneid, hen egg yolk, donkey-hide glue, prepared rehmannia roots, white peony roots, glossy privet fruits, lilies, tuber fleeceflower stems, polygala tenuifolia, spina date seed, cortex albiziae, radix scutellariae, radix gentianae, gardenia jasminoides, lophatherum gracile, platycladi seeds, light wheat, radix asparagi, coix seeds, Chinese yam, fructus lycii, acorus tatarinowii, honey-fried licorice roots and cinnamon. The preparation is remarkable in treatment effect, the effects are better than those of old methods, and an economical, effective and quick treatment scheme is provided for insomnia patients.

The invention relates to a method for assessing mental illness incidence risks for mental health help seekers in China. The method for estimating the mental illness incidence risks comprises the following steps: S1, conducting a brief international neuropsychiatric interview and establishing a baseline; S2, conducting a psychiatric high-risk syndrome structured interview; S3, conducting MCCB neurocognitive assessment; S4, selecting variables for calculation; S5, outputting a prediction result, wherein the variables in S4 include ages, BACS symbolic coding scores, HVLT-R scores, P1 and P2 scores, GAF score changes of one year, and mental illness histories of first degree relatives. The method has the advantages of being high in accuracy, helping doctors to effectively select therapeutic schemes and improving the therapeutic effect of clinical prognosis of patients.

The invention provides a fluorescence detection method for detecting bacterial drug resistance in an individual and a diagnostic kit / diagnostic reagent thereof. According to the fluorescence detection method, absorbance difference under the condition of different wavelengths is detected by using a fluorogenic substrate, which only can be degraded by broad spectrum beta lactamase, through double fluorescence signals and further the bacterial drug resistance of the individual or the biological sample of the individual can be detected. The detection method and the obtained detection kit based on the method can detect the 3rd and 4th generations of drug-resistance bacteria of cephalosporin, which cannot be detected by products available in the markets and can reach a detection value of 10<5>-10<8> drug-resistance bacteria, so that a market blank is filled in, more effective monitoring method and use guide are provided for the use of antibiotics in clinic, and extremely great practical values are achieved.

The invention relates to application of indometacin in preparation of medicines for treating cough. The indometacin is applied to preparation of medicines for treating cough. The indometacin has obvious effects on treating chronic cough and especially refractory cough in chronic cough and provides an effective treatment scheme for difficult and complicated diseases with unknown pathogenesis and complicated pathogenesis.

The invention provides a fluorescence detection method for detecting bacterial drug resistance in an individual and a diagnostic kit / diagnostic reagent thereof. According to the fluorescence detection method, absorbance difference under the condition of different wavelengths is detected by using a fluorogenic substrate, which only can be degraded by broad spectrum beta lactamase, through double fluorescence signals and further the bacterial drug resistance of the individual or the biological sample of the individual can be detected. The detection method and the obtained detection kit based on the method can detect the 3rd and 4th generations of drug-resistance bacteria of cephalosporin, which cannot be detected by products available in the markets and can reach a detection value of 10<5>-10<8> drug-resistance bacteria, so that a market blank is filled in, more effective monitoring method and use guide are provided for the use of antibiotics in clinic, and extremely great practical values are achieved.

The invention provides a drug combination for tumor immunotherapy, which includes an effective amount of an acyl-CoA:cholesterol acyl transferase ACAT1 inhibitor and an effective amount of an immune checkpoint blocking antibody. The present invention further provides a combination drug method for tumor immunotherapy. The present invention finds that inhibiting acyl-CoA:cholesterol acyltransferase ACAT1 can enhance the tumor-killing activity of CD8 T cells, and in combination with immune checkpoint blocking antibodies, the two can have a synergistic effect, and can further enhance the anti-tumor activity. inhibition.

The invention discloses a method and device for measuring morphological parameters of an intracranial aneurysm image. The method includes constructing a three-dimensional model including a parent artery and an aneurysm on the parent artery according to intracranial image data. The three-dimensional model includes The virtual parent artery matched with the parent artery and the virtual aneurysm matched with the aneurysm; the neck plane of the virtual aneurysm is determined based on the three-dimensional model, and the target morphological parameters are determined based on the three-dimensional model and the neck plane. The morphological parameters include at least morphological parameters of the virtual aneurysm. It can be seen that the implementation of the present invention automatically measures the morphological parameters of intracranial aneurysms through the three-dimensional model of intracranial image data and the neck plane of the virtual aneurysm included in the three-dimensional model, which can not only improve the measurement of the morphological parameters of intracranial aneurysms The accuracy of the results can improve the measurement speed of the morphological parameters of intracranial aneurysms, thereby providing scientific reference for medical staff when making treatment decisions.

The invention provides a cloud-based cross-medical conjoined MDT consultation system, belongs to the field of medical treatment, is used for solving the problem that cross-medical conjoined consultation cannot be realized among traditional Chinese medicine conjoined bodies in the prior art, and is beneficial to advantage complementation and reasonable resource utilization of current medical technologies. The consultation system comprises an incidence relation setting module, a cross-medical conjoined consultation application initiating module, a medical record data pushing module, a first auditing module, a consultation data sending module, a consultation module, a consultation diagnosis and treatment scheme sending module, a second auditing module and a final diagnosis and treatment scheme sending module. Based on the consultation system, the problem that cross-medical conjoined consultation cannot be carried out between two medical conjoined bodies is solved.

The invention relates to a chimeric antigen receptor targeting BCMA, which comprises an extracellular domain capable of binding to an antigen, a transmembrane domain and at least one intracellular domain, wherein the extracellular domain is an anti-BCMA single domain antibody; wherein the amino acid sequence of the anti-BCMA single domain antibody is selected from: (a) an amino acid sequence as shown in SEQ ID NO. 1; or (b) a variant which is formed by substitution, addition or deletion of one or more amino acids in the amino acid sequence shown in SEQ ID NO. 1 and which is capable of specifically binding to the chimeric antigen receptor and has a function of binding to BCMA and inducing T cell signaling conduction. The chimeric antigen receptor has smaller clinical side effects and highersafety, can effectively reduce solid tumor focus and effectively improve the treatment effect of tumors.