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Novel use of PK11195

A technology of 1. PK11195, application, applied in the field of medicine, can solve the problem of no inhibition of pigment synthesis and other problems

Inactive Publication Date: 2020-01-21
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, PK11195 has also been reported to have anti-inflammatory effects, but there are no reports of its inhibitory effect on pigment synthesis at home and abroad.

Method used

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  • Novel use of PK11195
  • Novel use of PK11195
  • Novel use of PK11195

Examples

Experimental program
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Effect test

Embodiment Construction

[0030] In order to further clarify the present invention, a series of examples are given below, these examples are completely illustrative, they are only used to specifically describe the present invention, and should not be construed as limiting the present invention.

[0031] Below are part pharmacodynamic tests and results of the present invention:

[0032] Part 1: Effects of PK11195 on Melanin Synthesis in Human Primary Melanocytes

[0033] 1. The effect of PK11195 on the proliferation of human primary melanocytes

[0034] Normal human primary melanocytes in good exponential growth phase were taken, digested, counted, and seeded in 96-well culture plates at a seeding density of 5×10 4 cells / ml, the inoculum volume was 180 μl / well, placed at 37°C, 5% CO 2 Incubate in an incubator for 24 hours; add different concentrations of PK11195 and incubate for 48 hours; add 20 μl MTT to each well, and react in a 37°C incubator for 4 hours; remove the supernatant, add 200 μl DMSO to ...

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Abstract

The invention belongs to the technical field of medicine, relates to novel use of PK11195, and particularly relates to the use of PK11195 or a pharmaceutically acceptable salt thereof in the preparation of a medicine / cosmetic for treating and / or preventing hyperpigmented diseases, especially the use in preparation of a medicine / cosmetic for treating and / or preventing various hereditary, ultraviolet and inflammatory factors-induced hyperpigmentation such as freckles, pregnancy spots, melasma, coffee spots and moles.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a new application of PK11195. Background technique [0002] Skin melanin plays an important role in people's normal social interaction and protection from ultraviolet radiation. Various factors in vivo and in vitro, such as α-melanostimulating hormone (α-MSH), adrenocorticotropic hormone (ACTH), and ultraviolet rays can induce melanin synthesis. However, if a large amount of melanin accumulates in the skin, it will lead to hyperpigmentation diseases, such as freckles, pregnancy spots, chloasma, coffee spots, moles, ultraviolet-induced pigmentation, and hereditary dark skin. Hyperpigmentation diseases not only seriously affect the appearance of patients, but also cause great mental stress to them, and even induce skin cancers, such as melanoma. With the improvement of living standards, people pay more attention to the prevention and treatment of such diseases. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/472A61P17/00A61P17/16
CPCA61K31/472A61P17/00A61P17/16
Inventor 吕金鹏姜松周杨莹安晓虹高榕荫曹妍宋国强恽常军
Owner CHANGZHOU UNIV
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