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Application of indometacin in preparation of medicines for treating cough

A technology for indomethacin and medicine, applied in the application field of indomethacin and medicine, can solve the problems that there is no indomethacin, the treatment medicine for cough can not meet the clinical needs and the like, and achieve the effect of remarkable effect

Inactive Publication Date: 2018-05-18
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT) +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the therapeutic drugs for cough still cannot meet the clinical needs, and there is no report of indomethacin in the treatment of cough, especially the treatment of chronic cough

Method used

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  • Application of indometacin in preparation of medicines for treating cough
  • Application of indometacin in preparation of medicines for treating cough

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specific Embodiment approach

[0020] In order to enable those skilled in the art to better understand and implement the present invention, the present invention will be further described below in conjunction with specific examples.

[0021] The chronic cough described in the present invention is the cough that no abnormality is found on the front and side radiographs of the chest, and the cough time exceeds 8 weeks.

[0022] The refractory cough described in the present invention is a chronic cough whose etiology has not been clarified or treatment has not been relieved after comprehensive examination and treatment, also known as idiopathic cough, unexplained cough, cough hypersensitivity syndrome, including Cough after intractable infection (cough after intractable cold). The comprehensive examination mentioned here refers to at least physical examination, blood routine, chest imaging, lung function, induced sputum cytology and other examinations. Empirical treatment recommended by the Guidelines for Dia...

Embodiment 1

[0024] Chen Moumou, female, 47 years old. Visited in July 2017. The chief complaint was coughing repeatedly for more than 30 years. Due to a cough after catching a cold before 30, mainly dry cough, the cough has no obvious time regularity, dust, oily smoke, cold air, and talking for too long can also induce and aggravate the cough. No abnormality was found in the detection.

[0025] Once treated with "inhalation hormone, cough medicine, omeprazole, mosapride, and traditional Chinese medicine", the cough improved slightly and was easy to recur.

[0026] A diagnosis of intractable cough was made.

[0027] Give indomethacin sustained-release capsule treatment, take 150mg every day, 3 days, the patient complains that cough is obviously better. After 10 days of drug withdrawal, he was followed up and complained of occasional coughing 3-4 times a day. Follow up again after 1 month, tell basically do not cough, a day even cough 1-2 times.

Embodiment 2

[0029] Zhong, female, 27 years old. Visited in September 2017. The chief complaint was coughing repeatedly for more than 8 months. The patient had a dry cough due to a cold before August. The cough was severe during the day and before going to bed. Oil fumes, dust, cigarettes, etc. induced and aggravated the cough. When the cough was severe, shortness of breath and tracheal constriction could occur. Chest imaging, allergen skin test, induced sputum cytology, and lung function showed no abnormalities.

[0030] A diagnosis of cough hypersensitivity syndrome was made.

[0031] He was treated with "antibiotics, oral corticosteroids, inhaled corticosteroids, cough medicine, antiallergic drugs, gabapentin, traditional Chinese medicine", but the cough did not improve.

[0032] Treated with Indomethacin Sustained-release Capsules, taking 75mg per day for 5 days, the patient complained that his cough had improved significantly, and he occasionally coughed 4-5 times a day. Symptoms s...

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Abstract

The invention relates to application of indometacin in preparation of medicines for treating cough. The indometacin is applied to preparation of medicines for treating cough. The indometacin has obvious effects on treating chronic cough and especially refractory cough in chronic cough and provides an effective treatment scheme for difficult and complicated diseases with unknown pathogenesis and complicated pathogenesis.

Description

technical field [0001] The invention relates to the technical field of chemistry and medicine, in particular to the application of indomethacin in the preparation of medicine for treating cough. Background technique [0002] Cough is the most common symptom of respiratory diseases. Chronic cough patients account for more than one-third of respiratory specialist outpatient clinics in China. At present, in the clinical practice of chronic cough treatment, in addition to common cough variant asthma, upper airway cough syndrome, eosinophilic bronchitis, gastroesophageal reflux cough, etc., treatment according to the etiology can achieve good curative effect. For those rare causes, especially refractory chronic cough, repeated inspections are required, and antibiotics, hormones, and various antitussives are given blindly for a long time, which costs a lot but has little effect, which is harmful to the patient's physiology, psychology, and economy. caused a huge burden. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/405A61P11/14
CPCA61K31/405
Inventor 赖克方詹文志
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)
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