The invention relates to a welding method of a tantalum target material assembly. The welding method comprises the following steps: carrying out sand blasting treatment on a welding surface of a tantalum target material, and then carrying out tin film plating treatment on the welding surface of the tantalum target material; carrying out copper film plating treatment on a welding surface of a back plate, then carrying out heating treatment on the tantalum target material plated with the tin film and the back plate plated with the copper film, then arranging mixed metal powder on the welding surface of the tantalum target material and the welding surface of the back plate correspondingly, and then carrying out infiltration treatment; and arranging copper wires on the back plate subjected to infiltration treatment, then assembling the welding surface of the back plate provided with the copper wires and the welding surface of the tantalum target material, and carrying out pressurizing and cooling, so that the tantalum target material assembly is obtained. Welding is carried out by adopting a film plating process and combining with specific mixed metal powder, then the welding bonding strength of the tantalum target material assembly is improved, meanwhile, the service life of the welded target material is prolonged by 20-30%, and when the welded target material assembly is sputtered, the thickness of a plated film obtained in the sputtering process is uniform.